Chimeric antigen receptor (CAR) T-cell therapy is an immunotherapy treatment that re-engineers a patient’s own T-cells to help them attack malignant tumour cells. It has been very effective in the treatment of blood cancers, including certain types of leukaemia and lymphoma. However, two serious side effects are common as a result of the treatment: cytokine release syndrome (CRS) and immune…
Women suffering from multiple sclerosis temporarily get much better when pregnant. Researchers have now identified the beneficial changes naturally occurring during pregnancy.
French scientists discovered that CD4 T cells generated during immunotherapy are capable of remotely neutralizing tumor cells by producing interferon gamma (IFN-γ).
Researchers at Karolinska Institutet have found further evidence for how the Epstein-Barr virus (EBV) can trigger multiple sclerosis (MS) or drive disease progression.
A new class of immunotherapy shows promising results for fighting the most aggressive form of skin cancer.
New research has found molecular signature differences in the blood of patients who fully recover from Covid-19 and those who develop long Covid.
Multiple sclerosis affects three women for every one man. French scientists are studying the role of the sex hormones in order to better understand this discrepancy.
For pancreatic cancer, the effect of immunotherapy is limited and differs between men and women. Researchers at Karolinska Institutet have now found a possible explanation for this sex difference.
Dutch physicians have developed a system to determine the right dose of immunosuppressive drugs for patients to receive a donor liver - to prevent the activation of the Epstein-Barr virus.
Dutch scientists have discovered how specialized immune cells can detect and remove cancers that are ‘invisible’ to the conventional defense mechanisms of the immune system.
After an infection with SARS-CoV-2, some people fail to recover their sense of smell. US researchers took a closer look at the olfactory nerve cells to find the reason for Covid-19-induced anosmia.
A new study has found that antibodies produced in the nose decline nine months after Covid-19 infection, while antibodies found in the blood last at least a year.
Dutch scientists have performed whole-body PET scans using a radioactively labeled antibody tracer against immune cells, to predict the effect of treatment with immune checkpoint inhibitors.
The diminished power of the immune system in older adults is usually blamed on the aging process. But a new study shows that decades of particulate air pollution also take a toll.
Blood stem cell transplantation is a radical but highly effective therapy for multiple sclerosis. A study examined how the treatment curbs the disease and how the immune system regenerates afterwards.
Researchers from Barcelona report that vaccination with senescent cells shows promise in experimental models of melanoma and pancreatic cancer.
A vaccine design approach that could protect against new variants of SARS-CoV-2 but also potentially protects against other coronaviruses is one step closer to reality as a result of new research.
A study in Japan finds antibody response to the Moderna Covid-19 mRNA vaccine does not vary depending on the time of day when the dose was received.
Researchers mapped in detail how the immune system acts against pathogens invading the brain. This sheds new light on host-pathogen interactions and the long-term consequences of brain infections.
Researchers have shown that when brain cells are directly exposed to blood taken from Covid-19 patients with delirium, there is an increase in cell death and a decrease in the generation of new brain cells.
A large epidemiological study shows that patients with an autoimmune disorder have a substantially higher risk of developing cardiovascular disease than individuals without autoimmune disease.
Researchers propose a new Covid-19 vaccine that specifically instructs the immune system to produce T-cells rather than antibodies - a promising alternative for people with a weakened immune system.
Cancer immunotherapy is a successful treatment form in oncology, but it doesn't work for every patient. One problem may be the lack of a specific type of immune cell in the tumor, researchers found.
By comparing the neutralisation capacity induced by the different variants of SARS-CoV-2, a team from Geneva reveals the exceptional capacity of Omicron to evade our immunity.
To develop new drugs, detailed knowledge about nature’s smallest biological building blocks is required. A new microscopy technique that allows proteins, DNA and other tiny biological particles to be studied in their natural state.