Your guide to laboratory and pathology equipment in Europe € 15.– Automation & Sample Processing Chemistry & Immunochemistry Hematology Pathology DNA Microbiology POCT IT Non-Diagnostic 2018 Vol. 5 Atellica Solution* is a lexible, scalable automation-ready immunoassay and chemistry analyzers engineered to deliver control and simplicity so you can drive better outcomes. Experience the power of the Atellica Solution, featuring patented bidirectional magnetic sample transport technology, the lexibility to create over 300 customizable conigurations, and a broad assay menu with proven detection technologies. *Product availability will vary by country.

Editorial LABBOOK 2018 1 Dear reader, we are pleased to present the 5th edition of our European product guide “Labbook”. Once again we compiled a broad as well as detailed overview of devices, software and accessories for the medical lab. The Labbook has grown in terms of size and of content – a clear indicator that in hospital and non-hospital labs alike the demand for targeted information is huge despite the fact that the market is highly fragmented and political support is sketchy at best. The products in this year’s Labbook cover all aspects of laboratory diagnostics: from clinical chem- istry systems to innovative solutions for pathology, from handhelds for bedside diagnostics to fully automated and multi-disciplinary lab suites. In short: a comprehensive showcase of the industry. However, we want to be more than a mere shopping guide: we want to offer our readers added value. Professor Norbert Gässler looks at the recommendations regarding venous blood sampling by the European Federation of Clinical Chemistry and the Latin America Confederation of Clinical Biochemistry. Since finally the important role of pre-analytics in lab medicine is widely acknow- ledged, international recommendations, including evidence and quality assessments, were issued. Our feature on the selection process for a lab information system (LIS) is another practical guide, aimed to support buyers. The authors provide a handy table with selection criteria that serve as starting point as well as guidance throughout the purchasing process. Finally, and we don’t tire of pointing this out: the Labbook is not only hard copy. For our digital database with products, feature articles and the e-paper version of the Labbooks past and present please visit www.labbook.eu and www.healthcare-in-europe.com. There you will also find the forms to request further information. The manufacturers, the authors and the editorial team – we all look forward to receiving your feedback, be it praise, criticism or suggestions. We would like to know what you want to find in the next edition. Enjoy reading and browsing. Daniela Zimmermann Dr Markus Neumann

Automation & Sample Processing Sample Processing Robotics Automation A u t o m a t e d S a m p l e P r o c e s s i n g

Hecht – Programmable Rotating Mixer Sarstedt – Decapper DC 1200 / Recapper RC 1200 Sample Processing Dimensions: Weight: 93 × 501 × 301 mm (h × w × d) 6 kg Highlights: · The speed can be adjusted in steps of 1 rpm from 10 to 80 rpm. · The rotating mixer TR6 is suitable to mix blood samples, viscous substances and liquid-solid suspensions. · The tilt angle of the rolls is 3°. · Every roll is tool free detachable individually to hold vessels of different sizes. · Mode of operation is noiseless and continuous or with adjustable time from 1 to 99 minutes. · The microprocessor allows to program up to 9 protocols and the use of a pulse mode. Highlights: Decapper DC 1200: · Automatic decapping of all tube diameters from 11 to 16 mm · Processes a variety of tube types in mixed operation · Sample pre-sorting for the decapping process is unnecessary Recapper RC 1200: · Automatic recapping of all tube diameters from 13 to 16 mm · Minimises the risk of exposure · Eliminates sample contamination · Archiving cap fits all tubes from 13 to 16 mm diameter · Automated decapping enabled Efficient lab solutions: More than sorting 2,000 tubes/h ASP SortPro · Individual Workflow analysis · Customized configuration · Seamless LIS connection · Optical tube type detection · Identification of doublets · Process management software A u t o m a t e d S a m p l e P r o c e s s i n g ASP Lab Automation AG Rugenranzel 4 25373 Ellerhoop Germany + 49 4120 7 06 79 - 27 www.asplabauto.com

Sample Processing Efficient lab solutions A machine for automated registration and sorting of blood Once installed, the ASP SortPro will ensure that each specimen will be identified, registered in the LIS, and sorted by internal sorting criteria or input from the LIS. ASP SortPro selects and separates tubes for manual handling. Doublets are detected and can be handled individually. Depending on the individual applica- tion SortPro can handle up to 2,000 tubes per hour. With the new graphical user interface, the software makes it easy to use the device. Administering and editing sorting rules allows the adaptation of the SortPro to changing requirements at any time. With provided extensive documentation and statistical tools, workflow and performance of the sorter can be controlled in detail. The SortPro operates basically unattended. In case user attention is required, the integrated process management sends SMS to operational staff. Tools for maintenance and service guarantee maximum availability while minimizing operating costs. ASP SortPro does not only register and sort your specimens, but with comprehensive integration into your lab workflow, it constantly improves the efficiency of your lab. Starting in Autumn 2018, the improved new generation of ASP SortPro will be rolled out to customers worldwide. LABBOOK 2018 7 specimens is what will be added to your lab after ASP Lab Automation AG has finished the installation. But, you have purchased much more. To make an investment in sorting devices efficient, the device must be integrated perfectly into the labora- tory workflow. The ASP team has sold hundreds of tube sorters to clinical labs and hospitals worldwide. With all these installations, the German Engineers have accumulated deep knowledge about the workflow in clinical labs. This experience is an integral part of every new installation. The sales managers analyze the existing situation and find solu- tions to reach the labs targets for its investment. Optimization of the workflow using the advantages of the new automation device and its integration with the LIS are as important as the individual configuration of the new sorting device. This ability to integrate everything into the perfect solution is what makes ASP so special in providing efficient lab solutions. Therefore, the latest generation of the ASP SortPro instrument is designed to face any kind of requirements by implementing strong software tools and a wide range of options for customization. SortPro can bulk sort a large variety of tubes, can fill specific analyzer racks, or can deliver tubes directly to track systems or analyzers. The SortPro can detect barcodes, cap colors, and tube types. CONTACT ASP Lab Automation AG Rugenranzel 4 · 25373 Ellerhoop, Germany phone: +49 4120 70679-27 info@asplabauto.com · www.asplabauto.com

Automation BioMajesty JCA-BM6010/C connected to Thermo Fisher Sample Conveyor Process optimization in IVD laboratories with DiaSys Laboratory Automation Solution T he DiaSys Total Laboratory Automation system (TLA) is an open, flexible and tailor-made solution for pre-analytical, analytical and post-analytical work. The pre-analytical part may consist of a tube loading module, centrifuge(s) and de-capper. Based on a high number of instrument interfaces and robotic modules users in laboratories can configure the tracking line according to their individual needs and expectations. Besides DiaSys’ BioMajesty JCA-BM6010/C a large selection of immunoassay-, coagulation- and hemato- logy-analyzers can be connected via bypasses for analytics. For post-analytical purposes a re-capper, a cold storage (up to 13.000 tubes) or tube unloading module (incl. retrieval option for re-testing) are available. CONTACT DiaSys Diagnostic Systems GmbH Alte Straße 9 · 65558 Holzheim, Germany phone: + 49 64 32 91 46-0 systems@diasys.de · www.diasys-diagnostics.com A true flexibility and expendability concept The test ordering, sample routing and result management is controlled by a instrument manager software which is connected to the laboratory information system (LIS). Your benefits from Open Lab Automation This concept leads to optimization of processes in the daily routine of IVD laboratories, consolidation of workplaces, reduction of manual work and errors as well as improved turn around time. LABBOOK 2018 9

Experience the power of the Atellica Solution Automation Atellica® Solution:* Flexible, scalable, automation-ready immunoassay and chemistry analyzers engineered to deliver control and simplicity so you can drive better outcomes. A bi-directional magnetic sample transport that is 10 times faster than conventional sample conveyors The new standard in sample management—revolutionary technology that gives independent control over every sample An immunoassay analyzer that runs up to 440 tests per hour,† the industry’s highest productivity per square meter‡ Unprecedented flexibility with more than 300 customizable configurations including L and U shapes *Product availability will vary by country. †Dependent on test mix. ‡Versus leading IVD companies. Atellica is a trademark of Siemens Healthcare Diagnostics Inc. A91DX-9564-A2-4A00. © Siemens Healthcare Diagnostics Inc., 2018 siemens-healthineers.com/atellicasolution LABBOOK 2018 11

laboratorians can deliver results confidently and potentially reduce the time to diagnosis leading to faster treatment. Sepsis is another diagnosis that calls for both speed and accuracy. Sepsis can lead to tissue damage, organ failure, amputations, and death if not diagnosed and treated promptly. Early diagnosis and treatment of sepsis is associated with better patient outcomes. The analytical time-to-result for the Atellica IM BRAHMS PCT Assay, when compared to the predicate system, decreased by 53 percent, with an analytical time of 18 minutes. Overcoming stakeholder concerns to obtain buy-in can equate to better patient outcomes Detecting the presence of disease states sooner arms clinicians with the data they need to properly triage patients faster. However, implementing a change in menu or instru- ments can be met with hesitation from stakeholders, rather than enthusiasm, especially if the change is significant or requires an adjustment to existing protocols or baselines. Educating physicians, pathologists and other stakeholders on the values that new assays deliver is one challenge labs must overcome when considering introducing new assays to the testing menu. The good news is the majority of stakeholders agree that keeping pace with technological advancements is critical to driving better patient outcomes. When asked about the impact of the laboratory on the patient experience, physicians and internists widely agree that investment in laboratory technologies is important. More than three-quarters of doctors and lab directors agreed that labs play a vital role in healthcare systems, and that they are a critical component for patient diagnosis and treatment. Further, more than half of the surveyed physicians and internists noted that investments in lab technology could be very impactful on potentially improving diagnoses. About half of physicians and inter- nists thought it could also be very impactful on improving patient safety and patient outcomes. Engaging stakeholders early in the discussion can help identify points of confusion or objection. Armed with relevant supporting evidence, laboratories can demonstrate how new lab technology and assays can impact clinicians’ capabilities and decisions, and expand precision medicine to deliver a better patient experience. Focusing on outcomes that matter to stakeholders and decision-makers during these discussions, such as patient and phy- sician satisfaction and improved care, showcases direct benefits of technology and assay investments. Emerging evidence also indicates that improved laboratory diagnostics can indirectly benefit hospitals by enhancing reputation and revenue: Test results help clinicians determine whether a patient is critical and needs to stay for further Automation observation or whether a patient is healthy enough to return home. With the right assays, freeing beds sooner for other patients could positively impact patient experience, efficiencies in the healthcare system, and institutional revenue. We can take for example, a cardiac emergency. Overall, cardiovas- cular disease is estimated to cost the EU economy €210 billion a year. Emergency departments that remain crowded with people who aren’t having a cardiac emergency may slow down the diagnosis and treatment of those who really need care. The prevalence rate of non-cardiac chest pain is estimated to be more than 50 percent of all chest pain cases presenting at the emergency department. The majority of the patients seeking care due to chest pain are admitted for in-hospital cardiac “rule out” observation, yet just one-third of the cases are found to be ischemic heart disease.8 In this instance, expanding precision medicine with assays such as TnIH for acute myocardial infarction brings measurable benefits for hospitals. The ability to diagnose specific diseases earlier and accurately helps improve the standard of care for patients experiencing heart attacks and chest pain symptoms. In sum, the instruments and assays found in the laboratory can improve outcomes that matter to many stakeholders. It is often the responsibility of the lab to lobby for upgrades, but all stakeholders should be engaged and educated on the benefits of such advancements. When factors such as the potential revenue impact, demonstrable productivity enhancements, reduction in operational cost, or concerns about impact to existing protocols are addressed early in the process everyone in the health system wins — perhaps, most importantly, the patients. Laboratories might wish to consider the ways the Atellica Solution and its assays can help provide measurable results and align with their most important performance indicators. LABBOOK 2018 13

Chemistry & Immunochemistry Clinical Chemistry Immunochemistry Immunoassays Integrated Systems Mass Spectrometry Electrophoresis/ Chromatography Plasma Protein Testing Drug Testing Urine Screening Rapid Testing Research Use Only

DID YOU KNOW 70 patients worldwide every second have diagnostic samples collected with BD Vacutainer specimen collection products. BD life sciences – Preanalytical systems See the total value F or almost 70 years, BD has advanced the science of specimen BD is one of the largest global medical technology companies ABOUT BD collection that has helped enable laboratory tests to become the foundation for 70 percent of all medical decisions.* Today, the BD Vacutainer product family is a gold standard in sample collection. That is why leading hospitals rely upon it to enhance sample quality and provide a safe environment for nurses, phlebotomists and other caregivers, avoiding needlestick injuries. These products — backed by unrivaled customer support and training — help hospitals and laboratories every day to enhance patient safety and drive lab productivity and workflow by reducing retests, recollects and instrument downtime. * The Lewin Group (2005). The Value of Diagnostics: Innovation, Adoption, and Diffusion into Healthcare. Published for the Advanced Medical Technology Association. Falls Church, VA: Lewin Group; 2005:1. CONTACT BD Business Park Terre-Bonne, Bât A4 Route de Crassier 17 · 1262 Eysins, Switzerland phone: +41 21 556 30 00 · pas_info@bd.com · bd.com in the world and is advancing the world of health by improving medical discovery, diagnostics and the delivery of care. The company supports the heroes on the frontlines of health care by developing innovative technology, services and solutions that help advance both clinical therapy for patients and clinical process for health care providers. BD and its 65,000 employees have a passion and commitment to help improve patient outcomes, improve the safety and efficiency of clinicians’ care delivery process, enable laboratory scientists to better diagnose disease and advance researchers’ capabilities to develop the next generation of diagnostics and therapeutics. BD has a presence in virtually every country and partners with organizations around the world to address some of the most challenging global health issues. By working in close collabora- tion with customers, BD can help enhance outcomes, lower costs, increase efficiencies, improve safety and expand access to health care. In 2017, BD welcomed C. R. Bard and its products into the BD family. For more information on BD, please visit bd.com.

Chemistry & Immunochemistry DiaSys Diagnostic Systems – BioMajesty JCA-BM6010/C DiaSys Diagnostic Systems – respons910 No of channels: Assays: Sample throughput: Dimensions: Weight: 45 55 1,200 samples / h 1,220 × 1,108 × 850 mm (h × w × d) 450 kg Highlights: BioMajesty JCA-BM6010 / C is designed to increase the performance of medium-sized laboratories. Throughput of up to 1.200 tests / hour, up to 45 reagent and 84 sample positions guarantee flexibility in everyday use. It handles a full menu of clinical chemistry assays as well as Na, K, Cl determination by indirect ISE. The possibility to connect the device to a sample conveyor system offers a complete automation solution and the consolidation of clinical chemistry with immunology and coagulation testing. No of channels: Assays: Sample throughput: Dimensions: Weight: 30 63 up to 150 samples / h 600 × 600 × 670 mm (h × w × d) 60 kg Highlights: respons910 is a fully-automated bench top analyzer for maximum efficiency. High on-board capacity of 30 methods and 30 sample positions combined with a throughput of 150 tests / h offers the flexibility for everyday use. A STAT port allows loading of emergency samples at any time. High-quality clinical chemistry and immunoturbidimetric tests from DiaSys round off the respons910 system. Diatron – Intelligent Walk Away Chemistry with P500 FUJIFILM – DRI-CHEM NX700 Sample throughput: Dimensions: 190 samples / h 500 × 380 × 410 mm (w × d × h) Sample throughput: Dimensions: Weight 300 tests / h, 480 with ISE 900 × 660 × 620 mm (h × w × d) 115 kg Highlights: Highlights: · Bench top, fully automated Clinical Chemistry system · Advanced Windows-based software · Uninterrupted workflow, enhanced walk-away operation and remote access diagnostics · Dri-Chem based Clinical Chemistry Analyser · 31 Test Parameter – unit-use · Intuitive and simple operation · No calibration needed by use of QC-card · Immediate start up time – no preparation delay · Maximum of five specimen in one operation · Real walk-away system – consumables loaded · Accurate and reliable results from field-proven · Full range of barcoded reagents, controls and calibrators dri-chem technology LABBOOK 2018 19

Chemistry & Immunochemistry Mindray – BS-240Pro Clinical Chemistry Analyzer Mindray – BS-480 Clinical Chemistry Analyzer Sample throughput: Dimensions: Weight: Constant 240 t / h, up to 400 t / h with ISE 860 × 550 × 660 mm (w × h × d) 115 kg Highlights: · Constant throughput with 240 photometric t / h, up to 400 t / h with ISE module · Large and flexible capacity: up to 100 sample / reagent positions (50 fixed + 50 interchangeable) · Reduced reagent consumption: 100 μL minimum reaction volume · Intelligent probe with liquid level detection, V&H collision detection, inventory monitoring, reagent pre-heating and optional clog detection · Grating photometer with 12 wavelengths, dual-diaphragm and dual-lens · HbA1c smart-sampling function, automatic hemolysis Sample throughput: No of parallel samples: Dimensions: Weight: Constant 400 t / h, up to 560 t / h with ISE Up to 78 on-board chemistry tests 1,185 × 1150 × 710 mm (w × h × d) 300 kg Highlights: · Discrete, random access, fully automated · Constant throughput with 400 photometric t / h, up to 560 t / h with ISE · 24-hour on board refrigerated reagent compartment at 2~10 C · Reusable cuvettes with auto-washing station · Two independent mixing stirrers · Clot detection, automatic probe cleaning, liquid level detection & collision protection (V&H) · Reversed grating system with 12 wavelengths (340~800nm) · Pre-dilution and post-dilution for sample · Built-in barcode scanner · Bi-directional LIS interface Mindray – BS-800M Clinical Chemistry Analyzer Sentinel – SENTiFIT270 (Sysmex) Sample throughput: No of parallel samples: Dimensions: Weight: Constant 800 t/h, up to 1,200 t/h with ISE Up to 68 on-board chemistry tests 1,600 × 1,200 × 1,015 mm (w × h × d) ≤ 450 kg for analytical unit, 150 kg for SDM Highlights: · Modular system: flexible connection · HbA1c smart sampling, automatic hemolysis · Accurate: high pipetting precision, coolant circulation reagent refrigeration direct solid-heating system, effective mixing unit and intelligent clot detection · Innovative: reagent bubble detection, dot light source and water quality monitor · Cost-efficient: large capacity with SDM racking system, 100 μl minimum reaction volume, one key STAT, continuous reagent loading and unloading · Original calibrators with traceability Sample throughput: Dimensions: Weight: Assays: Up to 270 samples / h 625 × 870 × 670 mm (h × w × d) 120 kg Fecal Immunochemical Test Calprotectin Test Highlights: The SENTiFIT270 is a fully automated clinical-chemical system. It has been specially developed to measure the SENTiFIT pierceTube for quantitative determination of occult faecal haemoglobin. · Continuous reloading of the racks during measurement · Cooling the reagents for permanent storage in SENTiFIT 270 · Measure up to 1,250 tests without changing the reagent · Automatic warning of deviation of the fluid level · Integrated sensor prevents blocking of the sample needle · Barcode reader for reagents LABBOOK 2018 21

Chemistry & Immunochemistry DRG Instruments – DRG:HYBRiD-XL Fujirebio – LUMIPULSE G1200 Sample throughput: No of parallel samples: Assays: Dimensions: Weight: 40 tests per run 40 Immunoassay and Clinical Chemistry 586 × 608 × 635 mm (h × w × d) 52 kg Highlights: This unique technology allows the simultaneous measurement of immunoassays and clinical chemistry parameters in one sample: TSH receptor Ab, Anti-tTG (Transglutami nase), Anti-DGP (Gliadin), Calprotectin, 17-OH Prog., Free Testosterone, Renin, Aldosterone, 25-OH Vitamin D, Hepcidin-25 and more Sample throughput: Time to first result: Sample capacity: Reagent capacity: Dimensions: 120 tests / h 30 min Up to 100 samples 504 tests on board 1,450 × 1,200 × 800 mm (h × w × d) Highlights: A compact, robust and reliable fully automated chemiluminescent enzyme immunoassay analyzer. The LUMIPULSE G1200 offers optimized reagent and consumables handling, true random access, and a con- stant throughput regardless of the assay format or combination. The unique mono test cartridge elimi- nates open reagent bottle stability concerns. It comes with the broad menu of routine and unique Lumipulse G biomarkers and is fully compatible with laboratory automation systems (LIS). Fujirebio – LUMIPULSE G600II Sarstedt – ELISA Plates / Micro test plates for immunoanalytics Sample throughput: Time to first result: Sample capacity: Reagent capacity: Dimensions: 60 tests / h 35 min Up to 36 samples (incl. 3 priority specimens) 112 tests on board 642 × 890 × 725 mm (h × w × d) Highlights: A fully automated benchtop chemiluminescent enzyme immunoassay analyzer. The LUMIPULSE G600II offers optimized reagent and consumables handling, true random access, and a constant throughput regardless of the assay format or combination. The unique mono test cartridge eliminates open reagent bottle stability concerns. It comes with the broad menu of routine and unique Lumipulse G biomarkers. Highlights: One of the analyses most commonly used is the Enzyme-Linked Immunosorbent Assay (ELISA). With this method, even the smallest concentrations of a range of substances (proteins, peptides, antibodies, hormones etc.) can be detected and quantified from complex solutions. LABBOOK 2018 23

Chemistry & Immunochemistry Beckman Coulter – Access Active B12 FUJIFILM Wako – µTASWako i30 Highlights: The Access Active B12 is Beckman Coulter’s newest addition to an already comprehensive menu for anaemia disease-state management. With the largest measuring range on the market, fastest time to first result and standardization to WHO International Standard (IS) 03/178, the Access Active B12 delivers a better solution over other methods for Total B12 testing. While traditional serum B12, testing measures the entirety of circulating B12 only the Active B12 assay measures the biologically active form. A growing body of evidence suggests that when used as screening or resolving test, Active B12 provides a more reliable and earlier indicator of B12 deficiency. Dimensions: Weight: Sample throughput: Assays: 520 × 550 × 600 mm (w × h × d) 71 kg 25 tests / h AFP / AFP-L3, DCP Highlights: · Electrokinetic Analyte Transport Assay (EATA) · High sensitive fluorescence detection · Assay precision less than 3% CV for AFP-L3 · Increased sensitivity of liver cancer (HCC) detection by combined use of AFP, AFP-L3 and DCP · Unique system to calculate the GALAD score (Gender, Age, AFP-L3, AFP, DCP) for outstanding p erformance regarding early HCC recognition · Improved chance of detecting HCC early during surveillance of patients at risk Genrui – Automatic Specific Protein Analyzer Lifotronic – eCLA8000 Electro ECLIA System Sample throughput: Assays: Dimensions: Weight: 60 tests / h 22 620 × 520 × 620 mm (w × d × h) 60 kg Highlights: · Fully-automatic specific protein analyzer · Latex Nephelometry · 60 samples per hour · 1-click, multi-results · Efficient and less cost · User-friendly software and UI design · Whole blood samples accepted · NGSP certified for HbA1c testing · Your right hand in daily laboratory work Highlights: Chemiluminescence immunoassay (ECLIA) System · Throughput: 85 t / h · 10 reagent channels · 30 sample positions · 100 reaction positions · 10 mins for first sample result · Auto calibration and QC (2 level) · Reagent & sample liquid level detection with clotting test · T3, T4, TSH, PCT, HCG, NT-proBNP, more items are coming LABBOOK 2018 25

Chemistry & Immunochemistry Mindray – CL-1000i Chemiluminescence Immunoassay System Mindray – CL-900i Chemiluminescence Immunoassay System Sample throughput: No of channels: Assays: Dimensions: Weight: Up to 120 tests / h 25 63 1,300 × 760 × 600 mm (w × h × d) 225 kg Highlights: · High throughput up to 120 tests per hour · Benchtop analyzer · Large reagent capacity with 25 positions · Sample rack system · STAT lane · Single cuvette system · Dual substrate and automatically switch the empty one Sample throughput: No of channels: Assays: Dimensions: Weight: Up to 180 tests / h 15 63 860 × 740 × 560 mm (w × h × d) 130 kg Highlights: · High throughput up to 180 tests per hour · One of the smallest benchtop CLIA analyzer · Reagent capacity with 15 positions · Single cuvette system · Dual substrate and automatically switch the empty one · Intuitive software interface, easy access to all functions · Continuously loading of lntelligent consumables manage- ment reagents and consumables Next Level of Laboratory Automation DiaSys Diagnostic Systems and Tosoh Bioscience present consolidation of clinical chemistry and immunoassay analysis; either simply with a middle- ware or fully automated with a track system. Tailor made solutions for individual customer needs! www.diasys-diagnostics.com

Chemistry & Immunochemistry Snibe – MAGLUMI 800 INTEGRATED SYSTEM Beckman Coulter – Power Link Workcell Sample throughput: Dimensions: 180 tests / h 1,020 × 720 × 560 mm (h × w × d) Highlights: · On board capability: up to 40 samples · Reagent position: 9 · Refrigerated sample and reagent area · Clot detection · Liquid level detection · Auto dilution for high concentration sample · Color touch screen · Bi-communication with LIS via ASTM protocol Highlights: · Parallel processing of shared chemistry and 0immunoassay specimens · Single point of loading and unloading for shared chemistry and immunoassay samples for rapid processing · Integrated decapper to minimize biohazard exposure risk and repetitive motion injuries The Power Link offers laboratories the ability to combine a DxC700AU chemistry analyzer with a DxI immunoassay analyzer to form an entry-level automated workcell, streamlining laboratory workflow. The Power Link delivers high-capacity specimen processing power and flexibility to meet clinical laboratory workload challenges. Designed to help enhance efficiency, reduce costs and speed the delivery of test results Mindray – SAL 9000 Modular System Mindray – SAL 6000 Modular System Highlights: · Consist of clinical chemistry analyzer BS-2000M and chemiluminescence immunoassay analyzer CL-6000i · Large capacity: new rack system with up to Sample throughput: No of channels: Assays: Dimensions: Weight: Chemistry 1,200 tests / h, Immunology up to 240 tests / h 36 63 3,935 × 1,016 × 1,145 mm (w × h × d) 1,078 kg 30 racks (300 samples), continuous loading supported Highlights: · Easy operation: Intuitive interface for ONE integrat- ed system operation software, real-time indication of cuvettes, real-time QC status monitoring, waste and wash buffer status, reflex and re-run function, step-by-step maintenance guide, etc · New SDM achieves effective distribution, quick response, fast STAT The SAL 6000 Modular System is a high-performance integrated system connecting seamlessly the BS-800M Chemistry Analyzer with the CL-2000i Chemiluminescence Immunoassay Analyzer, with a throughput of up to 800 photo metric tests per hour and 240 tests per hour respectively. The system offers a large capacity of 300 sample positions and 36 reagent positions, and supports non-stop continuous sample loading. LABBOOK 2018 29

Chemistry & Immunochemistry Shimadzu – LCMS-8060 CL Shimadzu – LCMS-8045 CL Dimensions: Weight: Highlights: 1,180 × 540 × 610 mm (w × d × h) 140 kg The LCMS-8060 delivers the highest sensitivity and fastest analysis speed of any LCMS on the market today. A newly developed UF-Qarray boosts ion intensity but suppresses noise. By improving the ion sampling device, the ion guide, and vacuum efficiency, Shimadzu has achieved an unprecedented sensitivity in quantitative analysis by LC / MS / MS while keeping high robustness for daily analysis. Dimensions: Weight: Highlights: 1,180 × 540 × 610 mm (w × d × h) 140 kg The LCMS-8045 offers the proven high sensitivity, high speed and robustness of Shimadzu’s UFMS series to provide highly reliable data for applications that demand the sensitivity and speed of a mass spectro- meter, such as for simultaneous analysis used in the clinical research field. Due to the heated-ESI probe and UFsweeper II collision cell, it offers the highest sensitivity in the middle-range class (UFsensitivity). Shimadzu – nSMOL Antibody BA Kit biostep – Chemiluminescence / Fluorescence Imager Celvin S ELECTROPHORESIS / CHROMATOGRAPHY Assays: 100 Highlights: nSMOL is a proprietary, innovative technique from Shimadzu, enabling selective proteolysis of the Fab region of monoclonal antibodies. The nSMOL Antibody BA Kit is a ready-to-use reagent kit for collecting monoclonal antibodies from blood or other biological samples using immunoglobulin collection resin, and then performing selective proteolysis of the Fab region of these antibodies via FG beads Trypsin DART. Fab-derived peptide fragments produced by limited digestion can then be quantified via LC-MS / MS. Dimensions: Weight: 420 × 240 × 360 mm (h × w × d) 10 kg Highlights: · Smallest chemiluminescence imaging system, imaging area up to 14 × 14 cm · Cooled CCD-camera · Binning up to 6 × 6 · Four camera options from high resolution to high sensitivity · Electromagnetic safety lock · Acquisition of colorimetrically-stained markers possible · GxP-compliant in Master and Serial Mode · Image export as raw data for analysis or as optimized image for publication · Fluorescence module incl. four excitation and emission wavelength settings each LABBOOK 2018 31

How do you manage pre-analytics – a critical worklow component? Do you have ixed time slots when you accept orders or do you react spontaneously and lexibly? At this point we do not provide a 24/7 LC-MS service. Pre-analytics is largely deined by the stability of the analyte. Cooled samples are analysed upon arrival. Emergency tests, such as examining urine samples for drugs, and samples with time-critical parameters, such as immunosuppressants, or amiodarone, or drug tests in capillary blood or urine in substitution patients are handled as soon as possible and deinitely on the same day. When did you begin to use LC-MS in your lab and what is its value? We introduced LC-MS in our lab in 2008, pretty much exactly ten years ago. From the very beginning we developed our own methods, primarily in the context of psychopharmaceuticals and drug abuse. Later, we also included hormones and metabolic products. The added value is, above all, that we can offer new kinds of analyses, which previously we had to outsource. Since we have been using HPLC-UV / VIS methods and ELISA tests with LC-MS we have recorded improved precision and an increase in throughput. Moreover, our own developments reduce price per piece as compared to commercially available kits and assays. In your lab, which samples or analyses are most frequent? This is clearly the detection of hormones such as calcifediol and steroids, but also TDM and drugs from capillary blood, blood, serum, urine and hair. With regard to LC-MS / MS at this point we solely use triple quads, two of them as hybrids with a linear ion trap, Otrap. The ion trap allows us to obtain structural information even in low concentrations. Triple quads offer high sensitivity and a larger dynamic range for exact quantiication while being tolerant in terms of matrix interferences. Short analysis cycles enable high sample throughput. The method was irst introduced a decade ago in 2008 Chemistry & Immunochemistry Currently used by the lab for forensic and clinical purposes, LC-MS primarily detects active ingredients in medication, hormones and drugs Which MS methods, such as sector ield, quadropole or TOF, does your lab use? Tandem mass spectrometry with triple quad and single quad with ICP-MS and GC-MS. Which instrument conigurations do you use? For LC-MS / MS we work with Sciex and Shimadzu, i.e. normally four pumps for online extraction; for GC-MS and GC-MS / MS we use Shimadzu, for ICP-MS we use PerkinElmer. Which parameters does your lab determine today with LC-MS and what are your plans for the future? Currently we use LC-MS primarily to detect active ingredients in medication such as psychopharmaceuticals, antiepileptic medication or immunosuppressants; hormones such as calcifediol and steroids; and drugs, both for forensic and clinical purposes from capillary blood, blood, serum, urine and hair. Interesting future parameters concern pharmaceuticals where a closer TDM, i.e. minimum blocking level, might be advantageous, for example in antibiotics; other areas are biomarkers, for example with regard to the thyroid, but also drugs in alternative samples. Sputum and breathing air might also be possible. Last, but not least, there is forensic toxicology – to diagnose driving ability, for example. Our lab is leading in terms of capillary blood. How did the team handle the transition to a more chemical / technical way of working? No problem at all; the team received the usual LC-MS training. Some colleagues were also trained in areas such as equipment maintenance or development and validation of methods. LABBOOK 2018 33

Chemistry & Immunochemistry URINE SCREENING Analyticon Biotechnologies – Urilyzer Flex Sample throughput: Chemistry: Up to 500 samples / h Sediment: Up to 90 samples / h Highlights: · Ideal for labs with max. 150 sediment and max. 250 chemistry samples per day · The automated sediment analysis leads to a standardization and consequently to an improved comparability of the results · Consolidated report and / or connection to LIS · Reduces the number of manual working steps and thus sources of error are minimized · Eficient worklow decreases hands-on BD Vacutainer Urine Collection System Dimensions: 13 × 75 mm / 4 mL volume 13 × 100 mm / 6 mL volume 16 × 100 mm / 8 – 11 mL volume Highlights: · This closed system offers a range of solutions for collection, transport and preservation of urine samples to meet the needs of each patient according to their age, health and mobility. · A wide range of tube volumes for microbiology and urinalysis determinations, with or without preser- vatives is available. · BD collection devices include specimen cups, 24 hour 3 L containers and transfer straws for all patient collection methods. LABBOOK 2018 35

Chemistry & Immunochemistry Sysmex – UC-3500 Sysmex – UF-5000 Sample throughput: Dimensions: Weight: Max. 276 samples / h 829 × 638 × 709 mm (h × w × d) 75 kg Sample throughput: Dimensions: Weight: 105 (urine), 20 (body luids) samples / h 855 × 760 × 754 mm (h × w × d) 90 kg Highlights: · User friendly and easy handling · Fully automated urine chemistry analysis · Fast total turnaround time (TAT) · Combination with the UF-5000 and the UD-10 for an optimal, fully automated urinalysis worklow · 11 test strip parameters including microalbumin and creatinine, and ive system parameters · Able to distinguish between RBC and haemoglobin thanks to the new CMOS sensor · High accuracy for speciic gravity (refractometry measurement method) and cloudiness Highlights: · Fully automated urine particle analysis · Modular concept: easy to combine with other members of the UN-Series for a fully automated urinalysis worklow · Integrated body luid mode · Small sample volume needed · Exclude negative UTI samples in less than a minute · Blue laser for better detection of bacteria · New depolarised side scatter light to differentiate RBC and crystals · Differentiation of epithelial cells & casts · Reliable QC management by our SCNS network Your Partner in Medicine and Science Worldwide Blood Collection & Diagnostic Products Medical Products & Transfusion Laboratory Automation & Devices Laboratory Products & Life Science www.sarstedt.com · info@sarstedt.com SARSTEDT AG & Co. KG · P.O. Box 12 20 · D-51582 Nümbrecht · Phone +49 2293 305 - 0 · Fax +49 2293 305 - 3992

Hematology & Pathology Blood Cell Counter Integrated Hematology Microscopy Hemosteasology Scanner Slide Preparation Printer Information Technology Other

Because of the help of these tools, the system achieves 93 percent first-pass yield, meaning that 93 percent of the time2, on average, a hematological result can be auto-validated after its first run on a DxH system. The right results the first time translates into no need for additional analyzers, hardware or expensive reagents to double-check the initial result. While this rate will depend on the laboratory’s patient population, protocols and decision rules, and a host of other factors, high first-pass yield is not the only efficiency-boosting fea- ture of the DxH 900. The system also demonstrates a high walkaway time – processing up to 640 cycles1 before any reagent changes are necessary. This is double the number of its predecessor system. This, combined with the fact that the system only requires four reagents versus nearly a dozen3 for other instruments, reduces the number of times laboratory technicians must interact with their instruments and frees them to spend time elsewhere. Analysis Revolutionary advancements in computing, electronics and manufacturing, along with continuous innovation in the areas of biotechnology, fluidics and mechanics, have led to a reduction in the size of analyzers. Progress outside of the field of hematology results in more tools and methods for hematological analysis. A short review of any hematology-focused scientific journal or congress showcases that many papers address combining traditional automated analysis and morphological slide review, with innovative flow cytometry analysis, genomics testing, advanced automated imaging processing and microfluidics. While many of these techniques are at the early stages of development and exist outside of routine core hematology laboratories, it will not be long before they become standard for any laboratory staff technologist. DxH 900 VCS 360 white blood cell scatter- and surface-plot Recently, Beckman Coulter launched the Aquios flow cytometer, fully automating the typically arduous sample preparation process for fluorescent cell analysis. Simultaneously, advanced computer algorithms have enabled automatic gating of fluorescent scatter plots; thus, for some results, this technology automates a task typically performed by highly trained clinicians, using a manual sample-by-sample approach. Because of this, the Aquios packs the power of fluorescent flow cytometry into a small system that operates like a traditional auto- mated hematology analyzer. These types of designs will democratize some advanced tests – moving them from limited, specialized, high-cost applications to everyday use and freeing clinicians and pathologists to focus on their most challenging samples. Hematology Monocyte population exhibiting heterogeneity and functional plasticity Clinical Information Management Innovation in the area of clinical information also promises to save laboratory time and labor, while enhancing patient care. As measure- ment and analytical tools improve – in particular, optics, electronics, computing algorithms and reagent systems – the insights into cellular health and physiology also grow. The power of cell morphology insights, for example, is evidenced by the CE mark of Beckman Coulter’s Early Sepsis Indicator*. This indicator relies on morphological changes of monocytes to alert clinicians of the possibility of developing sepsis in patients much earlier than traditional testing methods. Monocytes are among the first responders to infection, and changes in their size may presage the onset of the “cytokine storm” that is a hallmark of sepsis. Analysis of minute morphological changes – femtoliters in size across a population of monocytes – is enabled by core advances in VCS 360 technology, implemented in the DxH 900 hematology analyzer. This new flag helps address a key unmet clinical need – the ability to confidently assess sepsis risk shortly after entry to the emergency department. Studies have shown that for every hour earlier that antibiotics are administered, mortality rates can decrease by 7.6 percent4,5. Thus, by utilizing the Early Sepsis Indicator* as one part of the sepsis manage- ment strategy, hospitals can expect to treat patients earlier, saving lives and considerably, reducing the overall sepsis cost burden. New tools and parameters, such as the Early Sepsis Indicator*, will continue to emerge as the market competition increases and tech- nology evolves. Thus, the traditional concept of laboratory hematology will also evolve – to one leveraging a variety of orthogonal techniques to produce deeper clinical insights faster and at a lower cost than ever before. Indeed, this is an exciting time in the field, and the next five years should see seismic changes that promise to bring better patient care and more options for laboratory professionals. * CE Marked. Pending 510(k) clearance by the U.S. FDA. Not yet available for in vitro diagnostic use in the U.S. 1 C06947AB December 2017 DxH 900 IFU 2 DxH series side-by-side results documentation. 3 Competitor automated hematology analyzers, Instructions for Use (IFUs). 4 Kumar G, Kumar N, Taneja A, Kaleekal T, Tarima S, McGinley E, Jimenez E, Mohan A, Khan RA, Whittle J, Jacobs E, Nanchal R. Nationwide trends of severe sepsis in the twenty first century (2000-2007) 5 Chest. 2011;16:1223–1231. doi: 10.1378/chest.11-0352. [PubMed] [Cross Ref] LABBOOK 2018 41

Genrui – 5-Part Auto Hematology Analyzer KT-6610 Greiner – VACUETTE EDTA Tube Hematology Sample throughput: Dimensions: 60 tests / h 430 × 350 × 435 mm (d × w × h) Highlights: KT-6610 is a compact yet powerful hematology analyzer. It is an all-in-one solution for small labs and clinics with real 5-Part results. · Tri-angle laser scattering, flow cytometry for WBC differentiation and counting · 29 parameters + 4 scattergrams + 2 histograms · 10.4 inch touch screen · Built-in barcode scanner · Built-in printer, also support external printer · Three reagents for one test, Two Lyses are placed in the analyzer · Powerful flag information · One click solution for basic trouble shooting · QC assay file import Highlights: · EDTA tubes are offered as either K2EDTA or K3EDTA tubes · Contain (besides the K2EDTA) an inert barrier gel that is present in the bottom of the tube. · Plasma may be aspirated directly from the collection tube, eliminating the need for transfer to another container · VACUETTE EDTA tubes with separator gel improve the plasma yield and enable plasma to be left in the primary tube · This allows stability of certain parameters, when kept under specified conditions. · Also available with pre-attached barcode

Siemens Healthineers – ADVIA 2120i System Sysmex – XN-1500 (Count. Smear. Stain. All-in-one haematology) Hematology Sample throughput: XN-module CBC+DIFF: up to 100 samples / h, up to 40 samples / h in BF mode Dimensions: Sample throughput: Parameters: 860 × 1,410 × 680 mm (h × w × d) Up to 120 samples / h CBC incl. NRBC, 6-part white cell differential, reticulocytes, body fluids, and comprehen- sive morphology results Dimensions: Weight: Highlights: Highlights: The ADVIA 2120i System with Autoslide streamlines workflow by eliminating the majority of manual steps commonly performed to maximize productivity. Its unique testing methodology optimizes results while offering the simplicity and flexibility you need for easy integration into your lab. With connectivity to Aptio Automation and CentraLink Data Management System, it supports accurate, fast, sample processing with fully customizable, user-defined features. SP-50 module SP-50: up to 30 slides / h in S mode, up to 75 slides / h in H mode 1,006 × 1,053 × 855 mm (w × h × d) 211 kg · Fully integrated slide maker & stainer SP-50 · Flexible throughput depending on the workload · Automatic Reflex measurement in case of unreliable results · Reduced time for the preparation of the slides · Minimum need for manual tasks and less biohazard procedures · Small footprint · Optional integration of digital imaging module DI-60 · Reduced sample volume (for the smear preparation) · Staining protocols (SP-50): May Grünwald – Giemsa, Wright – Giemsa, Wright Sysmex – XN-L Series INTEGRATED HEMATOLOGY Beckman Coulter – HematoFlow Sample throughput: Dimensions: Weight: Highlights: CBC + DIFF up to 70 samples / h with the optional Speed-up licence 440 × 510 × 450 × 460 – 660 mm (h × w × d) (depending on model) 35 kg (XN-350, XN-450); 53 kg (XN-550 incl. sampler); 3 kg (XN-550 monitor) · XN-350: Single sample analysis in open mode · XN-450: Single sample analysis in closed or open mode · XN-550: Automated sampler analysis for increased workflow productivity: Rerun & Reflex and continuous loading · Add reticulocyte and body fluid analysis as you need them · XN quality. Cost-effective. Plus full support. · Delivering specialist solutions for labs that need to offer niche diagnostics. · A perfect secondary analyser · Upgrade from 3-part differential to 5-part differential at a price you can afford Highlights: HematoFlow is a unique cellular analysis solution which brings automated flow cytometry testing into the routine, mid to large haematology laboratory. When used in the HematoFlow solution with automated gating software, CytoDiff, a 5 colour, 6 monoclonal antibody reagent cocktail, yields more extensive results with a 16-part flow differential. With the HematoFlow, labs save time by reducing manual slide reviews. LABBOOK 2018 45

Hematology cigarette smoking and chewing gum within 24 hours prior to blood sampling can significantly affect the parameters to be analysed. These are strong recommendations with moderate quality evidence. Specific issues, such as drug monitoring, follow separate guidelines. All supplies, devices and equipment required for blood sampling should be available, their presence being verified by the person performing the sampling. This is a grade 2C recommen dation – weak recommendation, low quality evidence. Correct labelling of the tubes, however, is considered a 1C recommendation – strong recommendation, low quality evidence. Sampling The same grade, 1C, is accorded to the wearing of gloves during the actual sampling procedure. Applying a tourniquet is a strong recommendation with high quality evidence (1A). Selection of the adequate venepuncture site requires precise anatomical knowledge on the course of the arm veins. The authors consider this a strong recommendation with moderate quality Venous blood sampling — the sequence of steps Step Identify a patient Verify patient is fasting and properly prepared Obtain supplies required for blood collection Label / identify tubes Put an gloves Apply tourniquet Select venepuncture site Clean sampling site Puncture the vein Draw first tube Release the tourniquet Gently invert the tube once (one full inversion) Draw additional tubes following order of draw Remove needle from the vein and activate safety feature Dispose of the needle Bandage the puncture site Tell a patient to apply a gentle pressure for 5 – 10 min and not to bend the arm Invert all tubes 4 times Remove gloves Advise patient to rest for 5 min and ensure bleeding has stopped before leaving the side of venous blood collection Strength of evidence 1C 1B 2C 1C 1C 1A 1B 1B 1A 1A 1A 1B 1B 1A 1A 1C 1C 1B 1A 1B 1. 2. 3. 4. 5. 6. 7. 8. 9. 10. 11. 12. 13. 14. 15. 16. 17. 18. 19. 20. Glossary 1A Strong recommendation, high quality evidence (Benefits clearly outweigh risk and burdens or vice versa) 1B Strong recommendation, moderate quality evidence 1C (Benefits clearly outweigh risk and burdens or vice versa) Strong recommendation, low quality evidence (Benefits appear to outweigh risk and burdens or vice versa) 2A Weak recommendation, high quality evidence (Benefits closely balanced with risks and burdens) 2B Weak recommendation, moderate quality evidence (Benefits closely balanced with risk and burdens, some uncertainties in the estimates of benefits, risk and/or burdens) 2C Weak recommendation, low quality evidence (Uncertainty in the estimates of benefits, risks and/or burdens; benefits may be closely balanced with risk and burdens) www.uptodate.com/home/grading-guide#GradingRecommendations evidence (1B). Equally important, according to the authors, is thorough cleansing of the venepuncture site with 70 percent ethyl alcohol or any other appropriate disinfectant prior to sampling. Alcohol drying times and handling of the disinfected site are described in detail. The next steps, puncturing the vein either with the needle or a butterfly, drawing the blood into the first tube and releasing the tourniquet are strong recommendations with high quality evidence (1A). The authors, moreover, consider the order of draw of utmost importance: blood culture tube, citrate tube, plain tube or tube with clot activator, heparin tube, EDTA tube, glycolysis inhibitor tube (NaF or comparable) and other tubes. Another strong recommendation is inversion, 5 to 10 times, of the correctly filled sample tubes. Gentle removal of the needle and correct disposal in adequate containers is a strong recommendation with high quality evidence (1A). Subsequent treatment of the wound and asking the patient to apply pressure on the puncture site are strong recommendations with low quality evidence (1C).The tubes are inverted four more times, the gloves are removed and discarded. Correct removal of the gloves is considered a strong recommendation with high quality evidence. Post sampling After sampling, the patient should be advised to rest for about five minutes or he/she should be monitored by the person who took the sample until the bleeding has stopped. Communication with the patient that concludes the procedure is, according to the authors, a strong recommendation with moderate quality evidence. In a final section the authors discuss the implementation of the guidelines. Here, national laws and regulations which might pose an implementation barrier or challenge have to be considered. In order to successfully implement these guidelines on correct and error-free venous blood sampling a number of measures need to be taken. Staff has to be trained and refresher training has to be offered in regular intervals. Certification and regular recertification of the training as well as the actual performance of the procedure is useful. In the meantime audits are a suitable instrument to ensure long-term quality. For hospitals, the authors recommend an implementation team with a team leader who is familiar with all national laws, regu lations and recommendations and applies them resp. complies with them in the course of the implementation of the „Recommen dations on venous blood sampling“. The original publication, further relevant publications and material to support implementation (poster, presentation, video) can be found on the Working Group‘s resource/educational material page (https://www.eflm.eu/site/page/a/1194). Simundic A-M, Bölenius K. et al (2018), Joint EFLM-COLABIOCLI Recommendation for venous blood sampling, Clin.-Chem. Lab. Med., p. 1-24 Abstract: https://www.ncbi.nlm.nih.gov/pubmed/30004902 Pdf for download free of charge: https://www.degruyter.com/view/j/cclm.ahead-of-print/ cclm-2018-0602/cclm-2018-0602.xml LABBOOK 2018 47

MICROSCOPY Olympus – SC180 Olympus – BX53LED Hematology Highlights: · 18-megapixel camera with fast 4K Live image · Dedicated to precise sample documentation even at low magnifications · Assisted sample focusing and image noise cancellation Highlights: · Dedicated LED light source for microscopy The high-resolution, 18-megapixel SC180 color camera reveals your sample’s fine details and structures. The 18 million pixel count exploits the full optical resolution of the objectives, enabling you to make observations exclusively on-screen without using the eyepieces and fostering effective collaboration and audience engagement during full-screen presentations. With a fast 4K Live image, the SC180 camera accel- erates routine work, increases throughput in various applications through fast assisted focusing and noise cancellation, and makes the screen the new standard for documentation, evaluation, and discussion. (Olympus True Color LED) · Ergonomic design for intensive daily usage · Highly expandable frame to follow evolving application needs The BX53 microscope’s ergonomic design helps you stay comfortable during extended periods of use while the intuitive control layout enables fast, efficient obser- vation and imaging. Optimized for laboratory applica- tions, Olympus exclusive True Color LED illumination has a high luminosity and color rendering index so you can see samples in real-to-life colors avoiding color casts of generic LED light sources. HEMOSTEASOLOGY Greiner – VACUETTE Coagulation Tube HORIBA Medical – Yumizen G1550 Highlights: · With safety twist cap for an easy manual opening as well as automated opening using decapping instruments · Correct mixing ratio of venous blood a sodium citrate is ensured during blood collection, so that the tube contains one part sodium citrate solution to nine parts blood · Double-walled technology: the inner tube is made out of polypropylene (PP) and prevents the citrate solution from evaporating; the outer tube is made of poly ethylene terephthalate (PET) and ensures a long shelf-life for the vacuum Dimensions: Weight: Highlights: 1,000 × 600 × 900 mm (w × h × d) 85 kg The Yumizen G1550 is a fully automated, high-capacity coagulation analyzer. Thanks to its unique features, it manages the diagnostic requirements of clinical laboratories with mid to high workload: · Clotting, immunologic and chromogenic assays · Continuous loading · Full quality record for traceability · Pre calibrated tests · Liquid format reagents Combined with the complete range of HORIBA Medical Yumizen G reagents, the Yumizen G1550 provides a high quality and cost optimized solution. LABBOOK 2018 49

Siemens Healthineers – Sysmex CS-2500 System Siemens Healthineers – Atellica COAG 360 System Hematology Sample throughput Dimensions: PT and APTT: 350 (simultaneous analysis) 1858 × 1,042 × 1,415 mm (w × h × d), without LAS connection 2,156 × 1,042 × 1,415 mm (w × h × d), with LAS connection 600 kg (without LAS connection) 617 kg (with LAS connection) Dimensions: Sample throughput Weight: Approx. 685 × 1,113 × 895 mm (h × w × d) Approx. 180 simultaneous PT / APTT tests / h Approx. 140 kg Highlights: The Sysmex CS-2500 System– now available globally including the U.S. – offers mid-volume and multisite hemostasis labs smartly designed technologies for improved efficiency, exceptional accuracy, and reliable first-run results. Equipped with next-generation PSI technologies, the system takes hemostasis testing to the next level. The Sysmex CS-2500 System offers an expansive test menu of routine and specialty hemostasis assays (including several INNOVANCE assays), all on a single instrument. Weight: Highlights: The Atellica COAG 360 System* offers high-volume specialty hemostasis labs a transformative array of capa- bilities to streamline and unify hemostasis testing: · Five methodologies–clotting, chromogenic, immu- nologic, platelet aggregation and high-sensitivity immunoassay (LOCI) testing · Primary-tube sample-volume checks, advanced assay-specific sample quality checks for hemolysis, icterus and lipemia (HIL) interference. · Intelligent reagent and consumable management *Not available for sale in the US Sysmex – CS-1600 Sysmex – CS-2400/2500 Sample throughput: Dimensions: Weight: Assays: Up to 180 tests / h (PT) 685 × 775 × 895 mm (h × w × d) Approx. 110 kg 60 simultaneously Sample throughput: Dimensions: Weight: Assays: Up to 120 tests / h (PT) 540 × 760 × 690 mm (h × w × d) Approx. 85 kg 18 simultaneously Highlights: · Minimal need for hands-on maintenance · Perfect solution for medium-size labs with needs for specialty testing Highlights: · Advanced inhibitor testing with cross-mixing tests · CS-2400: open tube model, CS-2500: cap-piercing model · Rule-based rerun & reflex testing · Gold standard in “light transmission aggregometry” · Automated, high-accuracy platelet function testing by aggregometry · High-quality results based on advanced multi-wave- · Proven, reliable technical performance with advanced length technology CS-technology · Pre-analytic sample checks for interferences and · High-quality results based on advanced multi-wave- over-/underfilling length technology · Traceability for operation history and results · Consolidates routine and specialised testing in a single analysis system LABBOOK 2018 51

SCANNER Hamamatsu Photonics – NanoZoomer S210 Hamamatsu Photonics – NanoZoomer S60 Pathology Highlights: With over a decade of experience in digital pathology, Hamamatsu introduces the NanoZoomer S210. Highlights: Features: · 210 slide scanning capability · Batch scanning or continuous loading of slides · High performance · Cost-effective · Simple operation · New sleek design and small footprint NanoZoomer S60: The most flexible slide scanner for any histology lab – The best of Hamamatsu’s know-how, combining flexibility and outstanding image quality. Features: · High-speed and sensitivity in fluorescence · Best image quality both in brightfield and fluorescence · Double-size slides scan · Ideal for all research and pathology laboratories Hamamatsu Photonics – NanoZoomer S360 Olympus – UC90 4K Microscopy MICROSCOPY Highlights: · Real high throughput: Greatly improved throughput (more than 80 slides / h at 40 × mode for 15 × 15 mm sample sizes) and slide capacity of 360 for high work- load laboratories. · Hassle free: Simple operation and hassle free scanning. New, powerful scan software for fast and easy operation · Error free: Robust and stable scanning. Automatic system calibration. · Blur free: Sharp focus on entire specimen. Dynamic Pre-Focusing (DPF) method and advanced focus scoring with automated rescan option for higher success rate. Highlights: · Up to 4K UHD image capturing · One Camera for Multiple Applications · 9-megapixel CCD camera The 9-megapixel UC90 camera captures it all: brightfieldimages of superior quality, and up to 4K UHD imaging. Whatever your imaging needs are, expect no less than exceptional results in image quality, sensitivity, dynamic range, and color fidelity. The UC90 offers fluid sample navigation and focusing, making it effortless and convenient to locate regions of interest right on your screen. Excellent microscope imaging has never been as easy and versatile as with the UC90. LABBOOK 2018 53

INFORMATION TECHNOLOGY Hamamatsu Photonics – NDP.serve3 Image Server Software Visiopharm – QUALITOPIX Pathology Highlights: NDP.serve3 is the next generation of our established image server software. It is a power solution to share and manage whole slide images (WSI) across a network, either as a stand-alone solution or integrated with your LIS/LIMS software. Key Benefits / Features: · Secure database with enhanced security functionality · Intuitive, simple to use graphical user interface · Easy to share whole slide images · Seamless integration with NDP.view2 – Highlights: Novel & patented technology for monitoring staining performance in between EQA evaluations Coming Soon: A novel tool to measure and document your daily or weekly laboratory performance and ensure performance variations are kept at a minimum. the fastest Mac and Windows WSI viewer on the market Book a demo and opt in to win a Powerbank at http://bit.ly/2qVregp Visiopharm – ONCOTOPIX Visiopharm – ONCOTOPIX Quantitative Image Analysis Highlights: ONCOTOPIX Scan · Proven performance · Fast high quality slide scanner ONCOTOPIX Dx · Validated Dignostic Decision Support · Automated Workflows ONCOTOPIX Discovery · Dedicated tools for cancer research Scanners produced by Hamamatsu Book a demo and opt in to win a Powerbank at http://bit.ly/2qVregp ONCOTOPIX Quantitative Image Analysis Highlights: Leading IA solution for cancer diagnostics providing: · Unprecedented high-precision alignment · Automated tumor cell detection · Enabling Multiplexing and co-localization analysis · For protein and ISH test results as well as H&E · Revealing information about Tumor Micro Environment Book a demo and opt in to win a Powerbank at http://bit.ly/2qVregp * Validated for in vitro diagnostic use (CE-IVD) in Europe in combination with the CE-IVD APPs from Visiopharm LABBOOK 2018 55

AMPLIFICATION BIORON Diagnostics – RealLine Pathogen Diagnostic Kits Orion Diagnostica Oy – Orion GenRead DNA Highlights: RealLine Pathogen Diagnostic Kits from BIORON Diagnostics – with outstanding features: · Lyophilized mastermixes · One handling procedure for all kits – simple & fast · Same PCR cycling conditions · Controls included · Multiplexing kits For a wide range of parameters: · STIs: CT, NG, Mycoplasma ssp., Ureaplasma ssp., Gardnerella, Trichomonas · TORCH: Toxoplasma and Rubella · Herpes-viruses: CMV, HSV-1 and -2, EBV, VZV · Tick-borne infections: Borrelia and TBEV (FSME) · HPV: kits for HR and LR Human Papilloma Virus types Assays: C difficile, campylobacter Highlights: Orion GenRead system is a small benchtop system for molecular pathogen detection, based on proprietary technology SIBA (Strand Invasion Based Amplification). · Flexibility with 1 – 12 samples in one run · Fast test results are available in less than one hour · Ready to use kits contain all needed reagents · Bi-directional HIS / LIS connectivity · Portable and robust instrument suitable for various laboratory settings · CE marked test kits for C difficile and campylobacter. Next: RSV and Influenza A&B Sarstedt – White Multiply PCR Plates Siemens Healthineers – Fast Track cycler Highlights: · White wells for improved fluorescence reflection · Thin-walled reaction tubes for quick temperature transfer · Free from DNA, DNase, RNase and PCR inhibitors · Barcode labeling on plates with half or full skirt is available on request Dimensions: Weight Highlights: 130 × 150 × 150 mm (w × h × d) 2 kg Compact, real-time PCR platform enables laboratories of all sizes to implement molecular testing with simplicity and speed. · Compact design fits in any laboratory · Robust technology using rotray magnetic induction · Wireless connectivity connects up to 10 FTCs · High throughput workflow supports up to 480 reactions LABBOOK 2018 57

LIQUID BIOPSY BD / QIAGEN PAXgene Blood ccfDNA Tube Streck – Cell-Free DNA BCT CE DNA Dimensions: 16 × 100 mm / 10 mL volume Highlights: Dimensions: 16 × 100 mm, 9.0 ml draw Highlights: A complete, integrated preanalytical workflow solution for circulating cell-free DNA · Non-crosslinking preservation of ccfDNA levels · Seamless integration with proven ccfDNA isolation kits · Streamlined with primary tube sampling during auto- mated processing · Designed for sensitive research assays, including analysis of circulating tumor DNA and non-invasive prenatal testing · Sample transport and storage at room temperature for up to seven days · Unique direct draw blood collection tube which stabilizes nucleated blood cells · Prevents the release of genomic DNA, allowing isolation of high-quality cell-free DNA and CTCs for clinical research studies, drug discovery and diagnostic assay development · Cell-Free DNA is stable for up to 14 days and CTCs are stable for up to seven days, at room temperature, allowing convenient sample collection, transport and storage · Available in a unique hybrid plastic tube which protects valuable reagent and samples RESEARCH USE ONLY (RUO) Streck – Cell-Free RNA BCT Eppendorf – BioSpectrometer fluroescence Dimensions: 16 × 100 mm, 10.0 ml draw Highlights: · Unique direct draw blood collection tube, which stabilizes cell-free RNA in plasma and prevents the release of non-target background RNA from blood cells during sample processing and storage. · Cell-Free RNA is stable for up to seven days, at room temperature, allowing convenient sample collection, transport and storage · Unique hybrid plastic tube to protect valuable reagent and samples Dimensions: Weight: Power consumption: 50 × 295 × 400 mm (h × w × d) 5.4 kg 15 W (during operation), 5 W (dimmed display) Highlights: · Absorbance measurement for one or more wave- lengths, recording of wavelength scans · Sensitive nucleic acid and protein quantification via fluorescence intensity · Integrated application and results memory · Compatible with microliter measuring cells, such as the Eppendorf µCuvette G1.0, and standard cuvettes LABBOOK 2018 59

Microbiology Mass Spectrometry Identification / Susceptibility Microscopy Other

Microbiology tem for Shimadzu with the launch of the MALDI- 8020, a compact benchtop linear MALDI-TOF mass spectrometer with class-leading performance. The MALDI-8020 is the newcomer to the Shimadzu family of MALDI products. It combines talents and skills such as outstanding speed, accuracy, and performance. It targets labs specializing in scientific research, as well as labs where quality control methods or rapid screening of intact samples are routine. Linear MALDI-TOF instruments have traditionally been regarded as low performance, capable only of average mass determination with low resolution. The MALDI-8020 breaks that perception. Innovative instrument design and technological advances have allowed the size of the instrument to be reduced while maintaining the performance specifications of the equivalent larger floor-standing Axima model. Ideal for researchers developing MALDI-based diagnostic methods With the higher-throughput capability of the MALDI-8020, simple and secure software is required to manage automated MALDI-TOF data acquisition. From the creation of sample worklists using SampleStation to the automated data acquisition controlled by AuraSo- lution, these easy-to-use software applications make MALDI-TOF MS amenable to laboratories which may not have considered this technique before. MALDI-8020 with the MALDIsolutions software Integrated software security features provide user-access control within the software applications, ensuring that data and acqui- sition methods are protected from unauthorized changes. From creating individual user login accounts to assigning permitted roles, the system administrator has full control over who has access and what functions they are permitted to perform. As part of the security features, the software provides traceability, indicating when (and by whom) changes to the worklists were made, when samples were analyzed and whether re-analysis has been performed. FlexiMass-DS sample slides with barcode Using the SampleStation software, sample worklists are prepared indicating positions of the samples on the MALDI slide and associated sample information. The sample worklists are assigned a unique slide identifier e.g. the slide barcode on the single-use, individually barcoded FlexiMass-DS sample slides, and this information is saved to a secure SQL database. An integrated barcode reader scans the slide barcode as it is inserted into the instrument, ensuring that the correct sample worklists are retrieved and analyzed. MALDI-TOF MS Quality Control (QC): Another application targeted by the MALDI- 8020 is MALDI-based quality control. The QC Reporter software provides a complete solution, from sample list to report generation. The QC criteria can be used to customize the experiment for different applications and include mass tolerance, signal-to-noise threshold, minimum resolution of the target mass and acceptance limits for adducts and impurities. The results of the QC analysis are displayed in a simple user-inter- face and are color-coded to indicate the test result (pass, query, fail). From here, the operator can review the detailed results before exporting as PDF reports. With the release of the MALDI-8020, Shimadzu is able to offer an affordable, easy-to-use, benchtop MALDI-TOF mass spectrometer designed to meet current market demands for routine MALDI workflows. CONTACT Shimadzu Europa GmbH Albert-Hahn-Straße 6-10, 47269 Duisburg, Germany phone: +49 203-76 87 0 · fax: +49 203-76 66 25 shimadzu@shimadzu.eu · www.shimadzu.eu LABBOOK 2018 63 Rapid sample introduction through the use of a load-lock system

IDENTIFICATION / SUSCEPTIBILITY FUJIFILM Wako – Toxinometer MT-6500 Sysmex – UF-5000 Microbiology Dimensions: Weight: Assays: 350 × 420 × 356 mm (w × h × d) 14 kg ß-Glucan Test for the detection of invasive fungal infection Highlights: · Quantitative ß-D-glucan measurement by kinetic turbidimetric LAL method · 16 samples positions, up to 64 positions using MT-6500 Extension Modules · Operation of monotest reagents · Calibration by QR code scan · LIS integration capability · Quality control available · Maximum 90 minutes measurement time Sample throughput: Dimensions: Weight: Up to 105 (urine), 20 (body fluids) samples / h 855 × 760 × 754 mm (h × w × d) 90 kg Highlights: · Fully automated urine particle analysis · Complete sample analysis in less than a minute · Precise detection of bacteria · Exclude negative UTI samples with up to 100 % NPV · Substantial culture reduction · Differentiation of gram negative and gram positive bacteria, enabling more specific antimicrobial treatment in real time · Integrated body fluid mode · Modular concept: Combine with other members of the UN-Series for a fully automated urinalysis workflow MICROSCOPY Olympus – CX33 OTHER BD Vacutainer Urine Tubes for Microbiology Highlights: · Maintenance free Koehler illumination with LED · Fully ergonomic design The CX33 microscopes enable users to remain comfor table during long periods of routine microscopy observations. The microscope frame conforms to the user’s hands and the location of the control knobs maximize ergonomics to improve work efficiency. Users can quickly set a specimen with one hand, while adjusting the focus and operating the stage with the other hand with minimal movement. A fixed Koehler illumination system provides detailed images while minimizing the need for maintenance and the possibility of operator errors. The microscope also features an optional camera port for digital imaging. Dimensions: 13 × 75 mm / 4 mL volume 16 × 100 mm / 10 mL volume Highlights: · BD offers a range of tube types with boric acid based preservatives all clinically validated to provide 48 hour specimen stability at room temperature. · BD Urine System has been proven to have a three times greater chance of achieving accurate urinary tract infection results over an open system. · Introduction of closed system has been shown to decrease contamination rates by 19 percent. · Research has shown a ten percent lower incidence of bacterial overgrowth and thus reduces the possibility of false positive results. LABBOOK 2018 65

Microbiology While such use of the biomarker is in its early stages, data so far indicates that the test is a useful guide to the introduction of anti-fungal therapy in those areas. Sanguinetti, who is also President Elect and Secretary General of ESCMID (European Society of Clinical Microbiology and Infectious Diseases) and Chief of the Department of Laboratory Sciences and Infectious Diseases, added that abdominal surgery is a common procedure at the hospital but is an area where patients are at risk of candidemia, while patients with rheumatological diseases such as lupus, are also at risk of fungal infections and aspergillosis. Monotest advantage in emergencies With the new Fujifilm Wako turbidimetric assay, he said there are technical advantages, in particular that the test is always available with results obtained within one hour. “The most important advantage for the Fujifilm Wako test,” he added, “is that it is possible to perform a single test. These tests are especially useful in emergency situations. This is not possible for the Fungitell test because we need to include at least ten samples in the run. With Fujifilm Wako, it is possible to include a single test – a huge advantage for the lab and clinician.” The Toxinometer MT-6500 based β-Glucan Test is an in vitro diagnostic test for the quantitative determination of (1→ 3)-β-D-glucan in serum or plasma. The new test is also advantageous for hospitals that do not work directly with labs, or those needing an immediate result from an emergency patient, or those hospitals with not so many requests for β-glucan. As Sanguinetti points out, “If I need to perform only two tests a day, which is possible in a small hospital, these can be perfectly performed by the Fujifilm Wako test.”

BLOOD GLUCOSE Lifotronic – H8 Hemoglobin Analyzer Lifotronic – H9 Hemoglobin Analyzer POCT Highlights: Reliable partner for diabetes test · Ion-Exchange HPLC · Gold standard methodology for HbA1C · 130 seconds / test (Variant mode) · High precision, CV ≤ 1.5 % · 10 sample positions · Variant hemoglobin detection · HbA1a/b, LA1c, HbF, A1c, A0 · No sample preparation required · NGSP and IFCC certified Highlights: Reliable partner for diabetes test · Ion-Exchange HPLC · Gold standard methodology for HbA1C · 72 seconds / test (Fast mode) · High precision, CV ≤ 1.5 % · 110 sample positions · Variant hemoglobin detection · HbA1a/b, LA1c, HbF, A1c, A0 · No sample preparation required · NGSP and IFCC certified

COAGULATION BLOOD GASES, ELECTROLYTES, OXIMETRY Siemens Healthineers – Xprecia Stride Coagulation Analyzer Siemens Healthineers – epoc Blood Analysis System POCT Dimensions: Weight: Highlights: 70 × 170 × 40 mm (w × h × d) 0.3 kg The Xprecia Stride Analyzer for PT / INR testing provides four key benefits for testing at the point of care: Usability is enhanced by a bright, interactive touchscreen with step-by-step user instructions; Safety is addressed with the strip eject button to reduce potential biohazard exposure; Efficiency is enabled with ergonomic design and easy sample application; and Accuracy is supported by using the same reagent for the strips used by many central lab analyzers. Product availability varies by country Assays: Dimensions: Weight: Highlights: pH, pCO2, pO2, Na+, K+, Ca++, Cl-, Glu, Lac, Crea, Hct 77 × 27 × 147 mm (w × h × d) Host: Reader: 85 × 50 × 215 mm (w × h × d) Host: 0.359 kg / Reader: < 0.5 kg The epoc Blood Analysis System is a handheld, wireless solution that provides blood gas, electrolyte and meta- bolite results at the patient’s side in less than one minute. Deliver pH, pCO2, pO2, Na+, K+, Ca++, Cl-, Glu, Lac, Crea, Hct, TCO2*, BUN* while empowering clinicians to make faster decisions with lab-quality results to improve patient outcomes. * Not available for sale in all countries. Due to local regulations not all products are available in all countries. Siemens Healthineers – RAPIDLab 348EX Blood Gas System Siemens Healthineers – RAPIDLab 1200 Blood Gas System Assays: Dimensions: Weight: Highlights: pH, pCO2, pO2, Na+, K+, Ca++, Cl-, Hct Assays: 385 × 382 × 353 mm (w × h × d) 9.4 kg The RAPIDLab 348EX Blood Gas System is a cost-effec- tive solution for low-volume laboratory settings. Report accurate patient results from a whole-blood sample in 60 seconds, with minimal operator interaction. Increase operator efficiency with bar-code data entry of patient and operator IDs, automatic sample aspiration and calibrations. Not available for sale in the U.S. Product availability varies by country. Dimensions: Weight: Highlights: pH, pCO2, pO2, Na+, K+, Ca++, Cl-, Glu, Lac, Neonatal Total Bilirubin, CO-oximetry 230 × 240 × 610 mm (w × h × d) Siemens RAPIDLab 1200 Blood Gas System is uniquely designed to meet high-volume critical-care testing needs. The system has an ultra-fast sample processing and microsample capability, with results in 60 seconds. Cartridge-based reagent system simplifies operation, and Ready Sensor technology offers reliability with minimal maintenance. Product availability varies by country. LABBOOK 2018 71

Siemens Healthineers – Atellica 1500 Automated Urinalysis System Siemens Healthineers – CLINITEK Status Connect System POCT Sample Throughput: Assays: Dimensions: Weight: Highlights: 106 – 240 samples /h Bilirubin, Clarity, Color, Glucose, Ketone, Leukocyte esterase, Nitrite, Occult blood, pH, Protein, Specific gravity, Urobilinogen, Albumin, Albumin-to-creatinine ratio, Creatinine, Protein-to-creatinine ratio 1,260 × 625 × 680 mm (w × h × d) 114 kg Combining the CLINITEK Novus Analyzer and the new Atellica UAS 800 Analyzer* into one completely automated unit, the Atellica 1500 Automated Urinalysis System sets the new standard for accuracy and efficiency. It is a truly digital automated urinalysis system, and lets you manage more samples with less staff in shorter time, while never compromising on high-quality results. Not available for sale in the U.S. Product availability varies by country. Assays: Dimensions: Weight: Highlights: Albumin, Bilirubin, Creatinine, Glucose, Ketone, Leukocytes, Nitrite, pH, Protein, Specific gravity, Urobilinogen, Albumin-to- creatinine, hCG 171 × 185 × 272 mm (w × h × d) 2.3 kg The CLINITEK Status Connect System provides flexible connectivity solutions, data integration, and operational control to improve risk management at the point of care. Latest software includes WPA2-PSK wireless security and encryption. Auto-checks help to eliminate errors, mitigate risks, and support compliance. The automated analyzer is faster than manual testing, and helps reduce the chance of human error. Product availability varies by country. INFORMATION TECHNOLOGY OTHER Siemens Healthineers – POCcelerator Data Management System INPECO SA – PROTUBE Highlights: Connect securely with an open, reliable POC informatics platform. Gain vendor independence and free choice in selecting the appropriate POCT device to meet your clinical requirements. Create a long-term solution that saves time and money by simplifying the complexity and cost of maintaining multiple IT systems. Product availability varies by country. Highlights: · ProTube is the smart solution to avoid pre-lab errors that ensures the full traceability of the biological samples throughout the collection process. · ProTube enables the correct match of right patient with the right tubes, applies the right label, closes the patient loop with the samples validation and their transportation. · ProTube is available also in a mobile version with a handheld device for assisting in sample collection at the Point of Care environment. LABBOOK 2018 73

Information Technology LIS, Middleware, POCT Inventory Management Specialties

Information Technology what prices? And finally the support of physical interfaces has to be ascertained: are popular interface protocols such as HL7/IHE or ASTM used and how are they integrated in the lab instruments on the practical level. Programming customized device interfaces is the core business of most vendors and can over the course of the years amount to several thousand euros per analyzer – a significant position in the budget. The interface issue is also relevant in terms of background pro- cesses such as billing and controlling or external communication with physicians’ offices to exchange order data and results. Functional criteria Many of the modules listed in the table under “Functions” are now being offered by every vendor. Nevertheless it does make sense to look into the procedures and review how they are controlled by master data and parameters. Today it is important to consider that many lab workflows have to meet certain standards. Quality management standards or ISO 15189, 17025 or even ISO 22870 for POCT are more or less obvious; others such as GMP for blood donations or those for own blood donations are less well known. FEATURE EXPL ANATION Size, financial position Number of permanent and freelance staff, revenue, core business Continuity, accountability / responsibility Type of company, year of incorporation, guarantees, ISO certification Reference customers Number, size, scope, reputation Customer testimonials Adherence to deadlines and delivery schedules, keeping promises, commitment of the staff, cooperation with manufacturers of instruments, LIS and HIS Soft skills Personality and competence of the vendor’s staff during a conversation Implementation concept Is it comprehensible? volume, visualization of the solution Service Training Architecture Hardware Software Response time Hotline, response time, availability of specialists Documents, online support, on-site training, seminars Client-server architecture, periphery, central master data server Central computer, PC network, terminals, printers, storage space, operating system Data base, data protection / privacy concept and confirmations, use of standard software, customization of parameters (by user) Depending on volume of data in the database, number of web connections and online users (particularly relevant for multi-site facilities) Maintenance contracts Type and scope, hardware, software, remote access License policy Modules Online devices, database, multiple installations (campus license), pay-per-use (instead of purchase) Clinical chemistry, microbiology, blood bank, pathology, billing, order entry, automation and control Data protection / privacy concept Permission-based, controlling access to patient data (e.g. lab values) Tracking Compliance Search and sort functions, order status and sample tracking RiLi-BÄK (in Germany), ISO 15189, ISO 17025, ISO 22870, GMP, etc. Master data management Data maintenance, parameters, copying, use of legacy data, across modules Order entry and capturing of results Keyboard, card reader, order entry, material ID, different bar codes, device interfaces Quality control RiLi-BÄK (Germany), Westgard, other quality systems, visualization Technical and medical validation Autovalidation, rules, alarms, automated repeat measurements, visualization Reading Billing Archiving Statistics Sort criteria for orders and lab, rules systems, ICD codes, footnotes in identical texts Multi-client capability, service portfolio, accrued accounts Procedure, duration, access, reactivation, archiving of image data Saved and spontaneous queries, SQL assistant, export to standard software Configurability Adaptation of software and user screens to the on-site situation Internal communication Link to HIS and departments/wards, POCT devices, decentral printers, standard interfaces can be configured (HL7, IHE, LDT, ASTM) External communication Link to other hospitals, specialist physician labs, lab groups hardware Existing data Use of existing printers, scanners, PC, receipt readers Use of legacy data, retaining the identification logic Y N A P M O C T C U D O R P Y T I L A N O I T C N U F N O I T A R G E T N I S Costs Acquisition costs incl. commissioning, database, operating costs T L U S E R Own contributions Which contributions are required (configuration, AP computer, preparation of hardware and server), database license, training by in-house staff Costs over a period of five years These costs indicate whether a Europe-wide tender is required Figure 1: Checklist for the selection of a lab information management system LABBOOK 2018 77

Information Technology Beckman Coulter – DxONE Command Central Workstation i-SOLUTIONS Health – LabCentre Highlights: Beckman Coulter’s DxONE Command Central remote monitoring system helps manage lab workflow and improve decision-making steps. Connecting up to 18 instruments or automation systems, and up to five networked DxONE Command Central workstations within a single laboratory, this increase in flexibility allows the operator to place DxONE Command Central workstations in prime locations for optimum laboratory management. DxONE Command Central provides lab technicians with a real-time view of laboratory systems from a single point of control to maximize workflow efficiencies. DxONE Command Central works with data managers such as REMISOL Advance to achieve workflow efficiencies, or can serve as a stand-alone product for users to monitor automation and / or multiple analyzers and quickly respond to any instrument issues. In addition to serving labs that don’t utilize data manage- ment software, DxONE Command Central provides an opportunity to apply other Beckman Coulter information systems and workflow solutions all while keeping an eye on what is going on in the lab. Highlights: LabCentre is a market-leading laboratory and pathology information management system. It helps doctors, scientists, technologists and management staff to track samples and testing processes, communicate results to other health professionals, and monitor costs and reporting. LabCentre supports the following disciplines: · Blood Sciences · Microbiology · Hygiene · Transfusion Medicine · Pathology · Billing Medat – Laboratory Information System Highlights: · Flexible, private company with 50 employees. · Complete solution from order entry to billing. · Tailor-made modules for microbiology, virology, environmental hygiene, cytopathology, histo- pathology, clinical chemistry, serology / toxicology and blood banking · Single, integrated system for all divisions and sites. · Reliable operation in some of Europe’s biggest laboratories. Integrated solution management for your laboratory dr. neumann kindler & www.labcore.de LABBOOK 2018 79

Non-Diagnostic Blood Collection Pipette Tips Compressors Specialties

PIPETTE TIPS COMPRESSORS SARSTEDT – Low Retention Pipette Tips Dürr Technik – SICOLAB – compressor stations Non-Diagnostic Highlights: · Minimising sample loss · Optimised surface for enhanced dispensing behavior · Improved sample recovery · Minimal sample loss of highly viscous liquids or samples containing detergents · Cost savings in valuable reagents Air flow: Compressed air quality: Up to 145 l / min at 5 bar Up to 1:3:1 (according to ISO 8573-1) Highlights: · Oilfree compressed air for many applications · Silent – thanks to excellent soundproofing (48 – 54 db [A]) · Compact – fits under the laboratory bench · Mobile – with wheels or handling grips · Wide variety of versions · Membrane dryer and filters as options SPECIALTIES BANDELIN – SONOPULS - Ultrasonic homogenisers series HD 4000 BANDELIN – SONOSHAKE - Ultrasonic bath combined with shaking device Highlights: Homogenisers are mainly used for homogenising, desagglomerising, emulsifying, suspending, acceleration of chemical reactions as well as for disruption of cells, bacteria, fungi or spores. Significantly reduced processing times and quickly available results make the ultrasonic homogenisers indispensable for modern processes and in analysis. Using ultrasonic homogenisers certain substances can be selectively destroyed, tedious preparation processes can be shortened and results of many reacions are improved. Highlights: SONOSHAKE offers a wide range of applications for sample preparation in many areas of analysis, for example, in environmental and foodstuffs analytics as well as in the area of medical diagnostics. Sedimen- tation in the sample can be solved by defined shaking. An additional sonication allows a good homogenising. The shaking device SA 1028 can be added to existing ultrasonic bath DT 1028 F. LABBOOK 2018 83

g n i s s e c o r P e l p m a S ■ n o i t a m o t u A ■ A u t o m a t e d S a m p l e P r o c e s s i n g 4 8 4 Page Index Alsachim, a Shimadzu group company 160 rue Tobias Stimmer 67400 Illkirch, France phone: +33 390 402 200 contact@alsachim.com www.alsachim.com Analyticon Biotechnologies AG Am Mühlenberg 10 35104 Lichtenfels, Germany phone: +49 6454 7991-0 · fax: +49 6454 7991-30 info@analyticon-diagnostics.com www.analyticon-diagnostics.com ASP Lab Automation AG Rugenranzel 4 25373 Ellerhoop, Germany phone: +49 4120 70679-27 info@asplabauto.com www.asplabauto.com Atlas Genetics Ltd White Horse Business Park, Derby Court, Epsom Square Trowbridge BA14 OXG, UK phone: +44 (0) 1225 71930 info@atlasgenetics.com www.atlasgenetics.com BANDELIN electronic GmbH & Co. KG Heinrichstraße 3-4 12207 Berlin, Germany phone: +49 30 76880-0 info@bandelin.com www.bandelin.com BD Business Park Terre-Bonne, Bât A4 Route de Crassier 17 1262 Eysins, Switzerland phone: +41 21 556 30 00 pas_info@bd.com · bd.com Beckman Coulter, Inc. 250 S. Kramer Boulevard Brea, CA 92822, USA phone: +1 714 9935321 cvillarreal@beckman.com www.beckmancoulter.com BIORON Diagnostics GmbH Rheinhorststraße 18 67071 Ludwigshafen, Germany phone: +49 621 545900-70 info@bioron.de www.bioron.de biostep GmbH Innere Gewerbestraße 7 09235 Burkhardtsdorf, Germany phone: +49 3721 3905-0 info@biostep.de www.biostep.de · www.biostep.org BIOSYSTEMS S.A. Costa Brava 30 08030 Barcelona, Spain phone: +34 93 311 00 00 biosystems@biosystems.es www.biosystems.es COMED Computerorganisation in der Medizin GmbH Köttersweg 11 59494 Soest, Germany phone: +49 2921 9630-0 comed@comed-com.de www.comed-com.de DiaSys Diagnostic Systems GmbH Alte Straße 9 65558 Holzheim, Germany phone: +49 6432 9146-0 info@diasys.de www.diasys-diagnostics.com y r t s i m e h c o n u m m I & y r t s i m e h C ■ 16 35 16 35 16 18 22 24 25 29 35 31 18 Companies & Suppliers i c i t s o n g a D - n o N ■ 83 84 82 y r t e m o r t c e p S s s a M ■ l y g o o t a m e H ■ l y g o o h t a P ■ A N D ■ l i y g o o b o r c i M ■ l y g o o n h c e T n o i t a m r o f n ■ I T C O P ■ 72 72 52 59 65 42 45 57 78 79 80 19 70 LABBOOK 2018 85

g n i s s e c o r P e l p m a S ■ n o i t a m o t u A ■ 8 Page Index ibidi GmbH Am Klopferspitz 19 82152 Martinsried, Germany phone: +49 89 5204617-0 info@ibidi.de www.ibidi.com INPECO SA Via Torraccia 26 6883 Novazzano, Switzerland annalisa.leonardo@inpeco.com www.inpeco.com i-SOLUTIONS Health GmbH Am Exerzierplatz 14 68167 Mannheim, Germany phone: +49 621 3928-0 · fax: +49 621 3928-527 info@i-solutions.de www.i-solutions.de JADAK Europe Emmastraat 16 4811 AG Breda, The Netherlands phone: +31 76 522 5588 info@jadak.eu www.jadak.eu KUGEL medical GmbH & Co. KG Hermann-Köhl-Straße 2 A 93049 Regensburg, Germany phone: +49 941 208648-0 info@kugel-medical.de www.kugel-medical.de Lifotronic Technology Co., Ltd 4th Floor, Building 15, 1008 Songbai Road Nanshan District 518055, Shenzhen, China phone: +86 755-2906 00 26 inter-marketing@lifotronic.com · en.lifotronic.com Medat Computersysteme GmbH Albrechtstraße 14 80636 München, Germany phone: +49 89 126808-0 info@medat.de www.medat.de MIKROGEN GmbH Floriansbogen 2-4 82061 Neuried, Germany phone: +49 89 54801-0 mikrogen@mikrogen.de www.mikrogen.de SHENZHEN MINDRAY Bio-Medical Electronics Co., LTD. Mindray Building, Keji 12th Road South, High-tech Industrial Park, Nanshan 518057 Shenzhen, China intl-market@mindray.com · www.mindray.com Molzym GmbH & Co. KG Mary-Astell-Straße 10 28359 Bremen, Germany phone: +49 421 696 162-15 info@molzym.com www.molzym.com Olympus Europa SE & Co. KG Amsinckstraße 63 20097 Hamburg, Germany phone: +49 40 23773-0 ScientificSolutions@olympus-europa.com www.olympus-lifescience.com Orion Diagnostica Oy Koivu-Mankkaantie 6 B 02200 Espoo, Finland phone: +358 10 4261 orion.diagnostica@oriondiagnostica.fi www.oriondiagnostica.com Companies & Suppliers i c i t s o n g a D - n o N ■ 84 l y g o o n h c e T n o i t a m r o f n ■ I 79 79 T C O P ■ 73 74 69 72 74 y r t s i m e h c o n u m m I & y r t s i m e h C ■ y r t e m o r t c e p S s s a M ■ l y g o o t a m e H ■ l y g o o h t a P ■ A N D ■ l i y g o o b o r c i M ■ 25 26 21 26 27 29 54 44 48 58 49 53 54 65 57 70 LABBOOK 2018 87

NEW THE RIGHT RESULTS, THE FIRST TIME Avoid inefficiencies with a 93% first-pass yield1 When important patient care decisions are on the line, you need results you can count on—the first time. The DxH 900 hematology analyzer first-pass yield enables predictable costs and maximizes staff time by: › Delivering accurate results with fewer reruns using near native-state cellular characterization and DataFusion technology—a unique combination of multiple testing methods for precise, high-resolution analysis in a single run › Ensuring predictable costs through industry-leading 93% first-pass throughput1 for accurate flagging and a reduced number of slide reviews › Maximizing staff time by reducing the time and supply costs related to managing systems with higher repeat rates, and simplifying workflow through a lean reagent portfolio Learn more about how laboratories can achieve Lean practices and minimize repeat rates with the DxH 900 analyzer. Visit www.beckmancoulter.com/dxh900-EH 1. Percentage of samples with numerical results that do not require additional intervention or handling, such as manual smear review, spun hematocrit, dilution, or other repeat/reflex testing. DxH series side-by-side results documentation. © 2018 Beckman Coulter, Inc. All rights reserved. Beckman Coulter, the stylized logo and the Beckman Coulter product and service marks mentioned herein are trademarks or registered trademarks of Beckman Coulter, Inc. in the United States and other countries. For more information, visit www.beckmancoulter.com/contact AD-127201 93%