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Your guide to laboratory and pathology equipment in Europe € 15.– Automation & Sample Processing Chemistry & Immunochemistry Hematology Pathology DNA Microbiology POCT Non-Diagnostic 2017 IT MAGLUMI 4000 Plus, as a new member of MAGLUMI Chemi luminescence Immunoassay (CLIA) analyzers, shares 138 parameters of MAGLUMI reagents which feature stateoftheart illumi nation and separation technologies. Comprehensive test menus help your lab to do more with less and specialty immunoassays.
Imprint published by EUROPEAN HOSPITAL VERLAGS GMBH Theodor-Althoff-Straße 45, 45133 Essen, Germany phone: +49 201 871268-51 fax: +49 201 871268-64 info@european-hospital.com www.healthcare-in-europe.com & DR. NEUMANN & KINDLER LTD. & CO. KG Herner Straße 324, 44807 Bochum, Germany phone: +49 234 9571969-0 info@labcore.de www.labcore.de EDITOR-IN-CHIEF Markus Neumann CONTRIBUTING WRITERS John Brosky, Michael Krassnitzer, Mark Nicholls EXECUTIVE DIRECTOR Daniela Zimmermann LAYOUT AND GRAPHIC DESIGN Christoph Muschiol, Dorfen, Germany ADVERTISING Gavin Hua (China) Eric Jund (E, F, I) Simon Kramer (B, GB, L, NL) Ralf Mateblowski (D, A, CH) Jane Park (Korea) Hanna Politis (U.S.A, Canada) Charles Yang (Taiwan) SUBSCRIPTION Liane Kaiser, kaiser@european-hospital.com, Subscription rate: € 15,– plus postage PRINTED BY SAFNER Druck und Verlags GmbH, Priesendorf, Germany DISCLAIMER The information and opinions expressed in articles and product entries published in LABBOOK are solely those of the manufacturers / companies, their authors and contributors, for which the publisher holds no responsibility. All trademarks, product names, company names and logos in this publication are the property of their respective holders. Users must obtain permission from those holders before copying or using the owner’s trademarks, product and company names or logos. Errors and omissions excepted. © 2017 by EUROPEAN HOSPITAL Verlags GmbH. All rights reserved.
Editorial LABBOOK 2017 1 Dear reader, welcome to Labbook 2017, the fourth edition of our product and feature guide for medical laboratories in Europe. Our objective – to serve Europe – is not a particularly popular one these days. With our continent being in political distress, it is remarkable that the European Congress of Clinical Chemistry and Laboratory Medicine devotes an entire session to Europe-wide harmonisation. Even more important: the session does not only focus on technical or scientiic aspects but on the mutual recognition of professional training and certiicates in order to realize the crucial vision of free movement of labour across Europe. In the chapter on DNA we are tackling another contentious issue: gene editing. Professor Françoise Baylis, a Canadian bioethics expert, asks whether we can overcome our evolutionary limitations and whether we should be allowed to meddle with our genome. In addition to big politics and big ideas the new Labbook continues to offer the true and tried: a handy guide to relevant products available on the European market, compiled with the support of European and international manufacturers of analyzers, diagnostics, reagents, supplies and software. Browse the Labbook and let yourself be inspired. Different colours indicating the sections on the lab sub-disciplines help you navigate the wealth of information. As of late June you will also be able to access the products in our product data base at www.labbook.eu or as e-paper at www.healthcare-in-europe.com. The search function and links to the manufacturers’ websites take you straight to the relevant information. And if you need further details, please use the contact request form at www.healthcare-in-europe.com/en/global/contact.html. The manufacturers, the authors and the editorial team – we all look forward to receiving your feedback, be it praise, criticism or suggestions what you would like to ind in the next edition. Enjoy reading and browsing – and see you next year. Your Labbook team
Content Products & Systems Trends & Topics 1 Editorial 6 Seeking greater harmonisation – in laboratory medicine 10 Total Laboratory Automation (TLA) – DiaSys and Tosoh join forces 22 Sample Preparation Module – for LC-MS / MS 29 Coagulation analysers – A new generation is available 40 An image is worth a thousand words 43 Streck – Cell-Free DNA BCT CE 48 Should we tweak human evolution? 51 Clostridium dificile – Routine diagnostics in the medical laboratory 65 LabCentre – agility and accuracy for all laboratory disciplines 69 Companies & Suppliers 3 Automation & Sample Processing 11 Chemistry & Immunochemistry 36 Pathology 57 POCT 21 Mass Spectrometry 43 DNA 61 Information Technology 27 Hematology 53 Microbiology 66 Non-Diagnostic 2 LABBOOK 2017
Automation & Sample Processing Sample Processing Robotics Automation A u t o m a t e d S a m p l e P r o c e s s i n g
Sample Processing SAMPLE PROCESSING ASP Lab Automation – Bench-top Decapper Pluggo RH ASP Lab Automation – Tube Sorter SortPro Dimensions: Sample throughput: 360 × 560 × 610 mm (h × w × d) Over 2,000 tubes per hour Highlights: Pluggo RH decapper is a compact bench-top device that safely and eficiently removes original caps from blood specimen tubes. Dimensions: Sample throughput: 1,130 × 1,100 × 600 mm (h × w × d) for six sorting bins; + 200 mm for each two extra sorting bins Up to 2,000 tubes per hour Highlights: The SortPro tube sorter is an economical automation device for the pre-analytics of small and high-volume labs. · Avoids potential health risks from Carpel Tunnel Syndrome and aerosol contamination · Tubes are loaded and decapped in analyzer racks · Handles up to 15 racks each for input and output · Available for many analyzer rack types · Robust and simple design guarantees high reliability and uptime · Smaller models available that handle single racks · Early specimen identiication and registration · Fast presorting of specimens · Separates problematic specimens (missing requests, bad barcode, etc.) from routine work · Small and fast instrument, robust and reliable · Bulk input and bulk output of specimens · Freely conigurable number of sort bins · Processes all standard blood and urine tube types Beckman Coulter – AutoMate 1250 / 2550 SARSTEDT – Bulk Loader BL 1200 ID Aliquoter (1+1 aliqout): Weight: Dimensions: Highlights: 700 primaries with 10 % aliquoted to a daughter tube (AutoMate 1250) 900 primaries with 10 % aliquoted to a daughter tube (AutoMate 2550) 720 kg (AutoMate 1250 / 2550) 1,625 × 2,560 × 1,115 mm (without recapper) 1,625 × 2,560 × 1,415 mm (with recapper) (h × w × d) The AutoMate 1250 / 2550 family of pre- and post-ana- lytical sample processors and sorting systems boosts the possibilities of the laboratory automation system by providing a fully integrated sample bank solution for long-term archiving. The AutoMate 1250 / 2550’s archiving, retrieval for re-run, sample re-introduction and sample disposal allows for an easy worklow and sample management. Sample throughput: Up to 1,200 tubes / h Highlights: · Ideal in combination with any analytical platform · No sorting or handling required · Process any tube type of 80 to 110 mm length (with cap) and 11 to 16 mm diameter, including false bottom options · Suited for any sample type (serum / plasma, serum gel / plasma gel, EDTA, citrate, blood sugar, urine) · Integral ID module · Automatic sample accessioning · Customised sort rules to a variety of carrier types or bins · Safe, rapid and continous operation without error System range: · BL 1200 ID – Bulk to Rack · BL 2000 – Bulk to Bulk 4 LABBOOK 2017
SARSTEDT – Sorter DC/RC 900 Flex SARSTEDT – Decapper DC 1200 / Recapper RC 1200 Sample Processing Sample throughput: Up to 900 tubes / h Highlights: Pre- and post-analytics in one system: · Processes any tube diameter from 11 to 16 mm · Compatible with most racks or carrier types · Online or ofline operation · Opens tubes with push caps, stoppers and screw caps · Enables tube identiication by barcode reader and colour sensor · Can be customised to sort by tube type, material (colour) or test request · Closes tubes with archiving caps · Retroitting of decapping or recapping module is possible · Recapping with screw caps for SARSTEDT tubes with 13 or 15 mm diameter Highlights: Decapper DC 1200: · Automatic decapping of all tube diameters from 11 to 16 mm · Processes a variety of tube types in mixed operation · Sample pre-sorting for the decapping process is avoided Recapper RC 1200: · Automatic recapping of all tube diameters from 13 to 16 mm · Minimises the risk of exposure · Eliminates sample contamination · Archiving cap its all tubes from 13 to 16 mm diameter · Automated decapping enabled SARSTEDT – Sample Distribution System PVS 1625 Siemens Healthineers – VersaCell X3 Solution ROBOTICS Highlights: The PVS 1625 is a tailor made automation system for pre- and post-analytical processing of samples. It is capable to handle any kind of rack and tray type. As an open system, it is complementary to any analytical platform or can be used independently. Loading of unracked or racked sample tubes is via the Bulk Loader or in racks via the loading platform, which is suitable for closed and open tubes. Full function pre- and post-analytical system · Ideal in combination with any analytical platform · Modular coniguration according to customer needs with: Loading platform and / or Bulk Loader · ID Module – Decapper – Recapper · Aliquoter – Sorter · For all common tube types: 13 – 16 mm diameter, 65 – 100 mm length · Compatible with most racks or carrier types Dimensions: Sample throughput: Power consumption: Assays: 1,520 × 1,780 × 1,040 mm (h × w × d) Up to 200 samples tubes / h 800 W Menu varies based on analyzers connected Highlights: Advance worklow capabilities, streamline processes, and meet changing needs with agility – at a cost labs can justify. VersaCell X3 Solutions use robotics with dynamic STAT management to provide the optimal mix of chemistry and/or immunoassay analytics with one-touch sample management. Connect up to three Siemens’ instruments including ADVIA 1800 Chemistry System, ADVIA Centaur XPT and/or IMMULITE Im- mu-noassay Systems, and Dimension EXL and RxL Max Integrated Systems. *Product availability varies by country. LABBOOK 2017 5
Harmonisation Seeking greater harmonisation in laboratory medicine Unifying recognition of professional qualii cations I mproved harmonisation of laboratory medicine practice across Europe will help lead to better patient outcomes and produce comparable laboratory information irrespective of where and how the data have been generated, Mark Nicholls reports. With harmonisation regarded as a fundamental aspect of quality in laboratory medicine, it is high on the agenda of delegates to the EuroMedLab 2017 congress to be held between from 11 to 15 June at the Megaron Athens International Conference Centre, Greece. Harmonisation involves all the steps of the service (pre-analytical, analytical, and post-analytical phase) as well as embracing aspects of the profession in a symposium hosted by the European 6 LABBOOK 2017 Federation of Clinical Chemistry and Laboratory Medicine (EFLM). This will provide four lectures dealing with the harmonisation of the pre-analytical phase, medical laboratory accreditation, the mutual recognition of professional qualii cations across Europe, as well as continuous professional development. Speaking to European Hospital ahead of the conference, Gilbert Wieringa, Chair of EFLM’s Professional Committee, explained the importance of harmonising the recognition of professional qualii cations. ‘It’s to ensure that laboratory medicine is practised to common standards, so that patient safety is protected irrespec- tive of the country the specialist emanates from.
Harmonisation PROFILE: Gilbert Wieringa chairs the European Federation of Clinical Chemistry and Laboratory Medicine’s (EFLM) Professional Committee and is clinical lead for Laboratory Medicine in Bolton, England. Formerly the healthcare scientists programme lead in the Department of Health, and Greater Manchester Primary Care Trusts’ pathology lead, his main interests are in the provision of antenatal screening services, quality assurance for ‘high street’ diagnostics and the harmonisation of growth hormone measurements. ‘Under EU Directive 2013 / 55 / EU – the Recognition of Professional Qualii cations – harmonisation would extend opportunities for specialists to practice in other EU countries without having ‘compensation measures’ imposed on them such as the re-taking of local professional exams; in turn it could also catalyse a more equitable distribution of skills and resources across the EU.’ sation EC4 in setting standards for specialist practice, establishing the Register, an expected code of conduct, and adoption of the unifying term ‘Specialist in Laboratory Medicine’. He will offer guidance on how to join the Register, as well as share an update on progress with implementation of the Recognition Directive at the EU Commission. Dr Wieringa will highlight how EU Directive 2013 / 55 / EU provides a passport to professional migration across EU borders for professions that can work to a Common Training Framework. He will also point to EFLM holding a ‘Register of Specialists in Laboratory Medicine’; how the organisation is pursuing recognition as a unique cohort amongst laboratory medicine practitioners, and how achieving recognition raises the proi le of the contribution of laboratory medicine to better health and best care. Formed in 2007 through the merger of the Forum of European Societies of Clinical Chemistry (FESCC) and the European Com- munities Confederation of Clinical Chemistry (EC4), the EFLM connects national societes of clinical chemistry and laboratory medicine to create a platform for all European specialists in laboratory medicine. A strong advocate of the Register of Specialists, in adding weight to the argument for their recognition, in his talk Wieringa also intends to describe the backbone work that was already carried out by EFLM and its predecessor organi- While medical staff already enjoys professional migration as members of the sectoral professions, the Directive offers equal opportunity to science and pharmacy trained specialists, once a Common Training Framework has been adopted by one third of the EU member states (i. e. 10). It remains unclear how long the harmonisation process will take, though EFLM is maintaining close contact with its leads at the EU Commission throughout. The session will also hear from Wim Huisman, previously Head of the Laboratory for Clinical Chemistry and Haematology at the Medical Centre Haaglanden in Leidschendam; Ana-Maria Simundic, Professor in the Department of Medical Biochemistry at Zagreb University, and Elizabeta Topic, Professor of Medical Biochemistry at the Faculty of Pharmacy and Biochemistry University of Zagreb. * The EuroMedLab 2017 ELFM symposium ‘Harmonisation in laboratory medicine’: 10.30 a.m. – 2.30 p.m., 12 June. Venue: Skalkotas Hall, Megaron Athens International Conference Centre, Greece. Directive 2013/55/EU will boost professional migration across EU borders, leading to more even distribution of skill and resources. LABBOOK 2017 7
Automation AUTOMATION Beckman Coulter – Power Express Dynamic inlet: Centrifuges: Decapper: Aliquoter (1:1): 1,200 tubes / h 300 tubes / h (1), 600 tubes / h (2), 900 tubes / h (3), 1,200 tubes / h (4) 1,200 tubes / h 600 tubes / h Highlights: Power Express is a high-throughput automated sample handling system that can process chemistry, immunochemistry, hematology and coagulation tubes. A four-lane track and intelligent sample handling helps reduce turnaround time (TAT), reduce errors and improve lab productivity. Power Express performs industry leading centrifugation, with the option for up to four centrifuges to match the capacity of the automation line at 1,200 tubes per hour, decapping / recapping, aliquoting, with refrigerated as well as ambient storage, inished with a specimen automated disposal unit, giving labs the ability to deliver rapid and dependable TATs to clinicians, thereby reducing errors and improving overall laboratory eficiency and productivity. Beckman Coulter – AU680i Highlights: The AU680i offers laborattories the ability to combine an AU680 chemistry analyzer with a DxI immunoassay analyzer to form an entry-level automated workcell, streamlining laboratory worklow. The AU680i delivers high-capacity specimen processing power and lexibility to meet clinical laboratory workload challenges. Designed to help enhance eficiency, reduce costs and speed the delivery of test results, the AU680i features: · Parallel processing of shared chemistry · Single point of loading and unloading for and immunoassay specimens shared chemistry and immunoassay samples for rapid processing · Integrated decapper to minimize biohazard exposure risk and repetitive motion injuries INPECO SA – Total Laboratory Automation (TLA) Highlights: FlexLab is an open automation system capable of managing the complete process of a patient sample. From loading patient samples to their time depen- dent disposal, Flexlab’s dedicated pre analytical and post analytical modules (for identiication, sorting, centrifugation, decapping, aliquoting, recapping, storage, disposing and retrieval) as well as having direct connections to all of the most common analyzers of any specialty. Flexlab is completely scalable adapting to your laboratory current and future needs. Last but not least, FlexLab includes an integrated middleware solution, called Data Management Software, that receives patient results from analyzers connected either directly to automation or off-track, and sends those results back to the Lab Information Systems. 8 LABBOOK 2017
Automation Highlights: Aptio Automation combines intelligent techno- logies with Siemens worklow expertise in adaptable, multidisciplinary track designs with intelligent routing, single-sample low and point- in-space sampling. Choose from a selection of pre- and post-analytical processing modules and automation-ready chemistry, immunoassay, hematology, hemostasis and specialty testing analyzers. Our experts perform data-driven simulations, optimization modeling and more to design and monitor your solution for ongoing productivity. Mindray – CAL 8000 New Generation Cellular Analysis Line Highlights: · More compact in size than the irst generation · New track, higher eficiency and higher throughput · More lexible layout options to optimize use of laboratory space · Upgraded labXpert software to simplify data analysis · Automatic “Repeat”, “Rerun” and “Relex” in case of abnormal results Siemens Healthineers – Aptio Automation Snibe – Biolumi 8000 Highlights: Sample processing module · Loading 280 samples at one time · Continuous loading and unloading samples during operation · Speciic STAT channel Biochemistry module (B) · 1,600 tests / hour · Clot detection,liquid level detection · Wavelength range 340 – 800 nm, detect 16 different wavelengths simultaneously Electrolyte module (E) · 1,000 tests / hour · Clot detection,liquid level detection Immunoassay module (I) · 280 tests / hour · Clot detection,liquid level detection LABBOOK 2017 9
Automation Total Laboratory Automation (TLA) DiaSys and Tosoh join forces to offer a fast, precise and sensitive high-quality solution for clinical laboratory testing T osoh and DiaSys announce a collaboration for clinical labora- tory testing with the combination of Tosoh’s new generation analyzers (AIA-CL1200 for immunoassay and G11 for HbA1c) and DiaSys’ BioMajesty JCA-BM6010 / C. Instruments are linked through Evoline and Evoline Manager, Tosoh’s open laboratory automation and middleware solution. The collaboration addresses current requirements regarding clinical testing. DiaSys BioMajesty JCA-BM6010 / C The BioMajesty JCA-BM6010 / C is designed to increase the per- formance of medium-sized laboratories. It is also the ideal system for speciality laboratories. The throughput of up to 1,200 tests / hour, 43 reagent and 84 sample positions are a guarantee for lexibility in everyday use. It handles a full menu of photometric and immunoturbidimetric assays as well as Na, K, Cl determina- tions by indirect ISE methods. Special emphasis was put on the software to combine highest user-friendliness with optimally secured results. A special feature is the integrated on-board hemolysis function for optimized HbA1c determination. Dynamic range extension avoids additional dilutions and a dedicated STAT port allows for immediate STAT processing. Clot detection and liquid level sensor technology ensure conidence in results. The analyzer works with very small sample volumes, making it the perfect instrument in pediatric and geriatric settings. The BioMajesty JCA-BM6010 / C is the system with the smallest footprint in its class hence saving precious laboratory space. DiaSys supplies ready-to-use reagents well known for their excellent on-board stability with the instrument. The result in conjunction with extremely low reagent consumption is cost eficiency of the highest order. CONTACT DiaSys Diangostic Systems GmbH Alte Straße 9 · 65558 Holzheim / Germany phone: + 49 (0)64 32 91 46-0 systems@diasys.de · www.diasys-diagnostics.com 10 LABBOOK 2017 TLA solution in Czech Republic: Input- output-module, decapper, two decapper, two BioMajesty, one Tosoh AIA2000 BioMajesty connected with Tosoh AIA-CL1200 and HPLC G11 at MedLab Dubai 2017 Open Lab Automation The integration of a Tosoh and DiaSys analyzer into the auto- mation implementation of a clinical laboratory offers signiicant beneits to the working processes and is intended to achieve the following goals: · · Integration of multi-competence technologies Improvement of laboratory turnaround time with consistent throughput over time · Simultaneous management of routine and emergency workloads · Automation of repetitive manual procedures · Elimination of the need for pre-sorting specimens · Qualiication of operators’ work, taking them off tasks associated with pre-analysis · Simple connection and a sophisticated data transmission system ensure analytical quality with minimal maintenance
Chemistry & Immunochemistry Clinical Chemistry Immunochemistry Immunoassays Integrated Systems Mass Spectrometry Electrophoresis/ Chromatography Plasma Protein Testing Infectious Disease Testing Drug Testing Urine Screening Research Use Only
Chemistry & Immunochemistry CLINICAL CHEMISTRY Beckman Coulter – AU5800 Series Biomed – Cystatin C Turbidimetric Assay Dimensions: Weight: Sample throughput: Power consumption: 1,260 × 2,600 × 1,580 mm (h × w × d) 1,070 kg 2,000 – 9,800 / h 200 – 240 W Highlights: The AU5800 series represents the highest throughput and fastest chemistry analyzers in the AU family. With true random-access capabilities and a throughput ranging from approximately 2,000 tests up to 9,800 tests per hour, the AU5800 is available in four different scalable models, positioned for the high-volume core hospital laboratory to the ultra-high volume commercial laboratory market segments. Highlights: · Cystatin C for screening and monitoring of impaired kidney function · Measurement Range: 0,1 – 10 mg / L · Cystatin C-Calibrator (IRMM ERM-DA471 / IFCC) · Our turbidimetric Cystatin C latex test is a ready- to-use assay that can be run on all clinical chemical analyzers. · Cystatin C is found to be more sensitive to actual changes in GFR in the early stages of chronic kidney disease than creatinine based GFR estimates in the so-called creatinine blind GFR. DiaSys Diagnostic Systems – BioMajesty JCA-BM6010/C No of channels: Assays: Sample throughput: Dimensions: Weight: 43 55 1,200 samples / h 1,220 × 1,108 × 850 mm (h × w × d) 450 kg Integrated solution management for your laboratory Highlights: dr. neumann kindler & www.labcore.de 12 LABBOOK 2017 BioMajesty JCA-BM6010 / C is designed to increase the performance of medium-sized laboratories. Throughput of up to 1.200 tests / hour, 43 reagent and 84 sample positions guarantee lexibility in everyday use. It handles a full menu of clinical chemistry assays as well as Na, K, Cl determination by indirect ISE. The possibility to connect the device to a sample conveyor system offers a complete automation solution and the consolidation of clinical chemistry with immunology and coagulation testing.
Chemistry & Immunochemistry DiaSys Diagnostic Systems – respons910 Diatron – Intelligent Walk Away Chemistry with P500 No of channels: Assays: Sample throughput: Dimensions: Weight: 30 62 135 samples / h 600 × 600 × 670 mm (h × w × d) 60 kg Highlights: respons910 is a fully-automated bench top analyzer for maximum eficiency. High on-board capacity of 30 methods and 30 sample positions combined with a throughput of 135 tests / h offers the lexibility for everyday use. A STAT port allows loading of emergency samples at any time. High-quality clinical chemistry and immunoturbidimetric tests from DiaSys round off the respons910 system. Onboard hemolysis and whole blood sample type introduction make respons910 dedicated for HbA1c testing. Sample throughput: Dimensions: Weight 300 tests / h, 480 with ISE 900 × 660 × 620 mm (h × w × d) 115 kg Highlights: · Bench top, fully automated Clinical Chemistry system · Advanced Windows-based software · Uninterrupted worklow, enhanced walk-away operation and remote access diagnostics · Full range of barcoded reagents, controls and calibrators Reliable Infection Diagnostics Haematological Staining Solutions Complete Solutions for the Clinical Chemistry: Latex Enhanced Reagents, Control Sera, Calibrators Short Distances. Fast Decisions. www.biomed.de A Good Choice for 40 Years
Chemistry & Immunochemistry CLINICAL CHEMISTRY Genrui – Auto Chemistry Analyzer GS480 Mindray – BS-480 Clinical Chemistry Analyzer Sample throughput : Dimensions: Weight: 400 tests / h 1,100 × 1,120 × 810 mm (w × h × d) 210 kg Highlights: · Fully automated system with random access and STAT · 24-hour refrigerated reagent compartment · 9-step wash station with alkaline cleaning and hot water · 105 sample positions and 90 reagent positions · Grating optical system with 13 wavelengths (340 – 850 nm) · Liquid level detection, collision protection and depth auto-adjustment · Pre- and post-dilution and rerun for sample · Intuitive software with simple operation · Flexible connection with LIS Highlights: · Discrete, random access, fully automated · Constant throughput with 400 photometric test per hour, up to 240 tests per hour for ISE · 24-hour on board refrigerated reagent compartment at 2~10° C · Reusable cuvettes with auto-washing station · Two independent mixing stirrers · Clot detection, automatic probe cleaning, liquid level detection & collision protection (vertical & horizontal) · Reversed grating system with 12 wavelengths (340~800nm) · Pre-dilution and post-dilution for sample · Built-in bar code scanner · Bi-directional LIS interface Mindray – BS-240 Chemistry Analyzer Mindray – SAL 6000 Modular System Highlights: · One of the smallest 200 T / H throughput automated chemistry analyzers · Up to 80 sample and 80 reagent positions · Automatic hemolysate preparation for HbA1c test · A minimum of 100 μL reaction volume Highlights: · Seamless integration of chemistry and immunology tests, worklow optimization · Uniform software interface, easy for operation · One tube sampling, lexible to test · Enhanced ALP+AMPPD CLIA technology · Flexible scalability, on-site upgrading · Comprehensive test menu 14 LABBOOK 2017
Chemistry & Immunochemistry Sentinel – SENTiFIT270 (Sysmex) Siemens Healthineers – ADVIA Chemistry Systems Sample throughput: Dimensions: Weight: Assays: Up to 270 samples / h 625 × 870 × 670 mm (h × w × d) 120 kg Fecal Immunochemical Test* *Calprotectin* will be launched in July 2017 Sample throughput: Highlights: The SENTiFIT270 is a fully automated clinical-chemical system. It has been specially developed to measure the SENTiFIT pierceTube for quantitative determination of occult faecal haemoglobin. Highlights: · Continuous reloading of the racks during measurement · Cooling the reagents for permanent storage in SENTiFIT 270 · Measure up to 1,250 tests without changing the reagent · Automatic warning of deviation of the luid level · Integrated sensor prevents blocking of the sample needle · Barcode reader for reagents Up to 2,400 tests / h with ADVIA Chemistry XPT System Up to 1,800 tests / h with ADVIA 1800 Clinical Chemistry System The ADVIA Chemistry XPT System is engineered for simple, continuous operation and provides fast, accurate results and predictable TAT through VeriSmart Technology and onboard aliquoting. Microvolume technology enables a high onboard test capacity of over 100,000 photometric tests for long walkaway times, especially valuable when running on Siemens Aptio Automation. *Product availability varies by country. DiaSys Diagnostic Systems · Clinical chemistry · Immunoturbidimetric tests · Automated analyzers for every need · Point-of-care products Quality Diagnostics. Made in Germany. www.diasys-diagnostics.com
Chemistry & Immunochemistry IMMUNOCHEMISTRY Beckman Coulter – Access AccuTnI+3 Troponin I Assay Beckman Coulter – Anti-Mullerian Hormone (AMH) Highlights: The Access AccuTnI+3 Troponin I assay delivers the precision, clinical sensitivity and clinical speciicity necessary to assist physicians with the diagnosis of myocardial infarction (MI). Access AccuTnI+3 Troponin I in the core lab gets physicians the critical results they need and can cut triage time in half. The assay can use two serial samples collected within a 3-hour period, rather than waiting for a six-hour period, to provide a more accurate diagnoses. A large multicenter prospec- tive clinical trial on the AccuTnI+3 assay conirmed that the assay provides the clinical performance needed for proper patient management. Highlights: The measurement of circulating anti-Mullerian hormone (AMH) has been applied to a wide range of clinical applications. The Access AMH assay features convenient transition to automated testing through consistent and standardized results with Beckman Coulter’s AMH Gen II assay improve support of fertility assessment through increased sensitivity and precision at the low end of the analytical measuring range. Today, its use is mainly based on its ability to relect the number of antral and pre-antral follicles present in the ovaries (the ovarian reserve). Beckman Coulter – phi (Prostate Health Index) Beckman Coulter – UniCel DxI 800 Access Immunoassay System Dimensions: Weight: Sample throughput: Assays: 1,700 × 1,710 × 970 mm (h × w × d) 630 kg Up to 400 tests / h > 50 preprogrammed, bar-coded immunoassay methods Highlights: The UniCel DxI 800 has exceptional throughput, proven chemiluminescent technology and assay protocols similar to other analyzers in the Beckman Coulter family – so you can simplify and automate your immunoassay testing. The UniCel DxI 800 immuno-assay system allows laboratories to decrease process steps and improve turnaround time – with ease of use. Highlights: phi (Prostate Health Index) is an index of three tests and combines the power of those tests into one answer or phi score. The Prostate Health Index is an aid in distinguishing prostate cancer from benign prostatic conditions, for prostate cancer detection in men aged 50 years and older with total PSA ≥ 4.0 to ≤ 10.0 ng / mL, and with digital rectal examination indings that are not suspicious for cancer. Prostatic biopsy is required for diagnosis of cancer. 16 LABBOOK 2017
Chemistry & Immunochemistry Beckman Coulter – Vitamin D Assay DRG Instruments – DRG:HYBRiD-XL Highlights: Access 25(OH) Vitamin D Total is a new assay that will expand the Access Bone Metabolism portfolio on the UniCel DxI and Access 2 systems. The assay is standard- ized to the NIST-Ghent ID-LC-MS / MS Reference Method Procedure (RMP) and provides excellent stability and reproducibility. Features include a unique, opaque reagent pack designed to prevent light-induced reagent degradation; convenient assessment of deicient populations through a broad dynamic range; and speed and lexibility through instrumentation options (available on Beckman Coulter’s Access 2 and DxI immuno assay platforms). Sample throughput: No of parallel samples: Assays: Dimensions: Weight: 40 tests per run 40 Immunoassay and Clinical Chemistry 586 × 608 × 635 mm (h × w × d) 52 kg Highlights: This unique technology allows the simultaneous measurement of immunoassays and clinical chemistry parameters in one sample: Free Testosterone, Calpro tectin, 17-OH Prog., Androstenedione, Renin, Aldosterone, 25-OH Vitamin D, Hepcidin-25, HbA1c, Cystatin C and others. Fujirebio – LUMIPULSE G1200 Fujirebio – LUMIPULSE G600II Sample throughput: Time to irst result: Sample capacity: Reagent capacity: Dimensions: 120 tests / h 30 min Up to 100 samples 504 tests on board 1,450 × 1,200 × 800 mm (h × w × d) Highlights: A compact, robust and reliable fully automated chemiluminescent enzyme immunoassay analyzer. The LUMIPULSE G1200 offers optimized reagent and consumables handling, true random access, and a con- stant throughput regardless of the assay format or combination. The unique mono test cartridge elimi- nates open reagent bottle stability concerns. It comes with the broad menu of routine and unique Lumipulse G biomarkers and is fully compatible with laboratory automation systems (LIS). Sample throughput: Time to irst result: Sample capacity: Reagent capacity: Dimensions: 60 tests / h 35 min Up to 36 samples (incl. 3 priority specimens) 112 tests on board 642 × 890 × 725 mm (h × w × d) Highlights: A fully automated benchtop chemiluminescent enzyme immunoassay analyzer. The LUMIPULSE G600II offers optimized reagent and consumables handling, true random access, and a constant throughput regardless of the assay format or combination. The unique mono test cartridge eliminates open reagent bottle stability concerns. It comes with the broad menu of routine and unique Lumipulse G biomarkers. LABBOOK 2017 17
Chemistry & Immunochemistry IMMUNOCHEMISTRY SARSTEDT – ELISA Plates / Micro test plates for immunoanalytics Siemens Healthineers – ADVIA Centaur XPT & CP Systems Highlights: One of the analyses most commonly used is the Enzyme-Linked Immunosorbent Assay (ELISA). With this method, even the smallest concentrations of a range of substances (proteins, peptides, antibodies, hormones etc.) can be detected and quantiied from complex solutions. Sample throughput: Up to 240 tests / h (XPT) Up to 180 tests / h (CP) Highlights: The ADVIA Centaur XPT Immunoassay System is engineered to provide timely, reliable results with continuous operation to meet the workloads of the most demanding laboratories. It is among the highest-throughput immunoassay systems available. The ADVIA Centaur CP Immunoassay System is a mid-volume, high-throughput bench top system. Both systems use advanced Acridinium Ester technology that can be tailored to meet different diagnostic needs. *Product availability varies by country. Siemens Healthineers – IMMULITE 2000 XPi System Mindray – CL-1200i Chemiluminescence Immunoassay System IMMUNOASSAYS Sample throughput: Up to 200 tests / h Highlights: The IMMULITE 2000 XPi Immunoassay System combines allergy and specialty testing with routine immunoassay testing. It features a wide-ranging menu, 90-day onboard reagent stability, and advanced software and hardware to handle the many testing challenges that labs face. The IMMULITE 2000 XPi system is a continuous, random access analyzer with proven reliability and easy-to-use software that allows laboratories to improve their testing capacity. *Product availability varies by country. 18 LABBOOK 2017 Highlights: · Up to 180 T / H, one of the fastest benchtop CLIA analyzers · Onboard capacity of 25 reagents and 60 samples · Non-stop reill of samples, reagents and consumables during testing · Swing arm and touch screen for easy operation
Chemistry & Immunochemistry Snibe – MAGLUMI 800 Snibe – MAGLUMI 1000 Sample throughput: Dimensions: 180 tests / h 1,020 × 720 × 560 mm (h × w × d) Sample throughput: Dimensions: 120 tests/hour 1,350 × 760 × 1,580 mm (h × w × d) Highlights: · On board capability: up to 40 samples · Reagent position: 9 · Refrigerated sample and reagent area · Clot detection · Liquid level detection · Auto dilution for high concentration sample · Color touch screen · Bi-communication with LIS via ASTM protocol Highlights: · On board capability: up to 144 samples · Reagent position: 15 · Refrigerated reagent area · Clot detection · Liquid level detection · Auto dilution for high concentration sample · Color touch screen · Bi-communication with LIS via ASTM protocol Snibe – MAGLUMI 2000 Snibe – MAGLUMI 2000 Plus Sample throughput: Dimensions: 180 tests / h 1,350 × 760 × 1,580 mm (h × w × d) Sample throughput : Dimensions: 180 tests / h 1,440 × 760 × 1,520 mm (h × w × d) Highlights: · On board capability: up to 144 samples · Reagent position: 15 · Refrigerated reagent area · Clot detection · Liquid level detection · Auto dilution for high concentration sample · Color touch screen · Bi-communication with LIS via ASTM protocol Highlights: · On board capability: up to 144 samples · Reagent position: 25 · Refrigerated sample and reagent area · Clot detection · Liquid level detection · Auto dilution for high concentration sample · Color touch screen · Bi-communication with LIS via ASTM protocol LABBOOK 2017 19
Chemistry & Immunochemistry IMMUNOASSAYS Snibe – MAGLUMI 4000 Plus Wako – µTASWako i30 Dimensions: Weight: Sample throughput: Assays: 520 × 550 × 600 mm (w × h × d) 71 kg 25 tests / h AFP / AFP-L3, DCP Sample throughput: Dimensions: 280 tests / h 1,380 × 890 × 1,600 mm (h × w × d) Highlights: Highlights: · On board capability: up to 144 samples · Reagent position: 25 · Refrigerated sample and reagent area · Clot detection · Liquid level detection · Auto dilution for high concentration sample · Color touch screen · Bi-communication with LIS via ASTM protocol INTEGRATED SYSTEMS · Electrokinetic Analyte Transport Assay (EATA) · High sensitive luorescence detection · Assay precision less than 3% CV for AFP-L3 · Increased sensitivity of liver cancer (HCC) detection by combined use of AFP, AFP-L3 and DCP · Unique system to calculate the GALAD score (Gender, Age, AFP-L3, AFP, DCP) for outstanding p erformance regarding early HCC recognition · Improved chance of detecting HCC early during surveillance of patients at risk Siemens Healthineers – Dimension EXL Chemistry Systems Siemens Healthineers – Dimension Vista Intelligent Lab Systems Sample throughput: Up to 440 photometric chemistry tests / h and 187 electrolyte tests / h Up to 167 heterogeneous immunoassay tests / h Sample throughput: Up to 2,000 tests / h (Dimension Vista 1500) Up to 1,000 tests / h (Dimension Vista 500) Highlights: Siemens Healthineers was the irst company to integrate chemistry and immunoassay testing in one instrument, simultaneously processing tests from one sample tube to improve worklow eficiency. The Dimension EXL integrated system includes our patented LOCI homogeneous chemiluminescent technology, offering fast immunoassay reactions with high sensitivity and low sample volumes. *Product availability varies by country. Highlights: Dimension Vista Systems integrate photometry, nephelometry, V-LYTE electrolyte detection, and LOCI homogenous chemiluminescence technologies in one smart workstation. Labs can simultaneously process tests for multiple disease states on a single platform from a single tube. The sample-centric design found on the Dimension Vista System incorporates lean princi- ples for simpliied and consolidated sample processing. *Product availability varies by country. 20 LABBOOK 2017
Chemistry & Immunochemistry MASS SPECTROMETRY Bruker Daltonics – Toxtyper Sciex – 4500MD series: Triple Quad or QTRAP LC-MS/MS Dimensions: Weight: Sample throughput: Power consumption: No of channels: Assays: No of parallel samples: 790 × 590 × 790 mm (w × h × d) 130 kg Up to 60 samples / h 2.2 kW 1 Vitamin D and Immonusuppressant drugs 0 Highlights: Simplicity, Speed and conidence: First Time, Every Time most demanding clinical applications Highlights: · Enable your clinical laboratory to develop tests for the · Rapid Forensic Screening · High-conidence drug identiications · Comprehensive coverage · Toxicology research · Unprecedented easy-to use For research use only. Not for use in diagnostic procedures. · Keep assays in-house and increase lab capabilities with an affordable benchtop platform with unique perfor- mance and application versatility · Minimize downtime, improve lab productivity with robust performance and excellent ROI · Quantitate multiple low level compounds in a single analysis with high accuracy and sensitivity · Minimize training time and increase eficiency with powerful worklow-driven software Shimadzu – LCMS-8045 CL Shimadzu – LCMS-8050 CL Dimensions: Weight: Highlights: 1,180 × 540 × 610 mm (w × d × h) 140 kg The LCMS-8045 offers the proven high sensitivity, high speed and robustness of Shimadzu’s UFMS series to provide highly reliable data for applications that demand the sensitivity and speed of a mass spectro- meter, such as for simultaneous analysis used in the clinical research ield. Due to the heated-ESI probe and UFsweeper II collision cell, it offers the highest sensitivity in the middle-range class (UFsensitivity). Dimensions: Assays: Highlights: 1,180 × 540 × 610 mm (w × d × h) 140 kg Triple Quadrupole Mass Spectrometry is the method of choice for quantiication of trace-level analytes in complex samples for a variety of applications including clinical research, forensic, toxicology, pharmacokinetics. Combined with our world-leading UHPLC systems, and maintaining Shimadzu’s proprietary ultrafast technologies (UFMS), which include high-speed MRM transitions, MS / MS acquisition, and ultra-high speed polarity switching, the LCMS-8050 can dramatically improve analytical throughput. LABBOOK 2017 21
Chemistry & Immunochemistry Highly lexible automated Sample Preparation Module for LC-MS / MS W hile IA’s (Immunoassay) has been the most used technic for clinical analysis, the shift to LC-MS / MS is constantly increasing for several type of analysis like immunosuppressant, vitamin D or steroids panel, but also for several new assays including anti-coagulants, anti biotics, plasma renin activity, etc. The change from Immunoassay to LC-MS / MS could have been faster if sample preparation was not a limiting factor among others: it is nowadays the bottleneck in the complete process using LC-MS / MS analysis. Thanks to Shimadzu’s UFMS (Ultra-Fast Mass Spectrometry) technologies including ultra-fast polarity switching (5 ms), short pause time (1 ms), multi MRM (555 / s), and fast scanning possibilities (30,000 uma / s), combined to the well-known robustness of Shimadzu systems, LC-MS / MS has proven to be a powerful tool for clinical analysis and the cost per analysis was decreased signiicantly. for people dealing with sample preparation, has been solved by the introduction of the fully automated sample preparation system CLAM-2000 (Clinical Laboratory Auto mation Module). Based on many years of experience from SHIMADZU in producing clinical analyzers, the system automatizes the pre-treatment of blood or other biological samples before LC-MS / MS analysis. The CLAM-2000 (RUO) is designed for customers that handle biologics samples and that are seeking to introduce the use of LC-MS / MS in their analytical worklow to contribute to sample prep automation. Its graphical user interface with a touch panel screen greatly simpliies the use of the analytical system even by non-skilled user in mass spectrom- etry. It is also a tool for customers dealing with issues of variability in analytical results or infection risk. The bottleneck of sample preparation which is often tedious, subject to risk of errors, and is also increasing the risk of contamination Shimadzu has released this new and unique fully automated sample preparation module (RUO), connected online to LC-MS / MS all over Europe. 22 LABBOOK 2017
The system is widely opened and allows the use, either of home- brew methods or commercial reagent’s kits, enabling the manual preparation steps to be adapted into the system. Available pretreatment processes include: · dispensing samples · dispensing reagents · stirring · suction iltration incubation · · automatic transfer of sample vials to auto-sampler after pre-treatment NB: all these steps can be freely selected for the process The direct detection of analytes in blood, urine or any other biological samples, the measurement of trace concentration of drugs, and any other applications detection has been improved thanks to Mass Spectrometry: Using CLAM-2000 in front of your LC-MS / MS system, you will improve your sample preparation process and therefore your quality data. By simply placing blood collection tubes in the system, the CLAM-2000 performs all other processes through to LC-MS / MS analysis automatically. Unlike standard dispensing systems/robots, that are based on batch processing 96-well plates, the CLAM-2000 is completely automatic from pre-treatment to analysis and processes individual samples successively in parallel. Consequently, it results in uniform pre-treatment times between samples, without slowing processing speed, and improves data reproducibility and accuracy. Chemistry & Immunochemistry In addition, to keep a maximum degree of lexibility and to adapt to future needs, the CLAM-2000 is compatible with the full range of Shimadzu’s LC-MS / MS: · LCMS-8040 · LCMS-8045 · LCMS-8050 · LCMS-8060 Since its launch, the CLAM-2000 has demonstrated its capabilities for various type of analysis: Immunosuppressants · · Vitamin D2 / D3 · Steroids panel · Anticoagulants · Antibiotics · Antiepileptics · Neuroleptics · Benzodiazepines · Micophenolic acid · Antidepressants Consequently, the CLAM-2000 is the irst and unique system in the world able to perform all steps fully automated from pre-treatment of the sample to LC-MS / MS analysis for a large panel of compounds, requiring only the simple task of placing the blood, or biological luids collection tubes, reagents, internal standards and specialized pre-treatment vials in the system. It also features excellent management functions that can provide a dramatically improved worklow with better safety for clinical research and higher reproducibility. This product is intended for research use only (RUO). Not for use in diagnostic, therapeutic, and medication procedure. LABBOOK 2017 23
Chemistry & Immunochemistry MASS SPECTROMETRY Shimadzu – LCMS-8060 CL ELECTROPHORESIS / CHROMATOGRAPHY biostep – Chemiluminescence / Fluorescence Imager Celvin S Dimensions: Assays: Highlights: 1,180 × 540 × 610 mm (w × d × h) 140 kg The LCMS-8060 delivers the highest sensitivity and fastest analysis speed of any LCMS on the market today. A newly developed UF-Qarray boosts ion intensity but suppresses noise. By improving the ion sampling device, the ion guide, and vacuum eficiency, Shimadzu has achieved an unprecedented sensitivity in quantitative analysis by LC / MS / MS while keeping high robustness for daily analysis. Dimensions: Weight: 420 × 240 × 360 mm (h × w × d) 10 kg Highlights: · Smallest chemiluminescence imaging system, imaging area up to 14 × 14 cm · Cooled CCD-camera · Binning up to 6 × 6 · Four camera options from high resolution to high sensitivity · Electromagnetic safety lock · Acquisition of colorimetrically-stained markers possible · GxP-compliant in Master and Serial Mode · Image export as raw data for analysis or as optimized image for publication · NEW: Fluorescence module incl. four excitation and emission wavelength settings each · Already available from 9,950 € Shimadzu – HPLC / UHPLC PLASMA PROTEIN TESTING Siemens Healthineers – BN II System Weight: Sample throughput: Analyzer: 150 kg (330 lbs.) Effective: Approx. 130 tests / h depending on the assay mix; Nominal: 225 tests / h More than 60 programmed assay protocols for specialty plasma protein testing Assays: Highlights: Highlights: SHIMADZU is offering a wide range of solutions in liquid chromatography starting from standard HPLC systems to high end UHPLC systems including compact con- igurations. Available with several options for columns switching, pre-concentration, online SPE, etc, the systems are also well recognized for coupling with highly sensitive detectors like luorescence, radio-activity, electrochemical, or mass spectrometry. To increase throughput with mass spectrometers, SHIMADZU offers the NEXERA-MX coniguration. 24 LABBOOK 2017 The BN II System is a fully automated protein analyzer that features high lexibility, continuous loading, and excellent instrument reliability. · Optimal alignment of reagents and systems for more eficient determination of proteins · Bar code identiication of primary sample tubes, standards, controls, and reagents · Comprehensive menu of over 64 assays for routine and specialty testing, including innovative assays such as CDT, FLC and BTP · Average effective throughput of 130 tests / h
Chemistry & Immunochemistry Siemens Healthineers – BN ProSpec System Siemens Healthineers – Quadriga BeFree System INFECTIOUS DISEASE TESTING Weight: Sample throughput: Assays: Highlights: Analyzer: 115.2 kg (254 lbs.) Effective: Approx. 65 tests / h depending on the assay mix; Nominal: 100 tests / h More than 60 programmed assay protocols for specialty plasma protein testing The BN ProSpec System is a dedicated, compact platform that offers a consolidated menu of specialty and routine reagents for reliable plasma protein testing. · Proven nephelometric technology and minimized sample preparation for increased conidence in results · Broad menu of over 64 assay protocols, including innovative markers such as CDT, FLC, and BTP · Average effective throughput of 65 tests / hour Weight: Sample throughput: 3 conigurations: ~730 kg ~970 kg ~1,210 kg 3 conigurations: 1 : 1 Up to 700 results per run in <4 hours; 1 : 2 Up to 2,464 results per run in ~7.5 hours; 1 : 3 Up to 3,000 results per run in ~8 hours Highlights: The Quadriga BeFree System delivers the next generation in ELISA automation in a dedicated, fully automated blood screening analyzer. · Full blood screening menu, including Enzygnost Anti-HCV 4.0 and Enzygnost HIV Integral 4 Assays · Primary tubes, sample processor, and robotic transport system for operator safety · Ability to connect up to three BEP III Systems for different volume needs · Up to 3,000 results in an 8-hour shift for maximized walkaway operation DRUG TESTING URINE SCREENING Siemens Healthineers – Viva-ProE System Beckman Coulter – Iris iRICELL Series Weight: Sample throughput: Approx. 93 kg / 205 lbs (excl. monitor arm and panel PC) Up to 133 EMIT tests per hour with two reagents; Up to 65 EMIT tests per hour with three reagents Highlights: A lexible, new approach to dedicated drug-testing analysis, the Viva-ProE System provides greater ease of use, workstation eficiency, and a full drug-testing menu, all in one powerful benchtop system that is supported by unrivaled Syva experts. The system offers peltier cooling for eficient reagent use, can run up to 133 Emit tests per hour and 12 Emit assays simultaneously; 120 tests can be programmed with 10 open test channels. Results available within 10 minutes of processing. Sample throughput: Up to 70 samples / h (microscopy), Up to 210 samples / h (chemistry) Highlights: The Iris iRICELL2000, available from Beckman Coulter, integrates urine chemistry and microscopy into a fully automated walk-away solution to help increase eficiency and improve lab productivity. By focusing on one particle at a time, IRIS products isolate, identify and characterize particles, nearly eliminating the need for manual microscopic review. This leads to improved worklow, lower review rates and reduced urine cultures. LABBOOK 2017 25
Chemistry & Immunochemistry URINE SCREENING Sysmex – UN-Series Sysmex – UC-3500 Sample throughput: Dimensions: Weight: Max. 276 samples / h 829 × 638 × 709 mm (h × w × d) 75 kg Dimensions: Weight: 872 × 1,918 × 901 mm (h × w × d) 269 kg Highlights: Highlights: · Combines digital imaging, particle and chemistry analysis (UD-10 / UF-5000 / UC-3500) · Fully automated urinalysis worklow solution · User-friendly and easy handling · Multiply your throughput by connecting more than one UF together with one or more UD-10 · Extend your possibilities by adding a UC-3500 · Intelligent data management by U-WAM · User friendly and easy handling · Fully automated urine chemistry analysis · Fast total turnaround time (TAT) · Combination with the UF-5000 and the UD-10 for an optimal, fully automated urinalysis worklow · 11 test strip parameters including microalbumin and creatinine, and ive system parameters · Able to distinguish between RBC and haemoglobin thanks to the new CMOS sensor · High accuracy for speciic gravity (Urinalysis Work Area Information Management System) (refractometry measurement method) and cloudiness Sysmex – UF-5000 RESEARCH USE ONLY (RUO) Shimadzu – CLAM-2000 Sample throughput: Dimensions: Weight: 105 (urine), 20 (body luids) samples / h 855 × 760 × 754 mm (h × w × d) 90 kg Highlights: · Fully automated urine particle analysis · Modular concept: easy to combine with other members of the UN-Series for a fully automated urinalysis worklow Dimensions: Weight: Assays: Highlights: · Integrated body luid mode · Small sample volume needed · Exclude negative UTI samples in less than a minute · Blue laser for better detection of bacteria · New depolarised side scatter light to differentiate RBC and crystals · Differentiation of epithelial cells & casts · Reliable QC management by our SCNS network 670 × 700 × 1,190 mm (w × d × h) 185 kg Immunosuppressants, vitamin D, steroids CLAM-2000 provides users seamless integration of automated sample preparation with LC-MS / MS to improve data quality, sample throughput, laboratory eficiency and safety Simple worklows allow users to go from blood collection tubes to results without any additional sample handling. Each sample is processed successively in parallel, to optimize instrument usage. Easy to access software for management of reagents, calibration curves, control samples and maintenance ensure reliability and quality of results. 26 LABBOOK 2017
Hematology BLOOD CELL COUNTER Beckman Coulter – UniCel DxH Connected Workcell Solution Diatron – Complete Blood Count Versatility with the Aquila Dimensions: Weight: Sample throughput: 1,905 × 3,225 × 787 mm (h × w × d) 1,016.6 kg 300 samples and 140 slides / h Highlights: With the new UniCel DxH Series of connected hema- tology workcells, your lab can streamline worklow through smart workload balancing advanced analytics – providing relevant and thoughtful worklow eficiency while delivering accurate patient results. The UniCel DxH eliminates the need for pre-sort and offers worklow enhancements with bi-directional transport. Sample throughput: Parameters: Dimensions: Weight: 60 tests / h 22 323 x 272 x 366 mm (h × w × d) ~16 kg inc reagent pack Highlights: · Compact size and unique on-board reagent pack requires little storage and work space · Three part diff hematology results requiring around 20 μl of blood · Closed or open tube mode · Portable with an optional battery pack Genrui – 5-Part Auto Hematology Analyzer KT-6610 HORIBA Medical – Yumizen H2500 and Yumizen H1500 Sample throughput: Dimensions: Weight: 60 samples / h 430 × 350 × 435 mm (w × h x d) 28 kg Highlights: · Tri-angle laser scattering and sheath low for WBC Samples throughput: Dimensions: Weight: Power consumption: 120 tests / h 840 × 730 × 650 mm (w × h × d) 112 kg 100 v / 50 hz to 240 v / 60 hz differentiation and counting · Impedance for RBC and PLT counting · No extra PC required, 10.4-inch touch screen · Built-in barcode scanner, built-in thermal printer · Sample volume: 20ul for whole blood mode, 20 μl for prediluted mode · Three reagents for test, two lyses are placed in the analyzer · One-click solution for basic trouble shooting · Ideal to be your irst 5-Part hematology analyzer Highlights: HORIBA Medical has developed two new hematology systems combining both innovative and recognized technologies: the Yumizen H1500 and the Yumizen H2500. With a genuine throughput of 120 tests per hour for CBC-DIFF & NRBC including differential and nucleated RBCs, the Yumizen H2500 and Yumizen H1500 are able to absorb the worklow of laboratories with high activity. This solution includes our newest middleware, the Yumizen P8000, which allows laboratories to centralize data management. 28 LABBOOK 2017
Hematology A new generation Coagulation analysers is available system. The company TECO have generated the possibility to link the instrument via bluetooth to a smart-device (tablet or mobile) to create a direct connection to the TECO Cloud (servers). With this technical option, the instrument service status can be directly transmitted to the cloud. Any mail function can get an immediate response or feed-back. The continuous automatic traceability of used reagents (lot and expiry) and the important certiied consumables can be activated, too. Quick response on daily routines Another helpful built-in feature is the internal barcode reader for the scan of individual patient-identiication on the primary tube before each measurement and combine it with the result. If the instrument is connected to LIS or TECAM Software, the patient-ID and the result will be directly transmitted to the LIS (Laboratory Information System). The Barcode reader could also read in reagent ID (Lot and Expiry) and consumable ID for veriication and release. The details make the difference The remarkable details in every single component is archieved by selecting of premium suppliers. The performance of a high level instrument is strongly depending on the concept in general and the perfect usability to reach the requirements of a modern laboratory analyser. Priority No. 1 was the get a daily routine reliability and easy-to-use operation. Software and connection possibilities With the Coatron X product family starts a new time line in analy- sis management and service maintenance. Operation via intuitive, colored touchscreen, as well patient result management are perfectly optimized. Coatron X Highlights · Highest optical resolution, enlarged optic range, smallest sample and reagent volume 0,1 mOD – 3500 mOD, just with 75 μL sample and reagent volume · Complete optical analysis. No further parts required, like balls, stirrers etc. · Adaptation of the light level. Automatic light level adjustment of · the optic channels to each sample Exclusion of disturbance. Stray light reduction, exact tempera- ture control, all parameter are preset LABBOOK 2017 29 Successful realization and new deinition in the manual / semi-automatic coagulation analytic. T he Company TECO Medical Instruments + Trading GmbH, Germany is working since 25 years intensive in development, production and sales of coagulation analysers, which are distributed and supported through the worldwide distributors into hospitals and Coagulation laboratories. For a new generation of manual or semi-automatic coagulation analysers COATRON X it was important for TECO GmbH, to fulil all the requirements from a Coagulation Laboratory with modern „State-of-Art“-Technology. The concept of the new instrument line based on one construction with new electronic, touch-display etc. and nearly identical user software, but with three different versions, one, two or four channel optic, as well selected sample and reagent positions. As result, we come out with a Coatron X Eco, Coatron X Pro und Coatron X Top. The Innovation is the goal! During development, it was very important to get a high level on precision and accuracy in founding and calculating of the clot detection (measurement) and as well to fulil intended use. To get reliable and reproduce able results, it was necessary to have a high-level knowledge in Coagulation diagnostic and mathematical calculation for the interpretation of possible and variables clotting curves. An additional feature was a high sensitive detection optic CONTACT TECO Medical Instruments Dieselstraße 1 · 84088 Neufahrn, Germany phone: +49 (0)87 73 707 80-0 info@teco-gmbh.com · www.teco-medical.com
Hematology BLOOD CELL COUNTER Mindray – BC-5150 Auto Hematology Analyzer Mindray – BC-5390 Auto Hematology Analyzer Dimensions: Weight: Sample throughput: Assays: 410 × 320 × 400 mm (h × w × d) 24 kg 60 samples / h 25 basic parameters + 4 research parameters, 3 histograms for WBC, RBC and PLT + 3 scattergrams for WBC differential Highlights: · Impedance method for RBC and PLT counting · Cyanide free reagent for hemoglobin test · Flow Cytometry (FCM) + Triangle laser scatter + chemical dye method for WBC 5-part differential analysis and WBC counting · Sample volumes are prediluted modes 20 μl, whole blood mode 15 μl, capillary whole blood mode 15 μl · Data Storage if possible up to 40,000 results including numeric and graphical information Highlights: · Semi-conductor laser combined with chemical dye method and low cytometry · 31 parameters with complete 5-part differentiation (CBC+DIFF) on white blood cells · 40-tubes autoloader with random access · Closed tube for STAT samples · Only 33 μl sample volume for CBC + DIFF results · Up to 60 tests per hour · FDA approved · Supports whole blood mode for capillary sample · Supports bi-directional LIS connection Siemens Healthineers – ADVIA 360, 560, and 560 AL Systems Siemens Healthineers – ADVIA 2120i System Dimensions: Sample throughput: Parameters: 360 × 316 × 492 mm (h × w × d) 520 × 410 × 490 mm (h × w × d) Approx. 60 tests / h 22 – 26 parameters;* 3- or 5-part white cell differential Dimensions: Sample throughput: Parameters: 860 × 1,410 × 680 mm (h × w × d) Up to 120 samples / h CBC incl. NRBC, 6-part white cell differential, reticulocytes, body luids, and comprehen- sive morphology results Highlights: The ADVIA 360, 560, and 560 AL Systems provide laboratories with intuitive, easy-to-use, and scalable hematology solutions designed to offer the right it for every lab. Each system delivers fast, reliable, and accurate CBC and white cell differential testing with the performance and adaptability that low- and mid-volume labs need. The optional autoloader on the ADVIA 560 AL streamlines automatic sampling for even greater worklow eficiency. *Not all parameters are available in the U.S. Highlights: Siemens’ high-volume hematology analyzer, the ADVIA 2120i System with Autoslide streamlines worklow by eliminating the majority of manual steps commonly performed to maximize productivity. Its unique testing methodology optimizes results while offering the simplicity and lexibility you need for easy integration into your lab. With connectivity to Aptio Automation and CentraLink Data Management System, it supports accurate, fast, sample processing with fully customizable, user-deined features. 30 LABBOOK 2017
Sysmex – XN-1500 (Count. Smear. Stain. All-in-one haematology) Sysmex – XN-L Series Hematology CBC + DIFF up to 70 samples / h with the optional Speed-up licence 440 × 510 × 450 × 460 – 660 mm (h × w × d) (depending on model) 35 (XN-350, XN-450); 53 (XN-550 incl. sampler); 3 (XN-550 monitor) · XN-350: Single sample analysis in open mode · XN-450: Single sample analysis in closed or open mode · XN-550: Automated sampler analysis for increased worklow productivity: Rerun & Relex and continuous loading · Add reticulocyte and body luid analysis as you need them · XN quality. Cost-effective. Plus full support. · Delivering specialist solutions for labs that need to offer niche diagnostics. · A perfect secondary analyser · Upgrade from 3-part diff to 5-part diff at a price you can afford Sample throughput: Dimensions: Weight: Highlights: Sample throughput: XN-module CBC+DIFF: up to 100 slides / h, Dimensions: Weight: Highlights: up to 40 slides / h in BF mode SP-50 module SP-50: up to 30 slides / h in S mode, up to 75 slides / h in H mode 1,006 × 1,053 × 855 mm (w × h × d) 211 kg · Fully integrated slide maker & stainer SP-50 · Flexible throughput depending on the workload · Automatic Relex measurement in case of unreliable results · Reduced time for the preparation of the slides · Minimum need for manual tasks and less biohazard procedures · Small footprint · Optional integration of digital imaging module DI-60 · Reduced sample volume (for the smear preparation) · Staining protocols (SP-50): May Grünwald – Giemsa, Wright – Giemsa, Wright Coatron Complete NEW range of Coagulation Analysis with the highest standard and reliability - Coatron X Complete optical analysis No further parts required, like balls, stirrers etc. Adaptation of the light level Automatic light level adjustment of the optic channels to each sample Exclusion of disturbance Stray light reduction, exact temperature control, all parameter are preset MADE IN GERMANY Downloads/Information: www.teco-medical.com/coatron-x
Hematology INTEGRATED HEMATOLOGY Beckman Coulter – HematoFlow Sysmex – XN-3100 DI Sample throughput: CBC+DIFF: up to 200 slides / h, up to 40 slides / h in BF mode per module Dimensions: Weight: Highlights: SP-50: up to 30 slides / h in S mode, up to 75 slides / h in H mode 2,000 × 1,150 × 1,630 mm (w × d × h) 1,020 kg · Fully integrated slide maker & stainer · Choose Advanced Clinical Parameters as needed · Flexible throughput · Automatic relex measurement · Integrated backup concept · Digital Imaging (DI) module: – Seamless integrated morphology analysis of slides – Eficient, detailed review and validation for greater accuracy – Faster, improved worklow – Long-term storage and archiving of cell images – Consistency in analysis quality Highlights: HematoFlow is a unique cellular analysis solution which brings automated low cytometry testing into the rou-tine, mid to large haematology laboratory. When used in the HematoFlow solution with automated gating software, CytoDiff, a 5 colour, 6 monoclonal antibody reagent cocktail, yields more extensive results with a 16-part low differential. With the HematoFlow, labs save time by reducing manual slide reviews. Sysmex – XN-9100 Sorting & Archiving FLOW CYTOMETRY Streck – Cyto-Chex BCT Sample throughput: CBC+DIFF: from 200 slides / h, from 40 slides / h in BF mode per module Dimensions: Weight: depending on coniguration depending on coniguration Highlights: · Scalable and modular haematology automation line · Flexible coniguration of XN analysis modules and rack entry and exit positions · Discrete rack management · Built-in auto relex · Uninhibited worklow from routine to specialised testing · Automatic relex measurement in case of unreliable results · Choose Advanced Clinical Parameters as needed · Optional pre-sorting, sorting and achieving module for discrete rack management with TS-10 Dimensions: 13 x 75 mm, 4.0 ml draw 10.25 x 64 mm, 2.0 ml draw Highlights: · A blood collection tube for the preser vation of whole blood specimens for immunophe- notyping by low cytometry · The preservative maintains the integrity of the white blood cell cluster of differen- tiation (CD) markers at room temperature for convenient transport and storage · Preserves peripheral blood samples’ quali- tative and quantitative leukocyte subset characteristics and is FDA 510(k) cleared for consistent recovery of HIV associated lymphocyte · Optional integration of ESR and HbA1C analysis · Available in 4.0 ml or 2.0 ml sizes 32 LABBOOK 2017
HISTOLOGY EQUIPMENT Biomed – Hemaix Dyeing Solution MEDITE – Rotary Microtome M530, semi-automatic Hematology Highlights: · Hemaix quick-staining for hematology and cytology · Standardized ready-to-use staining solutions · Reproducible and consistent staining quality · Short dyeing time – only 30 seconds to two minutes · No iltration or sedimentation of unsolved colour particles · Complete standardization with the Hemomat-K 6 stainer · Clean and eficient way of working Highlights: This highly precise, semi-automatic Rotary Microtome M530 brings safe and easy sectioning to the laboratory. With a Memory Positioning option and user-oriented technology, it offers high performance and great lexi- bility. Clearly arranged controls and a smooth running handwheel create a comfortable user experience. The Microtome M530 is ergonomically designed and made in Germany by seasoned experts. It is part of a new generation of MEDITE Microtomes, setting a new GOLD STANDARD. COAGULATION Siemens Healthineers – Sysmex CA-600 Systems Siemens Healthineers – Sysmex CS-5100 System Dimensions: Sample throughput: Weight: Approx. 490 × 566 × 490 mm (h × w × d) Approx. 60 PT tests / h Approx. 43 kg Highlights: The Sysmex CA-600 Systems – with the smallest foot- print in their class – are built on a history of proven reliability and provide scalable options for routine and specialty* coagulation testing. · Features clotting, chromogenic,* and immunologic* measurements with true random access · Enables critical tests to be processed at any time via STAT sample processing · Offers the most frequently requested routine and specialty tests, including INNOVANCE D-Dimer* *Sysmex CA-660 System only. Dimensions: Sample throughput Weight: Approx. 1,280 × 1,576 × 1,150 mm (h × w × d) Approx. 400 simultaneous PT/APTT tests / h Approx. 362 kg Highlights: The Sysmex CS-5100 System – now available in the U.S. – offers high-volume and multisite labs smartly designed PSI technology and automation connectivity for streamlined worklow and high-quality test results on the irst run. Simultaneous, multiwavelength PSI technology helps labs to identify and manage unsuitable test specimens prior to analysis. The Sysmex CS-5100 System offers an expansive test menu of routine and specialty hemostasis assays (including several INNOVANCE assays). LABBOOK 2017 33
Hematology COAGULATION Siemens Healthineers – Sysmex CS-2500 System Sysmex – CS-1600 Dimensions: Sample throughput Weight: Approx. 685 × 1,113 × 895 mm (h × w × d) Approx. 180 simultaneous PT / APTT tests / h Approx. 140 kg Highlights: The Sysmex CS-2500 System– now available globally including the U.S. – offers mid-volume and multisite hemostasis labs smartly designed technologies for improved eficiency, exceptional accuracy, and reliable irst-run results. Equipped with next-generation PSI technologies, the system takes hemostasis testing to the next level. The Sysmex CS-2500 System offers an expansive test menu of routine and specialty hemostasis assays (including several INNOVANCE assays), all on a single instrument. Sample throughput: Dimensions: Weight: Assays: Up to 120 tests / h (PT) 540 × 760 × 690 mm (h × w × d) Approx. 85 kg 20 simultaneously Highlights: · Minimal need for hands-on maintenance · Perfect solution for medium-size labs with needs for specialty testing · Proven, reliable technical performance with advanced CS-technology · High-quality results based on advanced multi-wave- length technology · Traceability for operation history and results Sysmex – CS-2400/2500 TECO – Coatron A6 Plus Sample throughput: Dimensions: Weight: Assays: Up to 180 tests / h (PT) 685 × 775 × 895 mm (h × w × d) Approx. 110 kg 60 simultaneously Highlights: · Advanced inhibitor testing with cross-mixing tests · CS-2400: open tube model, CS-2500: cap-piercing model · Rule-based rerun & relex testing · Gold standard in “light transmission aggregometry” · Automated, high-accuracy platelet function testing by aggregometry · High-quality results based on advanced multi-wave- length technology Dimensions: Power Consumption: Number Of Channels: Weight: 500 × 950 × 800 mm (w × h × d) 90 – 240 Vac, 50 – 60 Hz 6 52 kg Highlights: · Fully automated 6-channel Hemostasis Analyser for routine Coagulation tests · Clotting, chromogenic, immunological · Quarter test volume (75 µL) · High speed testing · Biphasic waveform analysis · Inclusive multifunctional, reliable Management · Pre-analytic sample checks for interferences and Software over-/underilling · Consolidates routine and specialised testing in a single analysis system · Preset for nine different proiles · PT, APTT, TT, FIB, all major Standard Coagulation tests · AT, PC special chromogenic Coagulation tests 34 LABBOOK 2017
TECO – Coatron X TECO – Hemostasis reagents Hematology Dimensions: Power Consumption: Number Of Channels: 230 × 140 × 90 mm (w × h × d) 110 – 240 Vac, 50 – 60 Hz / 5 Vdc, 3.3 A 1 – 4 Highlights: · Highest optical resolution, enlarged optic range, small- est sample and reagent volume 0,1 mOD – 3,500 mOD, just with 75 μL sample and reagent volume · Complete optical analysis · No further parts required, like balls, stirrers etc. · Adaptation of the light level · Automatic light level adjustment of the optic channels to each sample · Exclusion of disturbance · Stray light reduction, exact temperature control, all parameter are preset Highlights: A complete range of Hemostasis reagents for routine and for differentiated coagulation analysis (chromogenic and immun-turbidimetric tests). Our reagents comply with our high quality standards. Prothrombin Time (PT), Activated Partial Thromboplastin Time (aPTT), Fibrinogen (FIB), Thrombin Time (TT), Protein S (PS), Lupus Anticoagulant (LA), Factor V Leiden (PCA), Chromogenic Tests (AT), Protein C (PC), D-Dimer, Dimex D-Dimer, Red D-Dimer, Blue D-Dimer, Deicient Plasma, Reference Plasma, Control Plasma
MALDI-MSI Bruker Daltonics – rapileX MALDI Tissuetyper Doc-db IS AN INNOVATIVE SOLUTION FOR YOUR QM DOCUMENTATION: , Automatically controls the creation process of the documents create » review » approve , Publishes the documents print, PDF, e-mail , Maintains the archive and version history , Supports user interaction by task lists , Supports quality managers with highly sophisticated tools: Process designer Process monitor Report interface Scheduler Highlights: · Mass Spectrometry Imaging based on MALDI-TOF · Direct imaging of proteins, peptides and lipids · Available as TOF / TOF · Unique ion source for robust day-to-day operation · Fast acquisition speed of up to 50 true square pixel / second · Laser repetition rate up to 10 kHz · Pixel size <10 µm · Comprehensive software For research use only. Not for use in diagnostic procedures. SCANNER Hamamatsu Photonics – NanoZoomer S360 Highlights: · Real high throughput: Greatly improved throughput (more than 80 slides / h at 40 × mode for 15 × 15 mm sample sizes) and slide capacity of 360 for high work- load laboratories. · Hassle free: Simple operation and hassle free scanning. New, powerful scan software for fast and easy operation · Error free: Robust and stable scanning. Automatic system calibration. · Blur free: Sharp focus on entire specimen. Dynamic Pre-Focusing (DPF) method and advanced focus scoring with automated rescan option for higher success rate. www.docdb.de LABBOOK 2017 37
Pathology SCANNER Hamamatsu Photonics – NanoZoomer S210 Hamamatsu Photonics – NanoZoomer S60 Highlights: With over a decade of experience in digital pathology, Hamamatsu introduces the NanoZoomer S210. Highlights: Features: · 210 slide scanning capability · Batch scanning or continuous loading of slides · High performance · Cost-effective · Simple operation · New sleek design and small footprint NanoZoomer S60: The most lexible slide scanner for any histology lab – The best of Hamamatsu’s know-how, combining lexibility and outstanding image quality. Features: · High-speed and sensitivity in luorescence · Best image quality both in brightield and luorescence · Double-size slides scan · Ideal for all research and pathology laboratories MICROSCOPY Olympus – CX43 Olympus – UC90 4K Microscopy Highlights: · Ergonomic Design · Ideal for versatile application · Long lifetime LED illumination Highlights: · Up to 4K UHD image capturing · One Camera for Multiple Applications · 9-megapixel CCD camera The CX43 microscope enable users to remain comfort- able during long periods of microscopy observations. The microscope frame conforms to the user’s hands and the location of the control knobs maximize ergonomics to improve work eficiency. Users can quickly set a specimen with one hand, while adjusting the focus and operating the stage with the other hand with minimal movement. The microscope features an optional camera port. The 9-megapixel UC90 camera captures it all: brightieldimages of superior quality, and up to 4K UHD imaging. Whatever your imaging needs are, expect no less than exceptional results in image quality, sensitivity, dynamic range, and color idelity. The UC90 offers luid sample navigation and focusing, making it effortless and convenient to locate regions of interest right on your screen. Excellent microscope imaging has never been as easy and versatile as with the UC90. 38 LABBOOK 2017
SLIDE PREPARATION KUGEL medical – Formalin Mixing and Dispensing Station AFMDS-100 MEDITE – Rotary Microtome M530, semi-automatic Pathology Dimensions: Weight: Power consumption: 600 × 1,320 × 700 mm (w × h × d) 120 kg 250 W / 230 Volt / 10 Amp / 50-60 Hz Highlights: · Contact-free delution of concentrated formaldeyhde with variable quantities of water and a buffer solution · Integrated microprocessor allows you to safe and Highlights: recall your settings · Control through one single surface with LCD display · Transfer to multiple remote work stations for dispensing · Is to be connected to the water supply · No more tiresome dragging of heavy formaldehyde tanks · No direct contact with concentrated formaldehyde and subsequent reduction of formaldehyde contamination in pathologies This highly precise, semi-automatic Rotary Microtome M530 brings safe and easy sectioning to the laboratory. With a Memory Positioning option and user-oriented technology, it offers high performance and great lexi- bility. Clearly arranged controls and a smooth running handwheel create a comfortable user experience. The Microtome M530 is ergonomically designed and made in Germany by seasoned experts. It is part of a new generation of MEDITE Microtomes, setting a new GOLD STANDARD. PRINTER Primera Technology – Signature Cassette Printer Primera Technology – Signature Slide Printer Highlights: Primera’s Signature Cassette Printer is designed for use in pathology and histology labs to print high-resolution text, graphics and bar codes directly onto tissue cassettes helping to reduce the risk of misidentiication of specimens. It is available in both a stand-alone manual printer and a fully automated complete system. · On-demand or batch mode printing · Black or colour printing · Cost reduction by inventorying only white cassettes · Chemical-resistant ink – ensures reliable identiication of cassettes · USB interface – ability to integrate with LIS · Two years warranty (After product registration within six months) Highlights: Primera’s Signature Slide Printer can signiicantly increase the eficiency of labs while helping to reduce the risk of misidentiication of specimens. · On-demand, full-colour printing – prints only the number of slides needed · Prints directly onto slides – eliminates handwriting that is hard to read and labels that are hard to apply · Cost reduction by inventorying only white-frosted slides · Xylene-, alcohol-, heat- and chemical-resistant ink – ensures reliable identiication of slides · PTSlide Software allows connection to LIS systems · Compact design · Two years warranty (After product registration within six months) LABBOOK 2017 39
Pathology A laser was used to ablate cells in a zebrai sh brain, and the microscope then recorded the microglia (green) moving to the site of injury (arrow) to clear up debris. Credit: Francesca Peri / EMBL An image is worth a thousand words Light microscopy today offers a wealth of techniques that provide fascinating insights into life on subcellular level.
Pathology “In light microscopy these days there are so many new techniques that each of us can only handle a subset of them,” says Christian Tischer, scientifi c offi cer in der Advanced Light Microscopy Facility of the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, and adds that “in light microscopy, just as in electron microscopy, every few years a new techno logy emerges.” The expert presented some of these techniques during a fi eld trip of the European Union of Science Journalists’ Associations (EUSJA) to EMBL, where these techniques have become indispensable in basic research. Take for example superresolution micro scopy which makes use of the specifi c physical features of fl uorescent dyes to achieve resolution far below 200 nm, half the wavelength of light, and long believed to be an unsurmountable resolution limit. This discovery, which was awarded the Nobel Prize, allows the visualisation of the molecular structure of the nuclear pore, a protein complex in the membrane surrounding the cell nucleus that allows the transport of certain molecules in and out of the nucleus. Superresolution fl uorescent microscopy can show the exact structure of the nuclear pores on the level of the individual proteins. Another fascinating technology is laser based nanosurgery where cells are sliced with a nanolaser scalpel. At EMBL, this technique was used to examine the biophysical features of the cytoskeleton. It turned out that this ‘cell skeleton’, unlike a human one, cannot simply be cut in two. “These structures might be called skeletons but they are very differ ent from ours,” Tischer points out. In another experiment the researchers tried to fi nd out how socalled microglia – immune defense cells that identify and eliminate damaged and dead neurons – recognize their prey. The researchers used a nanolaser scalpel to cut the tendrils with which the cells grab and pull the neurons. Light sheet microscopy is another technique that provides insight on the cellular level. Based on the socalled triangulation slice images of an object can be acquired and fused into a 3D image – or rather a 3D movie of live cells to be precise. One of the movies shows the fusion of an egg cell and a sperm cell and the subsequent fi rst cell division of the new embryo. Light sheet microscopy is used here primarily because these cells are highly light sensitive and thus would not survive conventional light microscopy. “It can be really boring to sit at the micro scope and look for something specifi c,” Tischer concedes. Therefore methods are being developed to automate the search. In automated feedback microscopy the soft ware learns to detect and photograph inter esting targets in a sample. This technique for example found the abovementioned nuclei prior to mitosis. It is moreover an important tool in the Tara Oceans Project where over a period of three years the team aboard the French research schooner Tara collected water samples from all oceans on the globe. These were examined at EMBL for plankton – with sensational results: No less than 150,000 plankton species were discovered where previously the number of plankton species was estimated to be around 11,000. “For a human lab team this would have been a task for a lifetime,” Tischer laughs. PROFILE: Christian Tischer, PhD, studied physics in Heidelberg and received his doctorate from the European Molecular Biology Laboratory (EMBL), also in Heidelberg. Following post-doc work in bio- physics in Amsterdam, he is currently at EMBL’s Advanced Light Microscopy Facility where he supports scientists with microscopy and image analysis. Nuclear pores images in a super- resolution microscope. This technology enabled scientists to understand how different components of the nuclear pore are arranged. Credit: A. Szymborska & J.Ellenberg / EMBL LABBOOK 2017 41
Pathology INFORMATION TECHNOLOGY Hamamatsu Photonics – NDP.serve3 Image Server Software Visiopharm – ONCOTOPIX Highlights: NDP.serve3 is the next generation of our established image server software. It is a power solution to share and manage whole slide images (WSI) across a network, either as a stand-alone solution or integrated with your LIS/LIMS software. Key Beneits / Features: · Secure database with enhanced security functionality · Intuitive, simple to use graphical user interface · Easy to share whole slide images · Seamless integration with NDP.view2 – the fastest Mac and Windows WSI viewer on the market Highlights: ONCOTOPIX Scan · Proven performance · Fast high quality slide scanner ONCOTOPIX Dx · Validated Dignostic Decision Support · Automated Worklows ONCOTOPIX Discovery · Dedicated tools for cancer research Scanners produced by Hamamatsu Book a demo and opt in to win a Powerbank at http://bit.ly/2qVregp Visiopharm – ONCOTOPIX Quantitative Image Analysis Visiopharm – QUALITOPIX ONCOTOPIX Quantitative Image Analysis Highlights: Leading IA solution for cancer diagnostics providing: · Unprecedented high-precision alignment · Automated tumor cell detection · Enabling Multiplexing and co-localization analysis · For protein and ISH test results as well as H&E · Revealing information about Tumor Micro Environment Book a demo and opt in to win a Powerbank at http://bit.ly/2qVregp * Validated for in vitro diagnostic use (CE-IVD) in Europe in combination with the CE-IVD APPs from Visiopharm 42 LABBOOK 2017 Highlights: Novel & patented technology for monitoring staining performance in between EQA evaluations Coming Soon: A novel tool to measure and document your daily or weekly laboratory performance and ensure performance variations are kept at a minimum. Book a demo and opt in to win a Powerbank at http://bit.ly/2qVregp
WORLD FORUM Pathology FOR MEDICINE LABMED FORUM The Intefdisciplinafy Fascination dcfeening tests: Can you diagnose cancef ffom blood? Thfombosis pfophylaxis Iithout labofatofy tests: HoI ceftain afe the neI anticoagulants? NeI tissue ffom stem cells: Is this the futufe of thefapy fof diabetes and heaft attacks? Wave of fefugees in Gefmany: Is thefe noI a thfeat of neI infections? Current issues from medicine and research will be discussed at the MEDICA LABMED FORUM in Düsseldorf from 13 to 16 Novembef 2017. Under the guiding principle “The Intefdisciplinafy Fascination”, laboratory medicine, molecular pathology, microbiology, medical technology and life sciences present themselves as innovation drivers, which will provide new impulses for all areas of medicine. Doctors and patients, health policymakers and healthcare providers, media representatives and all other visitors of the “world’s largest medical trade fair” are invited to four exciting theme days with top-class lectures and podium discussions. The events take place each day from 11 a.m. to 4 p.m. and are free of charge for trade fair visitors. The conference language is English. Fouf theme days Monday, 13 November: Cancef diseases Tuesday, 14 November: Cafdiovasculaf diseases Wednesday, 15 November: Innovative diabetes diagnostics Thursday, 16 November: Infection and migfation Fufthef infofmation Messe Düsseldorf GmbH, Project Management MEDICA E-mail: GiesenH@messe-duesseldorf.de Trillium GmbH Medizinischer Fachverlag E-mail: georg.hoffmann@trillium.de 13 –16 NOVEMBER 2017 DÜSSELDORF GERMANY www.medica.de Every year in November, the World Forum for Medicine, with approximately 5,000 exhibitors, is an outstanding meeting point for experts from all across the world. In addition to a compre- hensive trade exhibition, an ambitious supporting programme also awaits you in Düsseldorf. Here, innovative solutions for medical laboratories as well as a versatile range of laboratory and diagnostics technology will be presented to you. At MEDICA, you fi nd the entire spectrum of medicine for your very specifi c thematic areas. BE PART OF THE NO.1! LABBOOK 2017 43
DNA Streck headquarters in Omaha, USA The Cell-Free DNA BCT CE tube S cientists have discovered that dying tumor cells release small pieces of their DNA into the bloodstream. These pieces are called circulating tumor DNA (ctDNA) or circulating cell-free DNA (ccfDNA). The detection of cancer causing mutations in this ctDNA has emerged as a promising approach for non-invasive oncology testing and is being called a “liquid biopsy”. However, white blood cell lysis and subsequent release of genomic DNA into these liquid biopsy samples mask the rare ctDNA and require that cumbersome pre-analytical steps be taken to ensure reliable and accurate test results. Liquid biopsy samples must withstand stressors of pre-analytical variables such as storage, transportation, extraction and sample preparation. Streck offers a solution to prevent many of these pre-analytical variables from effecting valuable patient samples and skewing assay results. Streck‘s Cell-Free DNA BCT CE is a blood collection device that is well documented to prevent the release of genomic DNA into plasma by stabilizing white blood cells, allowing convenient collection, storage, and transport of patient samples. CONTACT Streck 7002 S 109th St · 68128 Omaha, USA phone: +1 402 333 1982 international@streck.com · www.streck.com 44 LABBOOK 2017 Streck‘s Cell-Free DNA BCT CE provide: · A direct draw blood collection tube with a stabilizing reagent that preserves the separation of the cell-free and cellular DNA fractions · Cell-Free DNA stability of 14-days at room temperature, CTC stability of 7-days at room temperature · Easy sample collection at hospitals and medical practitioner’s ofices · Room temperature shipping to the testing lab · Ensures consistency of patient material and reliability of test results Cell-Free DNA BCT CE is the trusted global leader in cell-free DNA sample stability.
DNA Ampliication Integrated Systems Ampliication / Detection Clinical Chemistry Extraction Liquid Biopsy Service Research Use Only
DNA AMPLIFICATION BIORON Diagnostics – RealLine Pathogen Diagnostic Kits Orion Diagnostica Oy – Orion GenRead Highlights: RealLine Pathogen Diagnostic Kits from BIORON Diagnostics – with outstanding features: · Lyophilized mastermixes · One handling procedure for all kits – simple & fast · Same PCR cycling conditions · Controls included · Multiplexing kits For a wide range of parameters: · STIs: CT, NG, Mycoplasma ssp., Ureaplasma ssp., Gardnerella, Trichomonas · TORCH: Toxoplasma and Rubella · Herpes-viruses: CMV, HSV-1 and -2, EBV, VZV · Tick-borne infections: Borrelia and TBEV (FSME) · HPV: kits for HR and LR Human Papilloma Virus types Assays: C dificile, campylobacter Highlights: Orion GenRead system is a small benchtop system for molecular pathogen detection, based on proprietary technology SIBA (Strand Invasion Based Ampliication). · Flexibility with 1 – 12 samples in one run · Fast test results are available in less than one hour · Ready to use kits contain all needed reagents · Bi-directional HIS / LIS connectivity · Portable and robust instrument suitable for various laboratory settings · CE marked test kits for C dificile and campylobacter. Next: RSV and Inluenza A&B SARSTEDT – White Multiply PCR Plates Biomed – GenomEra CDX Instrument INTEGRATED SYSTEMS Dimensions: Weight: Sample Throughput: Assays: No of parallel samples: 540 × 325 × 393 mm (w × h × d) 32.7 kg 4 samples / h MRSA, C. dificile, Norovirus, GBS, S. pneumoniae 4 Highlights: · CE-certiied, innovative PCR tests for pathogen detection · Menu of tests: MRSA, C. dificile, Norovirus, Group B Streptococci, S. pneumoniae · Direct Screening validated for multiple sampling sites · Diagnosis from culture plate and blood culture · Automatic result interpretation · Reliable measurement on the compact GenomEra CDX platform in 50 – 70 minutes Highlights: · White wells for improved luorescence relection · Thin-walled reaction tubes for quick temperature transfer · Free from DNA, DNase, RNase and PCR inhibitors · Barcode labeling on plates with half or full skirt is available on request 46 LABBOOK 2017
AMPLIFICATION / DETECTION Agena Bioscience – MassARRAY Dx Analyzer 4 Agena Bioscience – MassARRAY Colon Panel DNA Technology: Benchtop MALDI-TOF mass spectrometry to identify somatic mutations using single base extension with mass distinction of extended primers (using iPLEX chemistry and SpectroCHIP Array) Time to results (from DNA): <8 hours, incl. 1 h of hands-on-time Capacity: Two 96-well SpectroCHIP Arrays per run; up to 5 runs / day (up to 200 samples per day) Automated software output: Mass spectra, mutant and wild-type calls, report for each patient sample Target: >200 clinically actionable somatic mutations in four principal oncogenes (KRAS, BRAF NRAS, PIK3CA) # of multiplexed PCR reactions: 8 Sample amount: 40ng DNA per sample Sample throughput: Up to 10 patient samples and 2 controls per plate Sensitivity: Detection and analysis of mutation frequencies as low as 5 % Highlights: The MassARRAY Dx is a CE-IVD marked genetic analysis system for the reliable multiplexed analysis of up to hundreds of clinically relevant mutations in a single worklow. Powered by sensitive and accurate mass-based detection, it maximizes laboratory resources (sample-to- answer testing with minimal hands-on time in a single eight-hour work shift) and clinically actionable mutation reports. At present, two panels for colon and lung cancer enable cost-effective and accurate mutation screening. Highlights: MassARRAY Dx Colon Panel is a CE-IVD approved set of clinically validated assays for cost-effective, accurate mutation screening to help you rapidly proile actionable somatic mutations in KRAS, BRAF, NRAS, and PIK3CA genes. The kit includes the required controls (wild-type and negative). The Panel is based upon clinical practice guidelines for diagnosis, treatment and follow-up for metastatic colorectal cancer recommended by ESMO. Agena Bioscience – MassARRAY Dx Lung Panel Agena Bioscience – MassARRAY Dx Nanodispenser RS 1000 CLINICAL CHEMISTRY Target: >300 somatic mutations in 10 principal genes (EGFR, KRAS, BRAF, PIK3CA, NRAS, ALK, ERBB2, DDR2, MAP2K1, and RET) # of multiplexed PCR reactions: 8 Sample amount: 40ng DNA per sample Throughput: Up to 10 patient samples and 2 controls per plate Sensitivity: Detection and analysis of mutation frequencies as low as 5 % Purpose: Processing time: Rapid sample transfer to Agena’s SpectroCHIP arrays for further processing in MassARRAY Dx Analyzer 4 < 15 minutes / 96-well microtiter plate Highlights: The MassARRAY Dx Lung Panel is a CE-IVD approved set of clinically validated assays for cost-effective, accurate mutation screening to help you rapidly proile actionable somatic mutations in ALK, BRAF, DDR2, EGFR, ERBB2, KRAS, MAP2K1, NRAS, PIK3CA, and RET genes. The Panel kit includes the required controls (wild-type and negative). It is based upon clinical practice guidelines for diagnosis, treatment and follow-up for metastatic non- small-cell lung cancer (NSCLC) recommended by ESMO. Highlights: The MassARRAY Dx Nanodispenser RS 1000 is a bench- top dispensing instrument employing advanced robotics for the rapid transfer of nanoliter sample volumes onto SpectroCHIP Arrays. Standard coniguration is two microtiter plates at a time (can also be done with a single plate). Samples are trans-ferred from the microtiter plate to the SpectroCHIP in less than 15 minutes. The spotted SpectroCHIP Arrays are then loaded into the MassARRAY DxAnalyzer 4. LABBOOK 2017 47
DNA Should we tweak human evolution? Bioethical discussions expose powerful opinions A ccording to Darwin, humans will one day become extinct. Some don’t think we need to accept this fate because gene editing may allow us to use our brains to take over the evolutionary story. ‘Why, if we believe in evolution and the risk that one day humans will become extinct, should we not use our brains to take over our own evolutionary story,’ philosopher Françoise Baylis will ask on 13 June, during her plenary session talk on ‘Human gene editing: The dawn, the zenith, and the dusk’ at the Clinical Chemistry and Laboratory Medicine annual congress, being held in Athens, Greece. Professor Baylis, Chair in Bioethics and Philosophy at Dalhousie University in Halifax, Canada, and an acknowledged authority on the ethical issues of manipulating the human genome, was a member of the organising committee for the irst-ever International Summit on Human Gene Editing. As she recently wrote, since its discovery the gene-editing system known as clustered regularly interspaced short palindromic repeats (CRISPR) has been used by scientists to make precise alterations in the DNA sequence of living cells. This offers the prospect of treating, and perhaps even eradicating debilitating genetic conditions, improving fertility treatments and ighting cancers. On the other hand, the professor stated, for some people CRISPR also raises the spectre of a bioethical nightmare that opens the door to large-scale bioterrorism or monstrous genetically altered human variants.
The ethical questions of whether we should use this technology, and for what purpose, remain unanswered. ‘I wrote, more than ten years ago, and I still believe, that genetic enhancements are inevitable,’ she said in an interview with European Hospital. ‘Someone among us will do it. I could give the best ethical argument possible why we should not do it, and nevertheless some person will do it. And once that person does it, we all will be off to the races.’ ‘At the end of the day we are speaking about the biggest project imaginable, yet the current discussion of gene editing is not productive. This is because our debate tends to polar extremes either saying this is terrible, we should never do it, or this is great, we should go ahead,’ Baylis said. Before moving on to a discussion of good and bad, Baylis set the table for gene editing where the potential beneits and risks split into two parallel sets. The irst set makes a clinical distinction between the types of cells being manipulated, whether they are somatic cells or germ cells. Simply put, somatic cells are cells in the body of the person being treated and once manipulated the resulting cells stay in the body of that person. Germ cells, on the other hand, are eggs and sperm, and early-stage embryos. The effects on these cells are passed on to any children created by the person who has undergone a treatment. The second great divide in gene editing addresses the clinical intention. Is the manipulation of genes for a therapeutic effect, such as preventing, curing or correcting a disease, or is it for enhancement where human characteristics for everything from muscle mass to eyesight can potentially be manipulated. The ethical issues begin with a question of intention, she said. What are we trying to do? Are we treating? Or are we trying to make better humans? ‘The ield today is divided with respect to which of these categories of activities should be pursued. People are generally supportive of therapeutic interventions in somatic cells, though this is not risk-free. Things could go wrong. This is research, after all. But there is a broad agreement to go ahead,’ she said. ‘People are not in agreement with respect to enhancement, even in somatic cells,’ said Baylis. ‘Yet others are quite enthusiastic and do not see why we would not want to make ourselves a better species. But when we look at germ-line editing, there are people who say this is the Rubicon, it is a line we should not cross; we should never do anything in the germ-line whether for therapy or enhancement. The germ-line is off limits.’ Professor Françoise Baylis is an acknowledged bioethics expert with a special focus on genetic modiication. Her aim is to “move the limits of mainstream bioethics and develop more effective ways to understand and tackle public policy challenges.” She is a member of the Order of Canada and the Order of Nova Scotia, as well as a Fellow of the Royal Society of Canada and a Fellow of the Canadian Academy of Health Sciences. DNA The risk of one person going forward alone into germ-line editing is huge, she said. ‘There are people who wish to be recognised as being the irst, being the brightest. We live in a world that not only fosters but also rewards that kind of competition. ‘And people rightfully worry about the societal effects of this kind of inter- vention. There are concerns about eugenics and discrimination resulting from the fact that some people will have access to these expensive technologies while other people will not. That some could beneit from something not available to others,’ she said. ‘I want us to accept the fact that some kind of gene editing is in our future, and to stop arguing about ‘go’ ‘no-go’. Instead, we should focus on what we can do right now to assure that whatever is done will be done for the beneit of all of us and not just for a minority who are wealthy enough or powerful enough to do this,’ said Baylis. ‘I am interested in how we will negotiate – when we have never done so before – a broad societal consensus of how to use this technology for the beneit of all. We have time to learn. The science is not there, yet,’ Baylis concluded. ‘While scientists are doing that work, why shouldn’t we igure out how to have a meaningful conversation, as one people across the planet, so that it’s actually possible to be humane, and not just human?’ LABBOOK 2017 49
DNA EXTRACTION PerkinElmer – chemagic 360-D Nucleic Acid Extractor Siemens Healthineers – VERSANT kPCR Molecular System Dimensions: Weight: Sample throughput: No of parallel samples: Power supply: 900 × 900 × 820 mm (h × w × d) 140 kg 1 – 96 samples / h 96 1,700 VA Highlights: · DNA isolation directly from human whole blood or plasma samples, no need for additional treatment on primary samples prior to extraction · Sample volumes from 10 μl – 10 ml · Ready to use DNA in high yields and purity · Fast processing times – 96 samples in < 60 min · Long DNA fragments – up to 200 kb suitable for NGS · High recovery rates · Autonomous system regarding downstream assays · For in vitro diagnostic use Dimensions: Channels: Assays: Highlights: 924 ×1,254 × 1,043 mm (h × w × d) Open-channel Real-time PCR assays for infectious disease testing From increased eficiency and new industry standards in extraction to assay reliability and system lexibility, the VERSANT kPCR Molecular System with the MiPLX Software Solution* is a comprehensive molecular diagnostics solution. The open-channel concept and customizable MiPLXsoftware set a new industry standard and further reduce the need for manual labor so that personnel can spend time on other value-added activities. *Product availability varies by country. LIQUID BIOPSY Streck – Cell-Free DNA BCT CE Streck – Cell-Free RNA BCT Dimensions: 16 × 100 mm, 9.0 ml draw Highlights: · Unique direct draw blood collection tube which stabilizes nucleated blood cells · Prevents the release of genomic DNA, allowing isolation of high-quality cell-free DNA and CTCs for clinical research studies, drug discovery and diagnostic assay development · Cell-Free DNA is stable for up to 14 days and CTCs are stable for up to seven days, at room temperature, allowing convenient sample collection, transport and storage · Available in a unique hybrid plastic tube which protects valuable reagent and samples 50 LABBOOK 2017 Dimensions: 16 × 100 mm, 10.0 ml draw Highlights: · Unique direct draw blood collection tube, which stabilizes cell-free RNA in plasma and prevents the release of non-target background RNA from blood cells during sample processing and storage. · Cell-Free RNA is stable for up to seven days, at room temperature, allowing convenient sample collection, transport and storage · Unique hybrid plastic tube to protect valuable reagent and samples
DNA Clostridium dificile Routine diagnostics in the medical laboratory Interview with the physician Dr. Fabian Berger · Institute of Medical Microbiology and Hygiene · Saarland University Medical Center National Advisory Laboratory for Clostridium dificile · Kirrbergerstraße Gebäude 43, 66421 Homburg / Saar As the contact person at the Reference Center for C. dificile, you are consulted every day with the problems of rapid diagnostics and elucidation of outbreaks by this pathogen. What are the advantages of molecular biological procedures compared to conventional C. dificile diagnostics? How does the selected detection method affect the patient? C. dificile diagnostic remains a challenge to this date. Current ESCMID guidelines recommend a screening test such as glutamate dehydrogenase (GDH) or PCR in combination with toxin testing methods e.g. using ELISA or toxigenic culture. Since toxin tests (ELISA) are often false negative due to toxin degradation in the sample and toxigenic culture might take some time rapid diagnostic tools are needed. PCR may serve as a primary tool to exclude toxigenic infection with high sensitivity. Some commercial PCR methods include the detection of strains of higher epidemiological importance such as the classical “hypervirulent” outbreak strain ribotype 027 (RT027) which has become epidemic in some areas showing global spreading. Since other ribotypes are also well known to cause outbreaks (e.g. RT001) the lack of this strain does not elucidate such an event. In these cases culture is needed to collate C. dificile isolates to their speciic ribotype. In cases of an accumulation of one ribotype it is necessary to subtype the strains in order to show potential clonal transmission and the degree of relatedness. Whole Genome Sequencing (WGS) and multiple locus variable number of tandem repeats analysis (MLVA) are suitable tools for further molecular investigation. What do you expect from manufacturers of diagnostic products? Diagnostic tools should cover major virulence factors and if techni- cally possible identify more virulent strains (e.g. RT027 and others). Which role does the Robert Koch Institute (RKI) play, the parent institution of the National Advisory Laboratory? The RKI plays a leading role in establishing measures to prevent C. dificile infection (CDI). In Great Britain for example active measures, such as national control policies, helped to signiicantly reduce CDI incidence. Which strategies are used and developed against hospital infections to reduce the spread of multi-drug resistant pathogens? Due to spore formation C. dificile is a challenge in hygiene. Since disinfectants used for hand and skin hygiene use alcohols that are not able to eliminate spores, hand washing is the only option. For disinfection of surfaces sporocidal disinfectants are needed that are not regularly used in hospitals. Training healthcare personnel in the correct execution of these measures including isolation of CDI patients and personal protective measures, may prove useful. If an outbreak is suspected it is mandatory to type the C. dificile isolates with molecular genetic methods to receive an epidemiological overview and to identify the source of the outbreak. Rapid and effective countermeasures may be able to stop an outbreak in its tracks. We would like to thank Dr. Fabian Berger for the interview and wish him all the best and a lot of success with his responsible work. CONTACT Biomed Labordiagnostik GmbH Dr. Dagmar Michel · Consultant Clinical Diagnostics Bruckmannring 32 · 85764 Oberschleissheim phone: +49 (0)89 315 700 23 · Fax: +49 (0)89 315 700 10 www.biomed.de LABBOOK 2017 51
DNA SERVICE RESEARCH USE ONLY (RUO) Microsynth – Easy-to-Use Cell Line Authentication Service Eppendorf – BioSpectrometer luroescence 18 – 36% of all cell lines are thought to be misidentifi ed or cross-contaminated! Take action and rely on Microsynth’s genotyping experience. Highlights: · Easy: sample preparation and shipment of cell lines at room temperature · Free: daily pickup service via Microsynth collection boxes in Austria, Germany and Switzerland. · Reliable: more than 10 years experience in genotyping · Multiple organisms: Human and Mouse (off-the-shelf) On request we can develop high-quality STR markers for any organisms. · Related services: database comparison of DNA proile (e. g. ATCC), mycoplasma testing, GMP Sanger sequencing · Additional services: NGS, qPCR, contract research Dimensions: Weight: Power consumption: 50 × 295 × 400 mm (h × w × d) 5.4 kg 15 W (during operation), 5 W (dimmed display) Highlights: · Absorbance measurement for one or more wave- lengths, recording of wavelength scans · Sensitive nucleic acid and protein quantiication via luorescence intensity · Integrated application and results memory · Compatible with microliter measuring cells, such as the Eppendorf µCuvette G1.0, and standard cuvettes Eppendorf – Mastercycler nexus X2 Eppendorf – μCuvette G1.0 Dimensions: Weight: No of parallel samples: Temperature range: 321 × 250 × 412 mm (h × w × d) 11 kg 64 / 32 * 0.2ml PCR tubes, up to 64 * 0.5ml PCR tubes 4 – 99°C Dimensions: Height of light beam: Volume: 48 × 12.5 × 12.5 mm (h × w × d) 8.5 mm ≥ 1.5 µL (dsDNA) Highlights: · Microvolume measuring cell for photometric Highlights: · Large block for large assays – small block for small assays · Optional gradient for PCR optimization · E-mail notiication · Flexlid concept allows use of all types of consumables with automatic height adjustment of the lid measurements · Measurement of small sample volumes (1.5 – 10 µL) · Measurement of high sample concentrations without prior dilution · Exclusively available for Eppendorf BioPhotometer and Eppendorf BioSpectrometer 52 LABBOOK 2017
Microbiology MASS SPECTROMETRY Bruker Daltonics – MBT smart Shimadzu – iDplus Assurance Highlights: MBT smart is the MALDI Biotyper High-End option with increased speed, equipped with Bruker’s proprietary smartbeam laser technology. It is the irst MALDI Biotyper system with lifetime laser: seven years warranty or 500 Mio shots (whatever comes irst). The new high-performance vacuum system with increased pump capacity shortens Ready-to-Measure time signiicantly. Available as an IVD solution. Dimensions: Weight: Highlights: 700 × 1,920 × 850 mm (w × h × d) 330 kg, excluding data system Axima Assurance – Flexibility and Quality: The Axima Assurance is designed with the general analytical and life science laboratory in mind. Incorporating a variable repetition rate 50 Hz N2 laser, the system provides high quality and high sensitivity rapid MALDI mass spectra and is particularly suited to identiication in the microbiology ield. Positive and negative ion modes are included as standard, allowing greater lexibility and extending the compound categories that may be analysed. Shimadzu – iDplus Conidence Shimadzu – iDplus Performance Dimensions: Weight: Highlights: 700 × 1,920 × 850 mm (w × h × d) 330 kg, excluding data system iDplus Conidence – Sensitivity and Flexibility: · Rapid microbial identiication for research use · Identiies and classiies strains based on phenotype characteristics · SuperSpectra reduce the incidence of false positives and ensure robustness and reproducibility · Open system allows addition of new species / entries to the database or the creation of new databases · Clustering allows molecular proiling and tracking of change or evolution · High performance MS for large molecule analysis · MS / M Dimensions: Weight: Highlights: 700 × 1,920 × 850 mm (w × h × d) 375 kg, excluding data system iDplus Performance – application-centric solutions: · Rapid microbial identiication for research use · Identiies and classiies strains based on phenotype characteristics · SuperSpectra reduce the incidence of false positives and ensure robustness and reproducibility · Open system allows addition of new species / entries to the database or the creation of new databases · Clustering allows molecular proiling and tracking of change or evolution · High performance MS for large molecule analysis · MS / MS 54 LABBOOK 2017
Shimadzu – MALDI-8020 Olympus – BX46 Ergonomic Upright Microscope MICROSCOPY Microbiology Highlights: · Unrivalled ergonomic design · World’s irst tilting, telescopic, lifting tube · Ultra-low ixed stage Dimensions: Weight: Highlights: 450 × 1,055 × 745 mm (w × h × d) 86 kg The MALDI-8020 is a benchtop, linear-only MALDI-TOF mass spectrometer designed to meet the needs of laboratories requiring a cost-effective MALDI-TOF platform. This newly designed MALDI-TOF mass spectrometer is functionally simple but provides out- standing MS performance in a compact footprint. The BX46 is speciically designed to meet the demands of repetitive routine microscopy. This microscope is focused with a moveable objective nosepiece rather than by moving the stage. The stage is ixed in a very low position, allowing the user to rest their arm on the desk when moving specimens. Ideal user posture is further encouraged by the three-dimensional adjust- ability of the new observation tube, making the BX46 extremely comfortable for continuous daily use. IDENTIFICATION / SUSCEPTIBILITY SAMPLE COLLECTION MetaSystems – Indigo Miacom diagnostics – LIQUILIZER Number of Parallel Samples: Assays: 800 Gram Imaging, Pathogen Identiication by Direct Multiplex Imaging (DMI), Mycobacteria Detection and Quantiication Highlights: MetaSystems Indigo has focused on helping medical decision makers and laboratory professionals rapidly identify pathogens with DMI (Direct Multiplex Imaging), a high-throughput automated analysis system for the identiication and differentiation of clinically relevant microorganisms. The system also scans, digitizes and archives Gram-stained or parasite samples enabling on-screen analysis with remote access. Furthermore, it automatically inds and quantiies mycobacteria such as M. tuberculosis. Assays: CE-Certiied Sputum Liquefaction Reagent Highlights: · miacom‘s Liquillizer allows an immediate liquefaction of respiratory secretions such as sputa · Ready-to-use, DDT free – therefore odourless, no need for preheating or sample prep · No need to prepare fresh on a daily basis – stable at room temperature for up to four weeks after opening reduces validation and documentation work · All standard diagnostic procedures are facilitated LABBOOK 2017 55
Microbiology labbook.eu Trends & innovations in healthcare. For Lab products see here € 19. The Guide to Imaging Technology and Informatics in Europe RAD BOOK 2017 • IT • CT • MRI • Interventional • Mammo • R / F • Nuc • Displays / Printers • Ultrasound • Injectors • Testing Devices Online Portal | Newspaper | Product Guides | Newsletter Your guide to laboratory and pathology equipment in Europe € 15.– More precise diagnostics, low dose and accustomed workflow: Based on dual layer detector technology the IQon Spectral CT from Philips opens up new dimensions in CT imaging. Automation Chemistry & Immunochemistry Hematology Pathology DNA Microbiology POCT IT Non-Diagnostic 2017 · MAGLUMI 4000 Plus, as a new member of MAGLUMI Chemi luminescence Immunoassay (CLIA) analyzers, shares 138 parameters of MAGLUMI reagents which feature stateoftheart illumi nation and separation technologies. Comprehensive test menus help your lab to do more with less and specialty immunoassays. European Hospital Verlags GmbH | Theodor-Althoff-Straße 45 | 45133 Essen 56 LABBOOK 2017 follow us on | visit us on www.healthcare-in-europe.com
POCT Clinical Chemistry Cardiology Coagulation Blood Gases, Electrolytes, Oximetry Infectious Diseases Testing Urinalysis Information Technology Other
POCT CLINICAL CHEMISTRY DiaSys Diagnostic Systems – InnovaStar Orion Diagnostica Oy – QuikRead go Highlights: InnovaStar – POC Testing with superior results in Lab Quality. A high precision system for the determination of HbA1c, CRP, Glucose and Hemoglobine · NGSP / IFCC certiied HbA1c test · Determination of up to four parameters from one 10 µl whole blood sample · Sample individual hematocrit correction to plasma values (CRP, Glucose) · Pre-calibrated test · Fully automated measurements; no manual steps required · User-friendly · Barcoded reagents · Colored touch-screen Dimensions: Weight: Assays: Highlights: 155 × 270 × 145 mm (w × h × d) 1.7 kg CRP, CRP+Hb, Strep A, iFOBT QuikRead go test system brings reliable, easy and fast testing of CRP, CRP+Hb, Strep A and iFOBT in point of care and other near patient settings. QuikRead go tests are CE marked and in use by thousands of healthcare professionals worldwide. QuikRead go CRP is also FDA cleared for use in clinical laboratories. QuikRead go system provides: · laboratory-level results in minutes · ready-to-use test kits · ease of use with fully automatic measurement · connectivity to LIS / HIS CARDIOLOGY COAGULATION Siemens Healthineers – Stratus CS 200 Acute Care System Siemens Healthineers – Xprecia Stride Coagulation Analyze Highlights: The Stratus CS 200 Acute Care Diagnostic System* delivers lab-quality results at the point of care with the speed needed for cardiac patients. Its broad test menu – which includes guideline acceptable troponin I – helps physicians make faster clinical decisions for better patient care. * Not available for sale in the U.S. Product availability varies by country. Highlights: Primary care, urgent care, and hospitals demand fast, reliable PT / INR testing for oral anticoagulation therapy (OAT). That’s why Siemens developed the Xprecia Stride Coagulation Analyzer*, a truly handheld device that tests PT / INR with lab accuracy. With the Xprecia Stride Analyzer, healthcare professionals can feel conident that they are getting the safety, eficiency, and accuracy they need. * Under FDA review. Not available for sale in the U.S. Product availability varies by country. 58 LABBOOK 2017
BLOOD GASES, ELECTROLYTES, OXIMETRY INFECTIOUS DISEASES TESTING Siemens Healthineers – RAPIDPoint 500 Blood Gas System Atlas Genetics – Atlas Genetics io system POCT Dimensions: Weight: Assays: Highlights: 268 × 260 × 384 mm (h × w × d) 10 kg Sexually Transmitted & Hospital Aquired Infections The Atlas Genetics io system is a rapid diagnostic platform designed for use in decentralised laboratories, point-of-care and other near-patient settings, providing a laboratory-accurate test result in 30 minutes. The io system, comprising a small, low cost, easy-to-use instrument and a test-speciic disposable cartridge, delivers a ‘test and treat’ solution for Sexually Transmitted Infections (STI) and Hospital Acquired Infections (HAI), where a rapid, actionable test result, delivered on- demand, can reduce costs and improve patient outcomes. Highlights: The RAPIDPoint 500 Blood Gas System delivers fast, accurate and comprehensive test results for whole blood samples in approximately 60 seconds. It’s lexible, easy to use, and can also perform pleural luid pH testing and measure dialysate luid*. * Not available for sale in the U.S. Product availability varies by country. URINALYSIS Analyticon Biotechnologies – Urilyzer 500 Pro Siemens Healthineers – CLINITEK Novus Urine Analyzer Sample throughput: Assays: Up to 500 tests / h Glucose, Blood, Ketones, Nitrite, Protein, Leucocytes, Bilirubin, Urobilinogen, pH-value, Speciic Gravity, Ascorbic Acid Highlights: · Quality control management with reminder function, lot number and expiration date check · Operator management with multiple authorization levels and operation settings · Touch screen, autostart function, microscopy lag Highlights: (sediment recommendation), continuous loading system · Data management with advanced data entry and lexible, customized testing and reporting options · Memory of 5,000 patient tests and 1,000 QC tests The CLINITEK Novus Automated Urine Chemistry Analyzer combines proven dry-pad urine chemistry technology with an easy-to-use cassette test format to help ensure standardized testing and maximum productivity in busy laboratories. LABBOOK 2017 59
POCT INFORMATION TECHNOLOGY OTHER Siemens Healthineers – RAPIDComm 6.0 Data Management INPECO SA – PROTUBE Highlights: RAPIDComm Data Management System gives you freedom to control your environment and gives you conidence and control over all of the parts of your POC Ecosystem solution. RAPIDComm system enables centralized management of point-of-care testing through a single, customizable interface. It helps streamline worklow, reduce costs, and improve patient care. Dimensions: Weight: Highlights: 275 × 170 × 320 mm (w × h × d) 2.6 kg ProTube is the ideal solution to avoid pre-lab errors, it ensures full traceability of the biological sample collection process. ProTube allows the correct match of right patient with the right tubes, applies the right label and associate the right data for full sample traceability. An intuitive graphical interface guides phlebotomists through the sample collection process. A powerful business intelligence tool for worklow and workload statistics increases the eficiency of the whole process. JADAK – HS-1R Handheld HF RFID Reader SARSTEDT – Minivette POCT / Capillary Blood Collection Dimensions: Weight: Handheld/Stationary: 33.4 x 51.3 x 108.2 mm (h x w x d) 98 grams Handheld 1D & 2D barcode scanner with HF RFID reading & writing functionality Highlights: The lexpoint HS-1R from JADAK integrates 1D & 2D barcode scanning with HF RFID reading & writing functionality. Sure to be an integral part of many medical and clinical applications, the HS-1R enables patient ID via wristband scanning, clinician security login via badge scanning, pharmaceutical applications incl. drug inventory tracking & digital signature capture using built in camera modes, and much more. JADAK products can be tailored to meet speciic customer requirements. 60 LABBOOK 2017 Highlights: · Collection devices for Point-of-Care tests · Easy sample recovery · Precise and dispensing of small whole blood volumes · Prevents spillage during transfer · Volume range: 10µl – 200µl · Preparations: Neutral, Heparin and EDTA
Information Technology LIS, MIDDLEWARE, POCT Beckman Coulter – Command Central Workstation Beckman Coulter – PROService Highlights: Beckman Coulter’s Command Central instrument management system helps manage lab worklow and improve decision-making steps. Connect- ing up to 18 instruments or automation systems, and up to ive networked Command Central workstations within a single laboratory, this increase in lexibility allows the operator to place Command Central workstations in prime locations for optimum laboratory management. Command Central provides lab technicians with a real-time view of laboratory systems from a single point of control to maximize worklow eficiencies. Command Central works with data managers such as REMISOL Advance to achieve worklow eficiencies, or can serve as a stand-alone product for users to monitor automation and / or multiple analyzers and quickly respond to any instrument issues. In addition to serving labs that don’t utilize data management software, Command Central provides an opportunity to apply other Beckman Coulter information systems and worklow solutions all while keeping an eye on what is going on in the lab. Highlights: PROService is Beckman Coulter’s secure remote m anagement and diagnostics system that enables the transfer and analysis of performance data from connected Beckman Coulter systems in the customer laboratory to the customer support staff. This infor- mation is channeled into the PROService system’s suite of features and tools, enabling the service and support teams to review, diagnose and help resolve system issues quickly and eficiently. PROService Remote Management System can help labs maximize uptime, enhance eficiency, and improve productivity. Beckman Coulter – REMISOL Advance i-SOLUTIONS Health – LabCentre Highlights: REMISOL Advance is an enterprise data management solution that can help manage lab worklow, improve the eficiency of labs and standardize operations across multiple sites. It is a unique software product that consolidates patient test information from multiple instruments in the lab or from multiple labs in the hospital network. REMISOL Advance features virtual- ization capability to help reduce failure points, increase uptime, and enhance patient data security. It offers an integrated visual management system to track and trace transported samples from the draw site to the lab enabling your lab to become ISO 15189 compliant. Not available in all geographies. Highlights: LabCentre is a market-leading laboratory and pathology information management system. It helps doctors, scientists, technologists and management staff to track samples and testing processes, communicate results to other health professionals, and monitor costs and reporting. LabCentre supports the following disciplines: · Blood Sciences · Microbiology · Transfusion Medicine · Pathology · Billing 62 LABBOOK 2017
Information Technology Medat – Laboratory Information System Siemens Healthineers – CentraLink Data Management System Highlights: · Flexible, private company with 50 employees. · Complete solution from order entry to billing. · Tailor-made modules for microbiology, virology, environmental hygiene, cytopathology, histopathology and blood banking. · Single, integrated system for all divisions and sites. · Reliable operation in some of Europe’s biggest laboratories. Highlights: CentraLink Data Management System consolidates and standardizes decision making across lab testing, diagnostic systems, automation, and IT to improve accuracy, optimize worklows and streamline operations. Improve patient care with fast, accurate, autovalidated results based on intelligent algorithms and customizable rules that facilitate minimal human intervention. Speed and simplify operations and centralize control of your lab with real-time visibility of sample and result processing metrics. M e h r Q u a l i t ä t i z i e n z i n L a b o r u n d u n d E f P a t h o l o g i e f Auf Erfolg programmiert. Wir bringen Sie im Bereich der Healthcare-IT auf die Gewinnerstraße. Profitieren Sie von unserer erstklassigen Software für den deutschsprachigen Gesundheitsmarkt und von ganzheitlichen Lösungen für Klinik, Labor und Radiologie aus der Hand eines Mittelständlers. agil – intelligent – kundenorientiert – effizient Erfahren Sie mehr auf www.i-solutions.de
Information Technology LIS, MIDDLEWARE, POCT SPECIALTIES Siemens Healthineers – syngo Lab Inventory Manager (sLIM) COMED – RMS /SHS/e-Commerce (B2B) Highlights: sLIM is a real-time inventory-management system that employs cloud-based technology and wireless radio frequency identiication (RFID) to master laboratory inventory management. Incoming inventory is checked into your laboratory’s sLIM website. sLIM automatically detects inventory usage, eliminating manual counting, and recording. Automated order proposals are generated based on your laboratory’s usage. sLIM takes the burden out of managing inventory. *Product availability varies by country. Highlights: · RMS – Reagent Management System is the leading inventory management, supply chain, laboratory controlling and e-commerce solution. · DIMS “Scan & Go” Barcode-Scanner-Solution for laboratories and clinic wards. · Universal & independent B2B-e-commerce for orders, delivery notes and lot control: COMED-customer remains „DATA OWNER” COMED was founded in 1986 and evolved to an interna- tional solution provider for material management and lab controlling. COMEDs‘ unique fusion of IT, consulting and extensive industry know-how and a broad personal network, nowadays serves > 21,000 physicians, > 500 hospitals and > 370 laboratories in 18 countries worldwide with one goal: Enable laboratories, hospitals and rehab clinics to focus on their core business and gain their value-added chain. Zenon – Doc-db QM Suite Zenon – Doc-db Forms & Records Highlights: · Doc-db is a fully featured document management system. The integrated, freely conigurable work- low server makes it easy to adapt to your speciic governance processes. · The creation of documents, read conirmations, reminders, paper copies and many other processes can be comfortably managed, monitored and documented through the system. · Handling of all ile formats enables easy migration of your existing documents into professional document control with Doc-db. · This will ensure that you are it for the requirements needed for the ISO 15189 or ISO 17025 accreditation. Highlights: The new Doc-db module forms and records does all the work. It makes forms that were not previously in the document management system to records that, using the software, can be created, checked, shared, and after manual editing digital archived. · Automated creation of recurring forms and records · Automatic reminder and check for completeness · Direct distribution as a print job to the employees responsible · General and individual design of the worklows for each form / record 64 LABBOOK 2017
Information Technology LabCentre helps scientists, technicians and management staff to track samples and testing processes, communicate results to other health professionals, and monitor costs and reporting. LabCentre – agility and accuracy for all laboratory disciplines Laboratories are an essential part of effective modern healthcare. They provide clinicians with vital information that helps them make life-saving decisions, diagnose conditions and monitor patient treatment. W ith such a critical role in healthcare delivery, laboratory scientists and support staff depend on the very latest technologies to help them carry out their jobs. They need software solutions that work the way they work, that integrate with the devices and technologies they use, and that speed up the analysis they do every day. LabCentre is designed with the needs of those professionals in mind. It is a comprehensive laboratory information management system that helps scientists, technicians and management staff to track samples and testing processes, communicate results to other health professionals, and monitor costs and reporting. Compatible with the most widely used information standards and protocols in the industry, it helps to connect laboratory employees with people throughout the healthcare ecosystem. LabCentre includes dedicated functionality for every laboratory discipline including pathology, and each module of the software has been designed to allow users to create intelligent worklows, helping them to complete laboratory tasks in the most eficient way. One important factor behind this widespread uptake is the lexi bility of the software. Managers can customize the product to function exactly as their organizations require, while individual users can modify speciic functions to suit the processes within a particular laboratory environment. LabCentre has a modular construction so organizations can choose to roll out the product in stages. Many laboratories prefer to deploy one module at a time, ensuring a smooth transition process from legacy systems. All laboratory organizations understand that healthcare tech- nology ultimately has a single purpose: to improve patient care. By increasing the speed and eficiency of laboratories, LabCentre helps institutions to do just that. LABBOOK 2017 65
BLOOD COLLECTION SARSTEDT – S-Monovette – Venous Blood Collection SARSTEDT – Microvette – Capillary Blood Collection Non-Diagnostic Highlights: · S-Monovette – The Revolution in Blood Collection. A blood collection system that combines two blood collection techniques – the aspiration technique and the vacuum technique. · The S-Monovette is suitable for all vein conditions and achieves an optimal sample quality, thereby producing the best results. · The aspiration technique is a gentle technique for routine blood collection. Using the vacuum technique, a “fresh” vacuum is always available. · Suitable for all ages, from young to old, the S-Monovette is as individual as your patients. Highlights: · Flexible capillary blood collection systems such as the Microvette - tailor-made to the individual needs of each patient group. · Different patient groups and collection techniques require different collection systems. · With a nominal volume range from 100 – 500 µl, the capillary blood collection systems product range is one of the most extensive in the entire market. · Depending on the requirements, our portfolio in- cludes Microvettes with conical or round bottom inner tubes and the option for various different collection techniques, end-to-end or with a collection rim. COMPRESSORS SPECIALTIES Dürr Technik – SICOLAB – compressor stations BANDELIN – SONOCOOL – the only ultrasonic bath with cooling Air low: Compressed air quality: up to 145 l / min at 5 bar up to 1:3:1 (according to ISO 8573-1) Highlights: · Oilfree compressed air for many applications · Silent – thanks to excellent soundprooing Highlights: (48 – 54 db [A]) · Compact – its under the laboratory bench · Mobile – with wheels or handling grips · Wide variety of versions · Membrane dryer and ilters as options Using SONOCOOL, the catalytic effect of ultrasound can now be used on heat sensitive samples in analysis laboratories. The cooling function means that exo- thermic reactions can be controlled and the processes are carried out faster and more effectively. The results are available in a shorter time. LABBOOK 2017 67
Non-Diagnostic SPECIALTIES BANDELIN – SONOREX SUPER, SONOREX DIGITEC, SONOPULS BANDELIN – Ultrasonic bath BactoSonic – gentle removing of bioilm Highlights: Ultrasonic baths and homogenisers for: · Cleaning of technical glassware like burettes, pipettes, petri dishes and laboratory lasks · Cleaning and disinfection of medical instruments · Mixing of plasma and sera · Preparation of liposomes in cosmetics and pharmacy · Preparation of samples for analysis of THC-content in canabis or analysis of hair Highlights: The successful treatment of implant infections depends on an accurate microbiological diagnosis. Micro- organisms form bioilms on implant surfaces, what makes them dificult to detect by conventional methods. BactoSonic gently removes bioilms from implant surfaces without killing the bacteria, a quantitative as- sessment is possible. The sonicated liquid is cultured and the quantity of bacteria can be determined. Compared to standard methods up to 10,000 times more bacteria can be detected. ibidi – Cell Culture & Imaging Chambers SARSTEDT – Cell Culture Products Highlights: Choose from the wide variety of ibidi imaging chambers. · Innovative labware solutions for live cell imaging and cell-based assays · Excellent cell culture conditions on the unique ibidi Polymer Coverslip · Supreme optical-grade imaging chambers for high-end microscopy · Available in various open formats or channel slides · Test with a free sample! · Buy four boxes of µ-Slides, µ-Dishes or µ-Plates and receive one additional box for FREE. 68 LABBOOK 2017 Highlights: For over 20 years Sarstedt has produced a wide range of high quality cell culture products which are distributed worldwide. These many years of experience and know- ledge of the needs of users have allowed us to optimise and continually expand the product range.
n o i t a m o t u A ■ g n i s s e c o r P e l p m a S ■ 4 A u t o m a t e d S a m p l e P r o c e s s i n g m e h c o n u m m I / y r t s i y r t s i m e h C ■ Companies / Suppliers y r t e m o r t c e p S s s a M ■ l y g o o t a m e H ■ l y g o o h t a P ■ A N D ■ 47 i l y g o o b o r c i M ■ l y g o o n h c e T n o i t a m r o f n ■ I T C O P ■ 59 59 i c i t s o n g a D - n o N ■ 67 68 8 4 12 16 17 25 28 32 12 33 46 46 24 21 37 54 62 64 12 13 58 13 28 17 LABBOOK 2017 69 Page Index Agena Bioscience GmbH Mendelssohnstraße 15D 22761 Hamburg, Germany phone: +49 40 899676-0 support-europe@AgenaBio.com www.agenabio.com Analyticon Biotechnologies AG Am Mühlenberg 10 35104 Lichtenfels, Germany phone: +49 6454 7991-0 · fax: +49 6454 7991-30 info@analyticon-diagnostics.com www.analyticon-diagnostics.com ASP Lab Automation AG Rugenranzel 4 25373 Ellerhoop, Germany phone: +49 4120 70679-27 info@asplabauto.com www.asplabauto.com Atlas Genetics Ltd White Horse Business Park, Derby Court, Epsom Square Trowbridge BA14 OXG, UK phone: +44 (0) 1225 71930 info@atlasgenetics.com www.atlasgenetics.com BANDELIN electronic GmbH & Co. KG Heinrichstraße 3-4 12207 Berlin, Germany phone: +49 30 76880-0 info@bandelin.com www.bandelin.com Beckman Coulter, Inc. 250 S. Kramer Boulevard Brea, CA 92822, USA phone: +1 714 9935321 cvillarreal@beckman.com www.beckmancoulter.com Biomed Labordiagnostik GmbH Bruckmannring 32 85764 Oberschleißheim, Germany phone: +49 89 315700-0 info@biomed.de www.biomed.de BIORON Diagnostics GmbH Rheinhorststraße 18 67071 Ludwigshafen, Germany phone: +49 621 545900-70 info@bioron.de www.bioron.de biostep GmbH Innere Gewerbestraße 7 09235 Burkhardtsdorf, Germany phone: +49 3721 3905-0 info@biostep.de www.biostep.de · www.biostep.org Bruker Daltonik GmbH Fahrenheitstraße 4 28359 Bremen, Germany phone: +49 421 2205-0 · fax: +49 421 2205-305 ms.sales.bdal@bruker.com www.bruker.com COMED Computerorganisation in der Medizin GmbH Köttersweg 11 59494 Soest, Germany phone: +49 2921 9630-0 comed@comed-com.de www.comed-com.de DiaSys Diagnostic Systems GmbH Alte Straße 9 65558 Holzheim, Germany phone: +49 6432 9146-0 info@diasys.de www.diasys-diagnostics.com Diatron MI Zrt. Táblás u. 39 1097 Budapest, Hungary phone: +36 1 436 9800 marketing@diatron.com www.diatron.com DRG Instruments GmbH Frauenbergstraße 18 35039 Marburg, Germany phone: +49 6421 1700-0 raeder@drg-diagnostics.de www.drg-diagnostics.de
g n i s s e c o r P e l p m a S ■ n o i t a m o t u A ■ 8 Companies / Suppliers Page Index Dürr Technik GmbH & Co. KG Pleidelsheimer Straße 30 74321 Bietigheim-Bissingen, Germany phone: +49 7142 9022-0 · fax: +49 7142 9022-99 ofice@duerr-technik.de www.duerr-technik.com Eppendorf AG Barkhausenweg 1 22339 Hamburg, Germany phone: +49 40 53801-0 · fax: +49 40 53801-556 eppendorf@eppendorf.de www.eppendorf.de Fujirebio Europe NV Technologiepark 6 B-9052 Gent, Belgium phone: +32 9 329 1329 www.fujirebio-europe.com Genrui Biotech Inc. 6F, Shanshui Building B, Nanshan Yungu Innovation Industrial Park, 1183 Liuxian Blvd, Nanshan District, 518055, Shenzhen, China phone: +86 755 26 83 55 60-1 (-2) international@genrui-bio.com · www.genrui-bio.com Hamamatsu Photonics Deutschland GmbH Arzbergerstraße 10 82211 Herrsching, Germany phone: +49 8152 375-203 dialog@hamamatsu.de www.nanozoomer.com HORIBA Medical Parc Euromédecine 34184 Montpellier, France phone: +33 467 141516 webmaster.med@horiba.com www.horiba.com/medical ibidi GmbH Am Klopferspitz 19 82152 Martinsried, Germany phone: +49 89 5204617-0 info@ibidi.de www.ibidi.com INPECO SA Via San Gottardo 10 6900 Lugano, Switzerland phone: +41 91 9118200 marketing@inpeco.com www.inpeco.com i-SOLUTIONS Health GmbH Am Exerzierplatz 14 68167 Mannheim, Germany phone: +49 621 3928-0 · fax: +49 621 3928-527 info@i-solutions.de www.i-solutions.de JADAK Europe Emmastraat 16 4811 AG Breda, The Netherlands phone: +31 76 522 5588 info@jadak.eu www.jadak.eu KUGEL medical GmbH & Co. KG Hermann-Köhl-Straße 2 A 93049 Regensburg, Germany phone: +49 941 208648-0 info@kugel-medical.de www.kugel-medical.de Medat Computersysteme GmbH Albrechtstraße 14 80636 München, Germany phone: +49 89 126808-0 info@medat.de www.medat.de MEDITE GmbH Wollenweberstraße 12 31303 Burgdorf, Germany phone: +49 5136 8884-0 sales@medite.de www.medite-group.com MetaSystems Hard & Software GmbH Robert-Bosch-Straße 6 68804 Altlussheim, Germany phone +49 6205 39610 info@metasystems-international.com www.metasystems-indigo.com 70 LABBOOK 2017 i c i t s o n g a D - n o N ■ 67 68 T C O P ■ 60 60 l y g o o n h c e T n o i t a m r o f n ■ I 62 63 m e h c o n u m m I / y r t s i y r t s i m e h C ■ l i y g o o b o r c i M ■ y r t e m o r t c e p S s s a M ■ l y g o o t a m e H ■ l y g o o h t a P ■ A N D ■ 52 17 14 28 37 38 42 28 39 33 39 55
m e h c o n u m m I / y r t s i y r t s i m e h C ■ g n i s s e c o r P e l p m a S ■ n o i t a m o t u A ■ Companies / Suppliers l y g o o n h c e T n o i t a m r o f n ■ I i c i t s o n g a D - n o N ■ T C O P ■ y r t e m o r t c e p S s s a M ■ l y g o o t a m e H ■ l y g o o h t a P ■ A N D ■ 52 l i y g o o b o r c i M ■ 55 9 14 18 30 38 55 46 58 50 39 4 5 18 46 60 67 68 9 5 9 21 21 24 26 15 18 20 24 25 19 20 15 26 54 55 30 33 34 50 58 59 60 63 64 32 50 31 32 34 LABBOOK 2017 71 Page Index miacom diagnostics GmbH Merowingerplatz 1a 40225 Düsseldorf, Germany phone: +49 211 30155795 info@miacom-diagnostics.com www.miacom-diagnostics.com Microsynth Schützenstraße 7 9436 Balgach, Switzerland phone: +41 71 722 8333 info@microsynth.ch www.microsynth.ch SHENZHEN MINDRAY Bio-Medical Electronics Co., LTD. Mindray Building, Keji 12th Road South, Nanshan 518057 Shenzhen, China phone: +86 755 81 888 998 intl-market@mindray.com · www.mindray.com Olympus Europa SE & Co KG Wendenstraße 14 -18 20097 Hamburg, Germany phone: +49 40 23773-0 ScientiicSolutions@olympus-europa.com www.olympus-lifescience.com Orion Diagnostica Oy Koivu-Mankkaantie 6 B 02200 Espoo, Finland phone: +358 10 4261 orion.diagnostica@oriondiagnostica.i www.oriondiagnostica.com PerkinElmer chemagen Technologie GmbH Arnold-Sommerfeld-Ring 2 52499 Baesweiler, Germany phone: +49 2401 805500 support.chemagen@perkinelmer.com www.chemagen.com Primera Technology Europe Mainzer Str. 131 65187 Wiesbaden, Germany phone: +49 611 92777-0 sales@primera.eu www.primera-healthcare.eu SARSTEDT AG & Co. Sarstedtstraße 1 51588 Nümbrecht, Germany phone: +49 2293 305-0 / fax: +49 2293 305-122 info@sarstedt.com www.sarstedt.com SCIEX Diagnostics 500 Old Connecticut Path Framingham, MA 01701, USA phone: +1 508 383 7700 www.sciexdiagnostics.com/contact-us www.sciexdiagnostics.com SHIMADZU Europa GmbH Albert Hahn Straße 6-10 47269 Duisburg, Germany phone: +49 203 7687-0 shimadzu@shimadzu.eu www.shimadzu.eu Siemens Healthineers Laboaratory Diagnostics 511 Benedict Avenue 10591 Tarrytown, NY, USA phone: +1 914 631 8000 www.healthcare.siemens.com Shenzhen New Industries Biomedical Engineering Co., Ltd. 21st Floor, Block A, Building 1, Shenzhen Software Industry Base, No. 1008, Keyuan Road, Nanshan District 518000 Shenzhen, China phone: +86 755 26501514 sales@snibe.com · www.snibe.com Streck 7002 S 109th St 68128 Omaha, USA phone: +1 402 333 1982 international@streck.com www.streck.com Sysmex Europe GmbH Bornbarch 1 22848 Norderstedt, Germany phone: +49 40 527-260 info@sysmex-europe.com www.sysmex-europe.com
m e h c o n u m m I / y r t s i y r t s i m e h C ■ l y g o o n h c e T n o i t a m r o f n ■ I i c i t s o n g a D - n o N ■ T C O P ■ l i y g o o b o r c i M ■ y r t e m o r t c e p S s s a M ■ l y g o o t a m e H ■ 34 35 A N D ■ l y g o o h t a P ■ 42 20 64 g n i s s e c o r P e l p m a S ■ n o i t a m o t u A ■ Companies / Suppliers Page Index TECO Medical Instruments Dieselstraße 1 84088 Neufahrn, Germany phone: +49 8773 70780-0 info@teco-gmbh.com www.teco-medical.com Visiopharm A/S Agern Allé 24 2970 Hørsholm, Denmark phone: +45 88 202088 marketing@visiopharm.com www.visiopharm.com Wako Chemicals GmbH Fuggerstraße 12 41468 Neuss, Germany phone: +49 2131 311-163 kueper@wako-chemicals.de www.wako-chemicals.de Zenon GmbH Hüttenstraße 3 44795 Bochum, Germany phone: +49 234 9430535 · fax: +49 234 9430536 info@zenon-net.de www.docdb.de Notes 72 LABBOOK 2017
The Reference Institute for Bioanalytics External quality control at the highest level www.rfb.bio OUR MISSION is the performance of proiciency tests in accordance with the guidelines of the German Medical Association for quality assurance of laboratory medical investigation KEY FACTS • RfB is accredited in accordance with DIN ISO 17043 and DIN ISO 17025 • Proiciency tests for all parts of the RiliBÄK (B1-B5) • Developement of more than 30 reference methods • 30 years experience with EQAs • More than 110.000 participations in 2014 • Customers from 76 countries Reference Institute for Bioanalytics (RfB) - Friesdorfer Str. 153 - 53175 Bonn - Germany - Phone: +49 228 92 68 95 0 - info@rfb-dgkl.de
Unique solution to overcome the bottleneck in sample preparation Whole in one CLAM-2000* – the world’s first fully automated sample preparation module for LC-MS The new CLAM-2000 is the world’s first system able to perform all steps fully automated from pretreatment of the sample to LC-MS analysis. The CLAM-2000 provides a “whole in one solu- tion” in the areas of clinical, pharmaceutical and pathological research, biological and immuno- logical analysis, or medical laboratories. Dramatically improved workflow with better safety and higher reproducibility for clinical research Large choice to adapt to sensitivity needs through compatibility with the LCMS-8040, -8045, -8050 and -8060 systems Uniform pretreatment times between samples improving analysis accuracy Integrated and easy to use online sample pretreatment and LC-MS controlled by a GUI on a touch panel www.shimadzu.eu/clam-2000 *For Research Use Only. Not for use in diagnostic procedures. Not available in the USA, Canada and China.